ENZYME entry: EC 3.5.4.16

Accepted Name
GTP cyclohydrolase I.
Reaction catalysed
GTP + H(2)O <=> formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Comment(s)
  • The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic.
  • Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.
Cross-references
PROSITEPDOC00672
BRENDA3.5.4.16
EC2PDB3.5.4.16
ExplorEnz3.5.4.16
PRIAM enzyme-specific profiles3.5.4.16
KEGG Ligand Database for Enzyme Nomenclature3.5.4.16
IUBMB Enzyme Nomenclature3.5.4.16
IntEnz3.5.4.16
MEDLINEFind literature relating to 3.5.4.16
MetaCyc3.5.4.16
UniProtKB/Swiss-Prot
Q9CGE3, FOLKE_LACLA;  Q8GJP4, FOLKE_LACLM;  Q8YLL1, GCH11_NOSS1;  
Q9HYG8, GCH11_PSEAE;  Q88LV4, GCH11_PSEPK;  Q887V1, GCH11_PSESM;  
Q8YN49, GCH12_NOSS1;  Q9I351, GCH12_PSEAE;  Q88JY1, GCH12_PSEPK;  
Q884Q3, GCH12_PSESM;  A3N0R3, GCH1_ACTP2;  B3GXP9, GCH1_ACTP7;  
B0BPI8, GCH1_ACTPJ;  A0KIN6, GCH1_AERHH;  A4SPE8, GCH1_AERS4;  
Q8UEK8, GCH1_AGRT5;  B9JWF1, GCH1_AGRVS;  B6EGN8, GCH1_ALISL;  
Q0A939, GCH1_ALKEH;  O66603, GCH1_AQUAE;  A8HUG2, GCH1_AZOC5;  
C1DHG2, GCH1_AZOVD;  A7Z630, GCH1_BACA2;  C3P598, GCH1_BACAA;  
C3L8S8, GCH1_BACAC;  A0RBW5, GCH1_BACAH;  Q81SW2, GCH1_BACAN;  
B7JGZ6, GCH1_BACC0;  Q73AY4, GCH1_BACC1;  B7IP89, GCH1_BACC2;  
C1EN08, GCH1_BACC3;  B7HHR5, GCH1_BACC4;  B7HL21, GCH1_BACC7;  
A7GN48, GCH1_BACCN;  B9IVN3, GCH1_BACCQ;  Q81FQ8, GCH1_BACCR;  
Q63DM1, GCH1_BACCZ;  Q5L925, GCH1_BACFN;  Q64P85, GCH1_BACFR;  
Q9KCC7, GCH1_BACHD;  Q6HL44, GCH1_BACHK;  A8FEL2, GCH1_BACP2;  
P48063, GCH1_BACPU;  P19465, GCH1_BACSU;  Q8A0U0, GCH1_BACTN;  
A9VMC0, GCH1_BACWK;  A1USJ5, GCH1_BARBK;  Q6G3J8, GCH1_BARHE;  
Q6FZZ4, GCH1_BARQU;  Q1LT77, GCH1_BAUCH;  B2IBC4, GCH1_BEII9;  
B3DR12, GCH1_BIFLD;  Q8G3S1, GCH1_BIFLO;  Q7VRX3, GCH1_BLOFL;  
Q492J7, GCH1_BLOPB;  Q89IW2, GCH1_BRADU;  C0ZCC7, GCH1_BREBN;  
B2S5T0, GCH1_BRUA1;  Q2YQ03, GCH1_BRUA2;  Q57D61, GCH1_BRUAB;  
A9M586, GCH1_BRUC2;  C0RJ47, GCH1_BRUMB;  Q8YH94, GCH1_BRUME;  
A5VQL0, GCH1_BRUO2;  B0CGM4, GCH1_BRUSI;  Q8G0L4, GCH1_BRUSU;  
