ENZYME entry: EC 3.4.24.18
| Accepted Name |
|---|
| Meprin A.
|
| Alternative Name(s) |
|---|
| Endopeptidase-2. |
| Reaction catalysed |
|---|
| Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- A membrane-bound metalloendopeptidase of rat and mouse kidney and
intestinal brush borders, and salivary ducts.
- Differences from EC 3.4.24.11 include insensitivity to phosphoramidon
and thiorphan.
- PABA-peptide hydrolase is a very similar enzyme found in human
intestinal microvilli.
- Belongs to peptidase family M12A.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.18 |
| EC2PDB | 3.4.24.18 |
| ExplorEnz | 3.4.24.18 |
| PRIAM enzyme-specific profiles | 3.4.24.18 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.18 |
| IUBMB Enzyme Nomenclature | 3.4.24.18 |
| IntEnz | 3.4.24.18 |
| MEDLINE | Find literature relating to 3.4.24.18 |
| MetaCyc | 3.4.24.18 |
| UniProtKB/Swiss-Prot |
|
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