ENZYME entry: EC 3.5.1.122

Accepted Name
Protein N-terminal glutamine amidohydrolase.
Reaction catalysed
N-terminal L-glutaminyl-[protein] + H(2)O <=> N-terminal L-glutamyl-[protein] + NH(3)
Comment(s)
  • This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln.
  • Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to L-glutamate.
  • The latter serves as a substrate for EC 2.3.2.8 making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
Cross-references
BRENDA3.5.1.122
EC2PDB3.5.1.122
ExplorEnz3.5.1.122
PRIAM enzyme-specific profiles3.5.1.122
KEGG Ligand Database for Enzyme Nomenclature3.5.1.122
IUBMB Enzyme Nomenclature3.5.1.122
IntEnz3.5.1.122
MEDLINEFind literature relating to 3.5.1.122
MetaCyc3.5.1.122
UniProtKB/Swiss-Prot
Q7Q968, NTAQ1_ANOGA;  O22944, NTAQ1_ARATH;  Q3T0D3, NTAQ1_BOVIN;  
A8Y183, NTAQ1_CAEBR;  Q21775, NTAQ1_CAEEL;  Q1LWX3, NTAQ1_DANRE;  
B3MCF3, NTAQ1_DROAN;  B3NQ86, NTAQ1_DROER;  B4J8A0, NTAQ1_DROGR;  
Q7K2Y9, NTAQ1_DROME;  B4KPY6, NTAQ1_DROMO;  Q28WL0, NTAQ1_DROPS;  
B4HSF8, NTAQ1_DROSE;  B4QGZ1, NTAQ1_DROSI;  B4MDT2, NTAQ1_DROVI;  
B4MQL4, NTAQ1_DROWI;  B4P6V4, NTAQ1_DROYA;  Q96HA8, NTAQ1_HUMAN;  
Q80WB5, NTAQ1_MOUSE;  B8AXU2, NTAQ1_ORYSI;  Q60E61, NTAQ1_ORYSJ;  
Q5BJV9, NTAQ1_RAT;  Q5PPU8, NTAQ1_XENLA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-