Q8KA05, GCH1_BUCAP;  Q19980, GCH1_CAEEL;  A8MC60, GCH1_CALMQ;  
A7ZB36, GCH1_CAMC1;  A7GW42, GCH1_CAMC5;  A8FJZ5, GCH1_CAMJ8;  
A7H1R1, GCH1_CAMJD;  P51594, GCH1_CAMJE;  A1VXS2, GCH1_CAMJJ;  
Q5HWX4, GCH1_CAMJR;  B9KDZ8, GCH1_CAMLR;  Q3ADI2, GCH1_CARHZ;  
Q9AAY3, GCH1_CAUCR;  P50141, GCH1_CHICK;  Q3ATN0, GCH1_CHLCH;  
Q8KEA8, GCH1_CHLTE;  Q1QV64, GCH1_CHRSD;  Q7NYZ2, GCH1_CHRVO;  
A8AE79, GCH1_CITK8;  Q97D54, GCH1_CLOAB;  A7FU67, GCH1_CLOB1;  
C3KVW3, GCH1_CLOB6;  A6LWG6, GCH1_CLOB8;  A5I231, GCH1_CLOBH;  
C1FN26, GCH1_CLOBJ;  B1IL94, GCH1_CLOBK;  A7GDP1, GCH1_CLOBL;  
B1L1S1, GCH1_CLOBM;  B8I184, GCH1_CLOCE;  Q18BW7, GCH1_CLOD6;  
B9E092, GCH1_CLOK1;  A5N6S3, GCH1_CLOK5;  A0Q2L7, GCH1_CLONN;  
Q0TRM0, GCH1_CLOP1;  Q8XLM2, GCH1_CLOPE;  Q0STY9, GCH1_CLOPS;  
A3DHH6, GCH1_CLOTH;  C3PJE8, GCH1_CORA7;  Q8FMG3, GCH1_COREF;  
A4QH94, GCH1_CORGB;  Q8NM84, GCH1_CORGL;  A9KFF3, GCH1_COXBN;  
A9NDB3, GCH1_COXBR;  Q83DE3, GCH1_COXBU;  Q3Z782, GCH1_DEHE1;  
A5FQD3, GCH1_DEHSB;  Q3ZYB5, GCH1_DEHSC;  Q9RYB4, GCH1_DEIRA;  
A4J5D0, GCH1_DESRM;  Q94465, GCH1_DICDI;  P48596, GCH1_DROME;  
A7ZNX6, GCH1_ECO24;  B7UFG9, GCH1_ECO27;  B7MF66, GCH1_ECO45;  
B7LAH4, GCH1_ECO55;  P0A6T7, GCH1_ECO57;  B5YWU3, GCH1_ECO5E;  
B7NMB8, GCH1_ECO7I;  B7MXG6, GCH1_ECO81;  B7M4Z9, GCH1_ECO8A;  
C4ZU03, GCH1_ECOBW;  B1X7P1, GCH1_ECODH;  A8A214, GCH1_ECOHS;  
A1AD13, GCH1_ECOK1;  Q0TFT7, GCH1_ECOL5;  P0A6T6, GCH1_ECOL6;  
B1IYB6, GCH1_ECOLC;  P0A6T5, GCH1_ECOLI;  B7NCI3, GCH1_ECOLU;  
B6I8K3, GCH1_ECOSE;  B1LKQ0, GCH1_ECOSM;  Q1R9R9, GCH1_ECOUT;  
C5BCL9, GCH1_EDWI9;  A4WCI8, GCH1_ENT38;  Q82Z12, GCH1_ENTFA;  
B2VII2, GCH1_ERWT9;  B7LVB3, GCH1_ESCF3;  P51597, GCH1_EUGGR;  
B0S1R1, GCH1_FINM2;  A5FHM7, GCH1_FLAJ1;  Q8RH43, GCH1_FUSNN;  
Q5KXT7, GCH1_GEOKA;  C5D3E8, GCH1_GEOSW;  Q7NK98, GCH1_GLOVI;  
Q7VM90, GCH1_HAEDU;  Q4QKH4, GCH1_HAEI8;  A5UC59, GCH1_HAEIE;  
A5UEW4, GCH1_HAEIG;  P43866, GCH1_HAEIN;  Q2SPJ2, GCH1_HAHCH;  
C4K3L4, GCH1_HAMD5;  Q17WX5, GCH1_HELAH;  Q7VFG4, GCH1_HELHP;  
