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ENZYME

ENZYME entry: EC 3.4.25.1

Accepted Name
proteasome endopeptidase complex
Alternative Name(s)
ingensin
Lens neutral proteinase
macropain
multicatalytic endopeptidase complex
multicatalytic proteinase (complex)
prosome
proteasome
Reaction catalysed
Cleavage of peptide bonds with very broad specificity
Comment(s)
  • A 20-S protein composed of 28 subunits arranged in four rings of seven.
  • The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity.
  • In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities.
  • The molecule is barrel-shaped, and the active sites are on the inner surfaces.
  • Terminal apertures restrict access of substrates to the active sites.
  • Inhibited by mercurial reagents and some inhibitors of serine endopeptidases.
  • Belongs to peptidase family T1.
  • Formerly EC 3.4.22.21, EC 3.4.24.5 and EC 3.4.99.46.
Cross-references
BRENDA3.4.25.1
EC2PDB3.4.25.1
ExplorEnz3.4.25.1
PRIAM enzyme-specific profiles3.4.25.1
KEGG Ligand Database for Enzyme Nomenclature3.4.25.1
IUBMB Enzyme Nomenclature3.4.25.1
IntEnz3.4.25.1
MEDLINEFind literature relating to 3.4.25.1
MetaCyc3.4.25.1
Rhea expert-curated reactions3.4.25.1
UniProtKB/Swiss-Prot
Q5B7I7, INPE_EMENIA7KE01, PB6LA_SALSAA7KII6, PB6LB_SALSA
Q9XUV0, PBS5_CAEELQ3T0T1, PSB10_BOVINP40306, PSB10_HUMAN
O35955, PSB10_MOUSEQ4KM35, PSB10_RATA5LHX3, PSB11_HUMAN
Q8BG41, PSB11_MOUSEQ9YES4, PSB1_AERPEA8MBW0, PSB1_CALMQ
A0RU86, PSB1_CENSYB8D673, PSB1_DESA1Q8SR11, PSB1_ENCCU
Q5V4S6, PSB1_HALMAD2RQX3, PSB1_HALTVA2BN24, PSB1_HYPBU
A8AA46, PSB1_IGNH4B1L6S7, PSB1_KORCOA4YIE0, PSB1_METS5
A9A4A1, PSB1_NITMSQ9V247, PSB1_PYRABQ8ZYF2, PSB1_PYRAE
A4WH05, PSB1_PYRARA3MS44, PSB1_PYRCJQ8U4C9, PSB1_PYRFU
O57983, PSB1_PYRHOA1RSJ8, PSB1_PYRILB1YA36, PSB1_PYRNV
Q53079, PSB1_RHOERQ980L4, PSB1_SACS2D0KRX1, PSB1_SACS9
A4X3P0, PSB1_SALTOO43063, PSB1_SCHPOA3DN21, PSB1_STAMF
Q82JE3, PSB1_STRAWQ4JAY3, PSB1_SULACC3N5N4, PSB1_SULIA
D2PK63, PSB1_SULIDC4KHB0, PSB1_SULIKC3MQ16, PSB1_SULIL
C3MVD5, PSB1_SULIMC3NFX2, PSB1_SULINC3NE98, PSB1_SULIY
Q975U8, PSB1_SULTOD1A2S9, PSB1_THECDC5A7L1, PSB1_THEGJ
Q5JDJ9, PSB1_THEKOB6YSW2, PSB1_THEONA1RWY6, PSB1_THEPD
C6A2V9, PSB1_THESMP38624, PSB1_YEASTQ9YER0, PSB2_AERPE
A8M8R5, PSB2_CALMQA0RXV1, PSB2_CENSYB8D683, PSB2_DESA1
Q8SQN7, PSB2_ENCCUQ5V1D5, PSB2_HALMAD2RUI0, PSB2_HALTV
A2BN27, PSB2_HYPBUA8AB58, PSB2_IGNH4B1L6X8, PSB2_KORCO
A4YJ04, PSB2_METS5A9A2U7, PSB2_NITMSQ9V0N9, PSB2_PYRAB
Q8ZST5, PSB2_PYRAEA4WMZ0, PSB2_PYRARA3MXQ6, PSB2_PYRCJ
Q8U125, PSB2_PYRFUO50110, PSB2_PYRHOA1RTI7, PSB2_PYRIL
B1YDJ0, PSB2_PYRNVQ53083, PSB2_RHOERQ9UXF3, PSB2_SACS2
D0KTH0, PSB2_SACS9A4X744, PSB2_SALTOQ09841, PSB2_SCHPO
A3DN27, PSB2_STAMFQ828I8, PSB2_STRAWQ4JAA8, PSB2_SULAC
C3MZI0, PSB2_SULIAD2PDG6, PSB2_SULIDC4KIR0, PSB2_SULIK
C3MRE5, PSB2_SULILC3MY41, PSB2_SULIMC3NHF1, PSB2_SULIN
