ENZYME entry: EC 3.4.24.13
| Accepted Name |
|---|
| IgA-specific metalloendopeptidase.
|
| Alternative Name(s) |
|---|
| IgA protease. |
| Immunoglobulin A1 proteinase. |
| Reaction catalysed |
|---|
| Cleavage of Pro-|-Thr bond in the hinge region of the heavy chain of human IgA |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Found in several pathogenic species of Streptococcus such as
S.sanguis and S.pneumoniae.
- There is also an IgA-specific prolyl endopeptidase of serine-type
(see EC 3.4.21.72).
- Belongs to peptidase family M26.
|
| Cross-references |
|---|
| BRENDA | 3.4.24.13 |
| EC2PDB | 3.4.24.13 |
| ExplorEnz | 3.4.24.13 |
| PRIAM enzyme-specific profiles | 3.4.24.13 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.13 |
| IUBMB Enzyme Nomenclature | 3.4.24.13 |
| IntEnz | 3.4.24.13 |
| MEDLINE | Find literature relating to 3.4.24.13 |
| MetaCyc | 3.4.24.13 |
| UniProtKB/Swiss-Prot |
|
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