B6JME9, GCH1_HELP2;  B5Z7T2, GCH1_HELPG;  Q1CSU6, GCH1_HELPH;  
Q9ZKS2, GCH1_HELPJ;  B2UU76, GCH1_HELPS;  P56462, GCH1_HELPY;  
Q0I3F6, GCH1_HISS1;  B0UUA9, GCH1_HISS2;  P30793, GCH1_HUMAN;  
B4U640, GCH1_HYDS0;  A2BL58, GCH1_HYPBU;  Q0BXB5, GCH1_HYPNA;  
A6SZ52, GCH1_JANMA;  B5XP57, GCH1_KLEP3;  A6TBN8, GCH1_KLEP7;  
Q88ST4, GCH1_LACPL;  Q38WN0, GCH1_LACSS;  Q6ACQ1, GCH1_LEIXX;  
B0S8X8, GCH1_LEPBA;  Q04P36, GCH1_LEPBJ;  Q056J8, GCH1_LEPBL;  
B0SRX6, GCH1_LEPBP;  Q72LY8, GCH1_LEPIC;  Q8EYG1, GCH1_LEPIN;  
Q92A75, GCH1_LISIN;  C1KWN3, GCH1_LISMC;  Q71Y82, GCH1_LISMF;  
B8DBZ3, GCH1_LISMH;  Q8Y5X1, GCH1_LISMO;  A0AK45, GCH1_LISW6;  
B1HTA3, GCH1_LYSSC;  Q65TR0, GCH1_MANSM;  Q0AM02, GCH1_MARMM;  
Q11JM4, GCH1_MESSB;  Q607T5, GCH1_METCA;  B0U881, GCH1_METS4;  
Q05915, GCH1_MOUSE;  P51598, GCH1_MUCPU;  A0QA85, GCH1_MYCA1;  
B1MGU9, GCH1_MYCA9;  P64208, GCH1_MYCBO;  A1KPU4, GCH1_MYCBP;  
C1AI67, GCH1_MYCBT;  A4T5P2, GCH1_MYCGI;  B8ZU42, GCH1_MYCLB;  
O69531, GCH1_MYCLE;  B2HJ53, GCH1_MYCMM;  Q743Z2, GCH1_MYCPA;  
A5U8T4, GCH1_MYCTA;  P9WN56, GCH1_MYCTO;  P9WN57, GCH1_MYCTU;  
A0PV57, GCH1_MYCUA;  A1TG42, GCH1_MYCVP;  P51599, GCH1_NEUCR;  
Q2Y6B3, GCH1_NITMU;  B2J1L7, GCH1_NOSP7;  A6X0X0, GCH1_OCHA4;  
P51596, GCH1_ONCMY;  O61573, GCH1_OSTOS;  A6LFE8, GCH1_PARD8;  
P57865, GCH1_PASMU;  Q6D3N3, GCH1_PECAS;  C6DEM6, GCH1_PECCP;  
A5D2D8, GCH1_PELTS;  Q4FL89, GCH1_PELUB;  C0QPU5, GCH1_PERMH;  
Q7N6K7, GCH1_PHOLL;  Q6LQL4, GCH1_PHOPR;  P51600, GCH1_PHYBL;  
B2RIJ1, GCH1_PORG3;  Q7MWI5, GCH1_PORGI;  A4SF37, GCH1_PROVI;  
Q15YG1, GCH1_PSEA6;  Q3IF89, GCH1_PSEHT;  Q8ZWW5, GCH1_PYRAE;  
B1YCT7, GCH1_PYRNV;  Q8XZK8, GCH1_RALSO;  P22288, GCH1_RAT;  
Q98LQ6, GCH1_RHILO;  Q92QB4, GCH1_RHIME;  C3MB45, GCH1_RHISN;  
Q7UJJ7, GCH1_RHOBA;  Q2IY20, GCH1_RHOP2;  Q6N4E7, GCH1_RHOPA;  
Q212N0, GCH1_RHOPB;  Q134L7, GCH1_RHOPS;  B3QE25, GCH1_RHOPT;  
C3PNA0, GCH1_RICAE;  A8GN89, GCH1_RICAH;  A8GUB6, GCH1_RICB8;  
Q1RID0, GCH1_RICBR;  Q92I93, GCH1_RICCN;  Q4ULX3, GCH1_RICFE;  