C3N7K2, PSB2_SULIYQ975D1, PSB2_SULTOD1A3V2, PSB2_THECD
C5A2D5, PSB2_THEGJQ5JHL8, PSB2_THEKOB6YXV3, PSB2_THEON
A1RX71, PSB2_THEPDC6A3R1, PSB2_THESMP25043, PSB2_YEAST
O23717, PSB5A_ARATHQ9LIP2, PSB5B_ARATHQ32KL2, PSB5_BOVIN
P34065, PSB5_CHICKQ54BC8, PSB5_DICDIP28074, PSB5_HUMAN
O55234, PSB5_MOUSEQ5R8S2, PSB5_PONABP28075, PSB5_RAT
P30655, PSB5_SCHPOO24361, PSB5_SPIOLP30656, PSB5_YEAST
Q8LD27, PSB6_ARATHQ3MHN0, PSB6_BOVINQ55GJ6, PSB6_DICDI
P28072, PSB6_HUMANQ60692, PSB6_MOUSEP28073, PSB6_RAT
P93395, PSB6_TOBACO23710, PSB7A_ARATHQ7DLS1, PSB7B_ARATH
Q2TBP0, PSB7_BOVINQ54QR2, PSB7_DICDIQ99436, PSB7_HUMAN
P70195, PSB7_MOUSEA1XQU1, PSB7_PIGQ9JHW0, PSB7_RAT
Q3T112, PSB8_BOVINQ5W416, PSB8_CANLFP28062, PSB8_HUMAN
P28063, PSB8_MOUSEQ29576, PSB8_PIGP28064, PSB8_RAT
Q3SZC2, PSB9_BOVINP28065, PSB9_HUMANP28076, PSB9_MOUSE
O35522, PSB9_MUSMBO35523, PSB9_MUSPLO35524, PSB9_MUSSI
O35521, PSB9_MUSTRQ9PT26, PSB9_ONCMYQ8UW64, PSB9_ORYLA
P28077, PSB9_RATQ9DD33, PSB9_SALSAB5IEE5, PSB_ACIB4
A0LU50, PSB_ACIC1C7LYP7, PSB_ACIFDC6WID8, PSB_ACTMD
Q9P996, PSB_ARCFUD2RGT4, PSB_ARCPAA0JWY6, PSB_ARTS2
C5BVA2, PSB_BEUC1C7PVV2, PSB_CATADD3RX66, PSB_FERPA
Q0RLT7, PSB_FRAAAQ2J9Q3, PSB_FRACCA8LH54, PSB_FRASN
D2S6E2, PSB_GEOOGD0LDT1, PSB_GORB4B9LTS6, PSB_HALLT
C7NVQ4, PSB_HALMDB0R4C8, PSB_HALS3Q9HR36, PSB_HALSA
C7NQ99, PSB_HALUDD4GYZ1, PSB_HALVDQ18GX3, PSB_HALWD
C7R403, PSB_JONDDA6W970, PSB_KINRDD2Q4H4, PSB_KRIFD
A6UT20, PSB_META3Q8TJB5, PSB_METACQ0W2D6, PSB_METAR
A7I841, PSB_METB6Q46G14, PSB_METBFQ12YV7, PSB_METBU
C7P6N4, PSB_METFAQ2FQL8, PSB_METHJQ58634, PSB_METJA
Q8TW10, PSB_METKAA2SS78, PSB_METLZA4FYA5, PSB_METM5
A9A788, PSB_METM6A6VK02, PSB_METM7Q8PZ04, PSB_METMA
A3CUS9, PSB_METMJQ6LZD4, PSB_METMPD5EAS6, PSB_METMS
B8GG66, PSB_METPED1Z199, PSB_METPSD3E0A3, PSB_METRM
A5UM14, PSB_METS3D3S8M7, PSB_METSFQ2NI68, PSB_METST
Q9P992, PSB_METTEO27270, PSB_METTHA0B5B1, PSB_METTP
C9REN7, PSB_METVMA6USJ3, PSB_METVSA0QFB5, PSB_MYCA1
B1MAI2, PSB_MYCA9Q7TZ13, PSB_MYCBOA1KKF3, PSB_MYCBP
C1AQ26, PSB_MYCBTA4TB64, PSB_MYCGIB8ZRF3, PSB_MYCLB
Q49780, PSB_MYCLEB2HFV6, PSB_MYCMMQ73YW8, PSB_MYCPA
A0QZ47, PSB_MYCS2A3Q193, PSB_MYCSJA1UHS7, PSB_MYCSK
Q1B797, PSB_MYCSSA5U4D6, PSB_MYCTAA5WP84, PSB_MYCTF
C6DPV1, PSB_MYCTKP9WHT8, PSB_MYCTOP9WHT9, PSB_MYCTU
A0PQT3, PSB_MYCUAA1TAP4, PSB_MYCVPC8XAQ4, PSB_NAKMY
Q74MP5, PSB_NANEQD3SSQ6, PSB_NATMMQ3IPX1, PSB_NATPD
Q5YUX2, PSB_NOCFAA1SK13, PSB_NOCSJA1R6Q7, PSB_PAEAT
Q6L181, PSB_PICTOB8H8L6, PSB_PSECPA9WSI1, PSB_RENSM
C0ZZU7, PSB_RHOE4Q0SIF9, PSB_RHOJRC1ASP7, PSB_RHOOB
A4FBY1, PSB_SACENC7MWV7, PSB_SACVDA8M2A3, PSB_SALAI
D1BHT9, PSB_SANKSD3Q557, PSB_STANLQ7AKQ5, PSB_STRCO
B1W306, PSB_STRGGD2ATV1, PSB_STRRDC9Z4D0, PSB_STRSW
P28061, PSB_THEACQ47NZ4, PSB_THEFYQ97AZ7, PSB_THEVO
D1BS26, PSB_XYLCX

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.25.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-