ENZYME entry: EC 3.4.24.11

Accepted Name
Neprilysin.
Alternative Name(s)
Endopeptidase-2.
Enkephalinase.
Kidney-brush-border neutral proteinase.
Membrane metalloendopeptidase.
Neutral endopeptidase.
Reaction catalysed
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
Cofactor(s)
Zn(2+).
Comment(s)
  • A membrane-bound glycoprotein widely distributed in animal tissues.
  • Inhibited by phosphoramidon and thiorphan.
  • Belongs to peptidase family M13.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.11
EC2PDB3.4.24.11
ExplorEnz3.4.24.11
PRIAM enzyme-specific profiles3.4.24.11
KEGG Ligand Database for Enzyme Nomenclature3.4.24.11
IUBMB Enzyme Nomenclature3.4.24.11
IntEnz3.4.24.11
MEDLINEFind literature relating to 3.4.24.11
MetaCyc3.4.24.11
UniProtKB/Swiss-Prot
Q495T6, MMEL1_HUMAN;  Q9JLI3, MMEL1_MOUSE;  P0C1T0, MMEL1_RAT;  
P08473, NEP_HUMAN;  Q61391, NEP_MOUSE;  P19621, NEP_PIG;  
Q5RE69, NEP_PONAB;  P08049, NEP_RABIT;  P07861, NEP_RAT;  

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