A8F1F2, GCH1_RICM5;  Q9ZDE8, GCH1_RICPR;  C4K2D8, GCH1_RICPU;  
B0BXB8, GCH1_RICRO;  A8GRW0, GCH1_RICRS;  Q68WZ4, GCH1_RICTY;  
B5EYP3, GCH1_SALA4;  A9MK63, GCH1_SALAR;  Q57ME6, GCH1_SALCH;  
B5FNJ7, GCH1_SALDC;  B5R163, GCH1_SALEP;  B5RC32, GCH1_SALG2;  
B4TAL5, GCH1_SALHS;  B4SY26, GCH1_SALNS;  Q5PE52, GCH1_SALPA;  
A9N6K0, GCH1_SALPB;  C0Q0U7, GCH1_SALPC;  B5BE43, GCH1_SALPK;  
B4TNQ0, GCH1_SALSV;  P64210, GCH1_SALTI;  P64209, GCH1_SALTY;  
O13774, GCH1_SCHPO;  A8GC24, GCH1_SERP5;  A1S2C7, GCH1_SHEAM;  
B8E4J0, GCH1_SHEB2;  A3CZJ1, GCH1_SHEB5;  A6WIA1, GCH1_SHEB8;  
A9KXZ9, GCH1_SHEB9;  Q12SG0, GCH1_SHEDO;  A3QIQ4, GCH1_SHELP;  
Q8E9L6, GCH1_SHEON;  A4Y2K7, GCH1_SHEPC;  A0L1S4, GCH1_SHESA;  
Q0HE51, GCH1_SHESM;  Q0HZU8, GCH1_SHESR;  A1REU0, GCH1_SHESW;  
B2TVT9, GCH1_SHIB3;  Q31YW1, GCH1_SHIBS;  Q32EN8, GCH1_SHIDS;  
Q0T2X1, GCH1_SHIF8;  P0A6T8, GCH1_SHIFL;  Q3Z053, GCH1_SHISS;  
A6U8C2, GCH1_SINMW;  Q2NUE3, GCH1_SODGM;  Q3K0Y1, GCH1_STRA1;  
Q8E549, GCH1_STRA3;  Q8DZI5, GCH1_STRA5;  Q82EE8, GCH1_STRAW;  
Q9X8I3, GCH1_STRCO;  A8AZD8, GCH1_STRGC;  B1VSG4, GCH1_STRGG;  
Q8DUG2, GCH1_STRMU;  P0C0C2, GCH1_STRP1;  Q04MF9, GCH1_STRP2;  
P0DB30, GCH1_STRP3;  B5E6W5, GCH1_STRP4;  Q5XCA9, GCH1_STRP6;  
C1CB65, GCH1_STRP7;  P0A3E9, GCH1_STRP8;  A2REL9, GCH1_STRPG;  
B1I918, GCH1_STRPI;  B8ZL26, GCH1_STRPJ;  P51595, GCH1_STRPN;  
P0DB31, GCH1_STRPQ;  B2ISL9, GCH1_STRPS;  P0C0C1, GCH1_STRPY;  
B5XLE8, GCH1_STRPZ;  P59656, GCH1_STRR6;  A4W1S9, GCH1_STRS2;  
A3CKF4, GCH1_STRSV;  A4VVH1, GCH1_STRSY;  Q5LYM8, GCH1_STRT1;  
Q5M391, GCH1_STRT2;  C1CC81, GCH1_STRZJ;  C1CIH2, GCH1_STRZP;  
C1CPG4, GCH1_STRZT;  Q4J8S2, GCH1_SULAC;  C3MZ97, GCH1_SULIA;  
C4KIH5, GCH1_SULIK;  C3MR62, GCH1_SULIL;  C3MXF1, GCH1_SULIM;  
C3NGB7, GCH1_SULIN;  C3N7B7, GCH1_SULIY;  Q980E8, GCH1_SULSO;  
B2V9P4, GCH1_SULSY;  Q971G9, GCH1_SULTO;  Q54769, GCH1_SYNE7;  
Q2JR69, GCH1_SYNJA;  Q2JPT8, GCH1_SYNJB;  Q5N623, GCH1_SYNP6;  
Q55759, GCH1_SYNY3;  C5BL73, GCH1_TERTT;  Q8DJB8, GCH1_THEEB;  
