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ENZYME entry: EC

Accepted Name
8-oxo-dGDP phosphatase.
Reaction catalysed
8-oxo-dGDP + H(2)O <=> 8-oxo-dGMP + phosphate
  • The enzyme catalyzes the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage.
  • The preferred in vivo substrate is not known.
  • The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC
  • Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolyzed with broad specificity.
  • The bifunctional enzyme NUDT5 also hydrolyzes ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC
  • The human enzyme NUDT18 also hydrolyzes 8-oxo-dADP and 2-hydroxy- dADP, the latter at a slower rate.
PRIAM enzyme-specific profiles3.6.1.58
KEGG Ligand Database for Enzyme Nomenclature3.6.1.58
IUBMB Enzyme Nomenclature3.6.1.58
MEDLINEFind literature relating to
Q568Q0, NUD18_DANRE;  Q6ZVK8, NUD18_HUMAN;  Q3U2V3, NUD18_MOUSE;  

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