ENZYME entry: EC 3.5.1.124

Accepted Name
Protein deglycase.
Alternative Name(s)
Glyoxylase III.
Reaction catalysed
  • An N(omega)-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H(2)O <=> a [protein]-L-arginine + (R)-lactate
  • An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O <=> a [protein]-L-lysine + (R)-lactate
  • An S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H(2)O <=> a [protein]-L-cysteine + (R)-lactate
Comment(s)
  • The enzyme, previously thought to be a glyoxalase, acts on glycated L-arginine, L-lysine, and L-cysteine residues within proteins that have been attacked and modified by glyoxal or 2-oxopropanal.
  • The attack forms hemithioacetal in the case of cysteines and aminocarbinols in the case of arginines and lysines.
  • The enzyme repairs the amino acids, releasing glycolate or (R)- lactate, depending on whether the attacking agent was glyoxal or 2-oxopropanal, respectively.
Cross-references
BRENDA3.5.1.124
EC2PDB3.5.1.124
ExplorEnz3.5.1.124
PRIAM enzyme-specific profiles3.5.1.124
KEGG Ligand Database for Enzyme Nomenclature3.5.1.124
IUBMB Enzyme Nomenclature3.5.1.124
IntEnz3.5.1.124
MEDLINEFind literature relating to 3.5.1.124
MetaCyc3.5.1.124
UniProtKB/Swiss-Prot
A7ZN88, HCHA_ECO24;  B7MCM0, HCHA_ECO45;  B7L8Y4, HCHA_ECO55;  
Q8XB78, HCHA_ECO57;  B5YSJ3, HCHA_ECO5E;  B7NRB5, HCHA_ECO7I;  
B7MWF3, HCHA_ECO81;  B7M3A5, HCHA_ECO8A;  C4ZQN7, HCHA_ECOBW;  
B1X6B7, HCHA_ECODH;  A8A1G6, HCHA_ECOHS;  A1ACB2, HCHA_ECOK1;  
Q0TGM8, HCHA_ECOL5;  P59331, HCHA_ECOL6;  B1IZU5, HCHA_ECOLC;  
P31658, HCHA_ECOLI;  B7NBV8, HCHA_ECOLU;  B6I112, HCHA_ECOSE;  
B1LQP2, HCHA_ECOSM;  Q1RAH5, HCHA_ECOUT;  B7UX51, HCHA_PSEA8;  
Q02IV5, HCHA_PSEAB;  Q9I4K0, HCHA_PSEAE;  B2TWL8, HCHA_SHIB3;  
Q0T3G3, HCHA_SHIF8;  P59332, HCHA_SHIFL;  Q3Z0M5, HCHA_SHISS;  
A7WYY0, HCHA_STAA1;  A6TZ28, HCHA_STAA2;  Q2FJ89, HCHA_STAA3;  
Q2G0M7, HCHA_STAA8;  A5IQA5, HCHA_STAA9;  Q2YSB0, HCHA_STAAB;  
Q5HIC4, HCHA_STAAC;  A6QEK3, HCHA_STAAE;  P64312, HCHA_STAAM;  
P64313, HCHA_STAAN;  Q6GJB7, HCHA_STAAR;  Q6GBT6, HCHA_STAAS;  
A8YZP8, HCHA_STAAT;  Q8NXY2, HCHA_STAAW;  Q5E946, PARK7_BOVIN;  
Q8UW59, PARK7_CHICK;  Q95LI9, PARK7_CHLAE;  Q5XJ36, PARK7_DANRE;  
Q99497, PARK7_HUMAN;  Q7TQ35, PARK7_MESAU;  Q99LX0, PARK7_MOUSE;  
O88767, PARK7_RAT;  Q46948, YAJL_ECOLI;  P55880, YAJL_SALTY;  
P45470, YHBO_ECOLI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
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