Q47KU5, GCH1_THEFY;  B0KCE5, GCH1_THEP3;  B0K5C1, GCH1_THEPX;  
Q8R7N2, GCH1_THETN;  B5YJV0, GCH1_THEYD;  C4LDE6, GCH1_TOLAT;  
A7N6L2, GCH1_VIBCB;  Q9KLX5, GCH1_VIBCH;  Q5E4E4, GCH1_VIBF1;  
B5FF36, GCH1_VIBFM;  Q87GZ6, GCH1_VIBPA;  Q8D6I7, GCH1_VIBVU;  
Q7MDE5, GCH1_VIBVY;  Q8D2N7, GCH1_WIGBR;  Q7M933, GCH1_WOLSU;  
Q8PEP3, GCH1_XANAC;  Q3BM80, GCH1_XANC5;  Q8P3B0, GCH1_XANCP;  
B2I4L2, GCH1_XYLF2;  Q9PC02, GCH1_XYLFA;  B0U794, GCH1_XYLFM;  
Q87D63, GCH1_XYLFT;  P51601, GCH1_YEAST;  A1JU09, GCH1_YERE8;  
A7FJL1, GCH1_YERP3;  B2JZ02, GCH1_YERPB;  Q8ZG15, GCH1_YERPE;  
A9R1B1, GCH1_YERPG;  B1JQJ4, GCH1_YERPY;  Q1BR24, GCH41_BURCA;  
B1K3S8, GCH41_BURCC;  A0AYZ1, GCH41_BURCH;  Q39AS8, GCH41_BURS3;  
Q47IT5, GCH41_DECAR;  Q1LPE1, GCH41_RALME;  Q1BLY8, GCH42_BURCA;  
B1K5N3, GCH42_BURCC;  A0B338, GCH42_BURCH;  Q393P5, GCH42_BURS3;  
Q47BI9, GCH42_DECAR;  Q1LK35, GCH42_RALME;  Q6FBI2, GCH4_ACIAD;  
B2ULP4, GCH4_AKKM8;  Q0VMK6, GCH4_ALCBS;  Q0AA39, GCH4_ALKEH;  
Q5P229, GCH4_AROAE;  A1K4Q9, GCH4_AZOSB;  C1DM03, GCH4_AZOVD;  
Q9KE60, GCH4_BACHD;  Q65ML7, GCH4_BACLD;  P94398, GCH4_BACSU;  
Q6MKE9, GCH4_BDEBA;  Q2KZ16, GCH4_BORA1;  Q7WL36, GCH4_BORBR;  
Q7W7P9, GCH4_BORPA;  A9ITA7, GCH4_BORPD;  Q7VV88, GCH4_BORPE;  
B1Z1G3, GCH4_BURA4;  Q0BAL7, GCH4_BURCM;  A9ANA1, GCH4_BURM1;  
A3MBD3, GCH4_BURM7;  A2S0N7, GCH4_BURM9;  Q62DU0, GCH4_BURMA;  
A1UYQ5, GCH4_BURMS;  A3P7W3, GCH4_BURP0;  Q3JKA4, GCH4_BURP1;  
A3NMF5, GCH4_BURP6;  B2JP67, GCH4_BURP8;  Q63JF5, GCH4_BURPS;  
Q2T7N4, GCH4_BURTA;  A4JLT5, GCH4_BURVG;  Q13RX0, GCH4_BURXL;  
B9MNP4, GCH4_CALBD;  A4XG24, GCH4_CALS8;  Q1R153, GCH4_CHRSD;  
A8AF20, GCH4_CITK8;  Q47VM6, GCH4_COLP3;  B5Y6R9, GCH4_COPPD;  
Q0K861, GCH4_CUPNH;  Q474C1, GCH4_CUPPJ;  A9C020, GCH4_DELAS;  
C6C0U6, GCH4_DESAD;  B8J1Q5, GCH4_DESDA;  Q30X45, GCH4_DESDG;  
A8ZUJ6, GCH4_DESOH;  Q6AMT5, GCH4_DESPS;  Q727G3, GCH4_DESVH;  
B8DLK8, GCH4_DESVM;  A1VAN0, GCH4_DESVV;  A5EXB0, GCH4_DICNV;  
