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ENZYME entry: EC 3.5.1.14

Accepted Name
N-acyl-aliphatic-L-amino acid amidohydrolase.
Alternative Name(s)
Acylase I.
Aminoacylase 1.
Aminoacylase I.
Benzamidase.
Dehydropeptidase II.
Hippuricase.
Histozyme.
N-acyl-L-amino-acid amidohydrolase.
Reaction catalysed
  • An N-acyl-aliphatic-L-amino acid + H(2)O <=> an aliphatic L-amino acid + a carboxylate
  • An N-acetyl-L-cysteine-S-conjugate + H(2)O <=> an L-cysteine-S-conjugate + acetate
Cofactor(s)
Zn(2+).
Comment(s)
  • The enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
  • It acts on mercapturic acids (S-conjugates of N-acetyl-L-cysteine) and neutral aliphatic N-acyl-alpha-amino acids.
  • Some bacterial aminoacylases demonstrate substrate specificity of both EC 3.5.1.14 and EC 3.5.1.114.
  • Cf. EC 3.5.1.15 and EC 3.5.1.114.
Cross-references
PROSITEPDOC00613
BRENDA3.5.1.14
EC2PDB3.5.1.14
ExplorEnz3.5.1.14
PRIAM enzyme-specific profiles3.5.1.14
KEGG Ligand Database for Enzyme Nomenclature3.5.1.14
IUBMB Enzyme Nomenclature3.5.1.14
IntEnz3.5.1.14
MEDLINEFind literature relating to 3.5.1.14
MetaCyc3.5.1.14
UniProtKB/Swiss-Prot
K9NBS6, AAM_RHOER;  Q6AYS7, ACY1A_RAT;  Q6PTT0, ACY1B_RAT;  
Q55DP8, ACY1_DICDI;  Q03154, ACY1_HUMAN;  Q99JW2, ACY1_MOUSE;  
P37111, ACY1_PIG;  Q5RFB0, ACY1_PONAB;  P37112, AMAA_GEOSE;  
P37356, AMAA_GEOTM;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-