ENZYME entry: EC 3.6.1.58

Accepted Name
8-oxo-dGDP phosphatase.
Reaction catalysed
8-oxo-dGDP + H(2)O <=> 8-oxo-dGMP + phosphate
Comment(s)
  • The enzyme catalyzes the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage.
  • The preferred in vivo substrate is not known.
  • The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55).
  • Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolyzed with broad specificity.
  • The bifunctional enzyme NUDT5 also hydrolyzes ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13).
  • The human enzyme NUDT18 also hydrolyzes 8-oxo-dADP and 2-hydroxy- dADP, the latter at a slower rate.
Cross-references
BRENDA3.6.1.58
EC2PDB3.6.1.58
ExplorEnz3.6.1.58
PRIAM enzyme-specific profiles3.6.1.58
KEGG Ligand Database for Enzyme Nomenclature3.6.1.58
IUBMB Enzyme Nomenclature3.6.1.58
IntEnz3.6.1.58
MEDLINEFind literature relating to 3.6.1.58
MetaCyc3.6.1.58
UniProtKB/Swiss-Prot
Q568Q0, NUD18_DANRE;  Q6ZVK8, NUD18_HUMAN;  Q3U2V3, NUD18_MOUSE;  
Q641Y7, NUD18_RAT;  Q9UKK9, NUDT5_HUMAN;  Q9JKX6, NUDT5_MOUSE;  
Q5RCY2, NUDT5_PONAB;  Q6AY63, NUDT5_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
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