ENZYME entry: EC 3.6.1.62
| Accepted Name |
|---|
| M(7)GpppN-mRNA hydrolase.
|
| Reaction catalysed |
|---|
| M(7)G5'ppp5'-mRNA + H(2)O <=> m(7)GDP + 5'-phospho-mRNA |
| Comment(s) |
|---|
- Decapping of mRNA is a critical step in eukaryotic mRNA turnover.
- The enzyme is unable to cleave a free cap structure (m(7)GpppG).
- The enzyme from Vaccinia virus is synergistically activated in the
presence of Mg(2+) and Mn(2+).
- Formerly EC 3.6.1.30.
|
| Cross-references |
|---|
| BRENDA | 3.6.1.62 |
| EC2PDB | 3.6.1.62 |
| ExplorEnz | 3.6.1.62 |
| PRIAM enzyme-specific profiles | 3.6.1.62 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.6.1.62 |
| IUBMB Enzyme Nomenclature | 3.6.1.62 |
| IntEnz | 3.6.1.62 |
| MEDLINE | Find literature relating to 3.6.1.62 |
| MetaCyc | 3.6.1.62 |
| UniProtKB/Swiss-Prot |
| Q8GW31, DCP2_ARATH; | Q8IU60, DCP2_HUMAN; | Q9CYC6, DCP2_MOUSE; |
| Q5REQ8, DCP2_PONAB; | A1A4Q9, NUD16_BOVIN; | P0DKY8, NUD16_HOMVI; |
| Q96DE0, NUD16_HUMAN; | Q6P3D0, NUD16_MOUSE; | Q2V8X7, NUD16_SHEEP; |
| Q6TEC1, NUD16_XENLA; |
|
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