ENZYME entry: EC 3.4.23.42

Accepted Name
Thermopsin.
Reaction catalysed
Specificity similar to pepsin A, prefers bulky hydrophobic side-chains on either side of the scissible bond
Comment(s)
  • Isolated from cells and culture medium of the thermophilic archae Sulfolobus acidocaldarius, optimum digestion at pH 2 and 90 degrees Celsius, inhibited by pepstatin.
  • Another thermostable bacterial endopeptidase has been isolated from Bacillus sp., but this is not inhibited by pepstatin.
  • Belongs to peptidase family A5.
  • Formerly EC 3.4.99.43.
Cross-references
BRENDA3.4.23.42
EC2PDB3.4.23.42
ExplorEnz3.4.23.42
PRIAM enzyme-specific profiles3.4.23.42
KEGG Ligand Database for Enzyme Nomenclature3.4.23.42
IUBMB Enzyme Nomenclature3.4.23.42
IntEnz3.4.23.42
MEDLINEFind literature relating to 3.4.23.42
MetaCyc3.4.23.42
UniProtKB/Swiss-Prot
P17118, THPS_SULAC

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