ENZYME

ENZYME entry: EC 3.5.1.77

Accepted Name

N-carbamoyl-D-amino-acid hydrolase.

Alternative Name(s)

D-N-carbamoylase.

N-carbamoyl-D-amino acid hydrolase.

N-carbamoylase.

Reaction catalysed

N-carbamoyl-D-amino acid + H(2)O <=> D-amino acid + NH(3) + CO(2)

Comment(s)

This enzyme, along with EC 3.5.1.87, EC 5.1.99.5 and EC 3.5.2.2, forms part of the reaction cascade known as the 'hydantoinase process', which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids.
Has strict stereospecificity for N-carbamoyl-D-amino acids and does not act upon the corresponding L-amino acids or N-formyl amino acids, N-carbamoyl-sarcosine, -citrulline, -allantoin and -ureidopropanoate, which are substrates for other amidohydrolases.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature