ENZYME entry: EC 3.4.24.11

Accepted Name
Neprilysin.
Alternative Name(s)
Endopeptidase-2.
Enkephalinase.
Kidney-brush-border neutral proteinase.
Membrane metalloendopeptidase.
Neutral endopeptidase.
Reaction catalysed
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
Cofactor(s)
Zinc.
Comment(s)
A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Belongs to peptidase family M13.
Cross-references
PROSITE	PDOC00129
BRENDA	3.4.24.11
EC2PDB	3.4.24.11
ExplorEnz	3.4.24.11
PRIAM enzyme-specific profiles	3.4.24.11
KEGG Ligand Database for Enzyme Nomenclature	3.4.24.11
IUBMB Enzyme Nomenclature	3.4.24.11
IntEnz	3.4.24.11
MEDLINE	Find literature relating to 3.4.24.11
MetaCyc	3.4.24.11
UniProtKB/Swiss-Prot	Q495T6, MMEL1_HUMAN;   Q9JLI3, MMEL1_MOUSE;   P0C1T0, MMEL1_RAT;   P08473, NEP_HUMAN;   Q61391, NEP_MOUSE;   P19621, NEP_PIG;   Q5RE69, NEP_PONAB;   P08049, NEP_RABIT;   P07861, NEP_RAT;

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