B5YCT4, GCH4_DICT6;  B8DZH0, GCH4_DICTD;  A8LS52, GCH4_DINSH;  
B1YHT1, GCH4_EXIS2;  C4KZ55, GCH4_EXISA;  A7HKP2, GCH4_FERNB;  
B5EDQ6, GCH4_GEOBB;  Q39R36, GCH4_GEOMG;  Q74FW8, GCH4_GEOSL;  
C6E7E6, GCH4_GEOSM;  A5G8S1, GCH4_GEOUR;  Q2SLC0, GCH4_HAHCH;  
A1WYI8, GCH4_HALHL;  A4G1X0, GCH4_HERAR;  Q5R041, GCH4_IDILO;  
A6SUS5, GCH4_JANMA;  Q28R88, GCH4_JANSC;  Q6U5S4, GCH4_KLEPN;  
C5CEC0, GCH4_KOSOT;  Q1MPD2, GCH4_LAWIP;  B9E8N6, GCH4_MACCJ;  
A0L8I1, GCH4_MAGSM;  Q605G6, GCH4_METCA;  Q1GZD6, GCH4_METFK;  
A2SJ45, GCH4_METPP;  Q5F9K6, GCH4_NEIG1;  A9M3N5, GCH4_NEIM0;  
Q9JV35, GCH4_NEIMA;  Q9K023, GCH4_NEIMB;  A1KT61, GCH4_NEIMF;  
Q0AFY5, GCH4_NITEC;  Q82VD1, GCH4_NITEU;  Q2YCH6, GCH4_NITMU;  
Q3J9J7, GCH4_NITOC;  Q8EQK9, GCH4_OCEIH;  B1ZTR5, GCH4_OPITP;  
A1BA17, GCH4_PARDP;  Q3A091, GCH4_PELCD;  A1AU47, GCH4_PELPD;  
A4SZK2, GCH4_POLSQ;  Q48HN1, GCH4_PSE14;  Q15Z55, GCH4_PSEA6;  
A6VF17, GCH4_PSEA7;  B7V776, GCH4_PSEA8;  Q02DG9, GCH4_PSEAB;  
Q9HT35, GCH4_PSEAE;  Q1I2L2, GCH4_PSEE4;  Q4K3E8, GCH4_PSEF5;  
C3K4H5, GCH4_PSEFS;  Q3ILJ5, GCH4_PSEHT;  A4Y119, GCH4_PSEMY;  
A5W348, GCH4_PSEP1;  Q3K4B0, GCH4_PSEPF;  B0KR89, GCH4_PSEPG;  
Q88HM9, GCH4_PSEPK;  B1JFN3, GCH4_PSEPW;  Q882P7, GCH4_PSESM;  
Q4ZU60, GCH4_PSEU2;  A1STF0, GCH4_PSYIN;  Q8XX96, GCH4_RALSO;  
A3PH01, GCH4_RHOS1;  Q3J5D3, GCH4_RHOS4;  A4WQ81, GCH4_RHOS5;  
B9KM22, GCH4_RHOSK;  Q168P4, GCH4_ROSDO;  Q5LTR1, GCH4_RUEPO;  
Q1GF96, GCH4_RUEST;  A1AVX5, GCH4_RUTMC;  A8GF39, GCH4_SERP5;  
A7WZ02, GCH4_STAA1;  A6TZ43, GCH4_STAA2;  Q2FJ74, GCH4_STAA3;  
Q2G0L1, GCH4_STAA8;  A5IQC0, GCH4_STAA9;  Q2YS98, GCH4_STAAB;  
Q5HIA9, GCH4_STAAC;  A6QEL9, GCH4_STAAE;  Q99W43, GCH4_STAAM;  
Q7A777, GCH4_STAAN;  Q6GJA3, GCH4_STAAR;  Q6GBS1, GCH4_STAAS;  
A8YZR4, GCH4_STAAT;  Q8NXX2, GCH4_STAAW;  B9DKT0, GCH4_STACT;  
Q5HRI1, GCH4_STAEQ;  Q8CTR6, GCH4_STAES;  Q4L3P5, GCH4_STAHJ;  
Q49VB3, GCH4_STAS1;  Q2LUP0, GCH4_SYNAS;  A0LQR3, GCH4_SYNFM;  
B7ICT4, GCH4_THEAB;  A8F7Q8, GCH4_THELT;  A6LKE7, GCH4_THEM4;  
Q9WXP6, GCH4_THEMA;  B9K795, GCH4_THENN;  A5IL29, GCH4_THEP1;  
B1LAA9, GCH4_THESQ;  Q31EF8, GCH4_THICR;  Q3SKF2, GCH4_THIDA;  
A5CXA1, GCH4_VESOH;  Q8PLL4, GCH4_XANAC;  Q3BUL9, GCH4_XANC5;  
Q4UTV2, GCH4_XANC8;  B0RTU4, GCH4_XANCB;  Q8P9T3, GCH4_XANCP;  
Q2P374, GCH4_XANOM;  B2SJL4, GCH4_XANOP;  Q5H0A0, GCH4_XANOR;  
B2IAI3, GCH4_XYLF2;  Q9PBP4, GCH4_XYLFA;  B0U741, GCH4_XYLFM;  
Q87DA5, GCH4_XYLFT;  P45371, GTPC1_ALLVD;  O28497, GTPC1_ARCFU;  
Q9KD39, GTPC1_BACHD;  P54472, GTPC1_BACSU;  O51424, GTPC1_BORBU;  
Q05B89, GTPC1_BOVIN;  P57387, GTPC1_BUCAI;  Q8K9N4, GTPC1_BUCAP;  
Q89AJ8, GTPC1_BUCBP;  Q9PPK2, GTPC1_CAMJE;  Q9PKS8, GTPC1_CHLMU;  
Q9Z946, GTPC1_CHLPN;  O84110, GTPC1_CHLTR;  Q97JI0, GTPC1_CLOAB;  
Q8XIV9, GTPC1_CLOPE;  Q9RY41, GTPC1_DEIRA;  Q55E83, GTPC1_DICDI;  
Q9NK57, GTPC1_DROME;  P0AFP8, GTPC1_ECO57;  P0AFP7, GTPC1_ECOL6;  
P0AFP6, GTPC1_ECOLI;  Q57354, GTPC1_HAEIN;  Q9HP80, GTPC1_HALSA;  
Q9ZKP2, GTPC1_HELPJ;  O25613, GTPC1_HELPY;  Q9GZT8, GTPC1_HUMAN;  
Q9CGM3, GTPC1_LACLA;  Q92BQ8, GTPC1_LISIN;  P53434, GTPC1_LISMO;  
Q58337, GTPC1_METJA;  O27214, GTPC1_METTH;  Q9EQ80, GTPC1_MOUSE;  
P0A657, GTPC1_MYCBO;  O69481, GTPC1_MYCLE;  Q98QB0, GTPC1_MYCPU;  
P9WFM0, GTPC1_MYCTO;  P9WFM1, GTPC1_MYCTU;  Q9JWG6, GTPC1_NEIMA;  
Q9JXG9, GTPC1_NEIMB;  Q8YS75, GTPC1_NOSS1;  Q9CP72, GTPC1_PASMU;  
Q9HVX2, GTPC1_PSEAE;  Q9UYT3, GTPC1_PYRAB;  O58361, GTPC1_PYRHO;  
Q8XVA0, GTPC1_RALSO;  Q4V7D6, GTPC1_RAT;  P67271, GTPC1_SALTI;  
P67270, GTPC1_SALTY;  O94404, GTPC1_SCHPO;  Q5HFK1, GTPC1_STAAC;  
P67272, GTPC1_STAAM;  P67273, GTPC1_STAAN;  Q6GGE0, GTPC1_STAAR;  
Q6G907, GTPC1_STAAS;  Q8NWB9, GTPC1_STAAW;  Q5HNY9, GTPC1_STAEQ;  
Q8CSD9, GTPC1_STAES;  Q9L012, GTPC1_STRCO;  P67274, GTPC1_STRP1;  
P0DG84, GTPC1_STRP3;  Q5XCH0, GTPC1_STRP6;  P67276, GTPC1_STRP8;  
Q97PK0, GTPC1_STRPN;  P0DG85, GTPC1_STRPQ;  O83942, GTPC1_TREPA;  
Q9PQE0, GTPC1_UREPA;  Q9KQA7, GTPC1_VIBCH;  P53081, GTPC1_YEAST;  
Q8ZD91, GTPC1_YERPE;  

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