ENZYME entry: EC 4.1.1.31

Accepted Name
Phosphoenolpyruvate carboxylase.
Alternative Name(s)
PEP carboxylase.
PEPCase.
Phosphoenolpyruvic carboxylase.
Reaction catalysed
Phosphate + oxaloacetate <=> H(2)O + phosphoenolpyruvate + HCO(3)(-)
Comment(s)
  • This enzyme replenishes oxaloacetate in the tricarboxylic acid cycle when operating in the reverse direction.
  • The reaction proceeds in two steps: formation of carboxyphosphate and the enolate form of pyruvate, followed by carboxylation of the enolate and release of phosphate.
Cross-references
PROSITEPDOC00330
BRENDA4.1.1.31
EC2PDB4.1.1.31
ExplorEnz4.1.1.31
PRIAM enzyme-specific profiles4.1.1.31
KEGG Ligand Database for Enzyme Nomenclature4.1.1.31
IUBMB Enzyme Nomenclature4.1.1.31
IntEnz4.1.1.31
MEDLINEFind literature relating to 4.1.1.31
MetaCyc4.1.1.31
UniProtKB/Swiss-Prot
Q9MAH0, CAPP1_ARATH;  P81831, CAPP1_CHLRE;  Q01647, CAPP1_FLAPR;  
P04711, CAPP1_MAIZE;  P10490, CAPP1_MESCR;  P29193, CAPP1_SACHY;  
P29195, CAPP1_SORBI;  Q02909, CAPP1_SOYBN;  Q5GM68, CAPP2_ARATH;  
Q6R2V6, CAPP2_CHLRE;  P51059, CAPP2_MAIZE;  P16097, CAPP2_MESCR;  
P29194, CAPP2_SORBI;  P51061, CAPP2_SOYBN;  Q84VW9, CAPP3_ARATH;  
P15804, CAPP3_SORBI;  Q8GVE8, CAPP4_ARATH;  O28786, CAPPA_ARCFU;  
A8MBK0, CAPPA_CALMQ;  Q0TRE4, CAPPA_CLOP1;  Q8XLE8, CAPPA_CLOPE;  
Q0STS8, CAPPA_CLOPS;  P30694, CAPPA_FLATR;  B0R7F9, CAPPA_HALS3;  
Q9HN43, CAPPA_HALSA;  Q03VI7, CAPPA_LEUMM;  Q8TMG9, CAPPA_METAC;  
Q469A3, CAPPA_METBF;  Q2FLH1, CAPPA_METHJ;  Q8TYV1, CAPPA_METKA;  
Q8PS70, CAPPA_METMA;  A4YES9, CAPPA_METS5;  O27026, CAPPA_METTH;  
Q04D35, CAPPA_OENOB;  Q6L0F3, CAPPA_PICTO;  Q9V2Q9, CAPPA_PYRAB;  
Q8ZT64, CAPPA_PYRAE;  A4WJM7, CAPPA_PYRAR;  A3MVZ5, CAPPA_PYRCJ;  
Q8TZL5, CAPPA_PYRFU;  O57764, CAPPA_PYRHO;  A1RR50, CAPPA_PYRIL;  
Q4JCJ1, CAPPA_SULAC;  C3N0D7, CAPPA_SULIA;  C4KJI5, CAPPA_SULIK;  
C3MJE5, CAPPA_SULIL;  C3MTS7, CAPPA_SULIM;  C3NJA0, CAPPA_SULIN;  
C3N8C3, CAPPA_SULIY;  Q97WG4, CAPPA_SULSO;  Q96YS2, CAPPA_SULTO;  
A1RZN3, CAPPA_THEPD;  Q9FV66, CAPPB_FLATR;  Q9FV65, CAPPC_FLATR;  
Q6F6Q6, CAPP_ACIAD;  A3MA94, CAPP_ACIBT;  A3MZ57, CAPP_ACTP2;  
A0KFU8, CAPP_AERHH;  A4SIM0, CAPP_AERS4;  Q0VRS0, CAPP_ALCBS;  
B6EMN4, CAPP_ALISL;  Q43299, CAPP_AMAHP;  Q3MB82, CAPP_ANAVT;  
Q5P7H5, CAPP_AROAE;  A1R2V3, CAPP_ARTAT;  A8I060, CAPP_AZOC5;  
A1K454, CAPP_AZOSB;  Q7WQB3, CAPP_BORBR;  Q7WCA9, CAPP_BORPA;  
Q7W0D0, CAPP_BORPE;  Q89R17, CAPP_BRADU;  A3MLK7, CAPP_BURM7;  
A2SAH4, CAPP_BURM9;  Q62LC1, CAPP_BURMA;  A1V5U2, CAPP_BURMS;  
A3N6Z8, CAPP_BURP6;  Q63W75, CAPP_BURPS;  A4JGV5, CAPP_BURVG;  
Q143B6, CAPP_BURXL;  Q9A871, CAPP_CAUCR;  Q1QX15, CAPP_CHRSD;  
Q7P206, CAPP_CHRVO;  A8AKW6, CAPP_CITK8;  Q93MH3, CAPP_CORCT;  
P61448, CAPP_CORDI;  Q8RQL3, CAPP_COREF;  P12880, CAPP_CORGL;  
A7ZUH4, CAPP_ECO24;  B7UNT2, CAPP_ECO27;  B7MI92, CAPP_ECO45;  
B7LA56, CAPP_ECO55;  Q8X743, CAPP_ECO57;  B5Z058, CAPP_ECO5E;  
B7NU44, CAPP_ECO7I;  B7MR83, CAPP_ECO81;  B7M710, CAPP_ECO8A;  
C5A0C2, CAPP_ECOBW;  B1XBC1, CAPP_ECODH;  A8A764, CAPP_ECOHS;  
A1AID4, CAPP_ECOK1;  Q0TAA4, CAPP_ECOL5;  Q8FB98, CAPP_ECOL6;  
B1IVC2, CAPP_ECOLC;  P00864, CAPP_ECOLI;  B7NFQ6, CAPP_ECOLU;  
B6I5H2, CAPP_ECOSE;  B1LNR6, CAPP_ECOSM;  Q1R3V5, CAPP_ECOUT;  
C5BC63, CAPP_EDWI9;  A4WG55, CAPP_ENT38;  B2VGA2, CAPP_ERWT9;  
B7LUN9, CAPP_ESCF3;  Q7NNJ7, CAPP_GLOVI;  Q4QL71, CAPP_HAEI8;  
A5UCN0, CAPP_HAEIE;  A5UIY9, CAPP_HAEIG;  P43920, CAPP_HAEIN;  
Q2SL23, CAPP_HAHCH;  Q0I371, CAPP_HISS1;  B0UUJ3, CAPP_HISS2;  
B5XZ20, CAPP_KLEP3;  Q5FK38, CAPP_LACAC;  Q1GBD4, CAPP_LACDA;  
A8YVD9, CAPP_LACH4;  A1U2U4, CAPP_MARHV;  A6VUQ5, CAPP_MARMS;  
Q02735, CAPP_MEDSA;  Q49136, CAPP_METEA;  A0QHY0, CAPP_MYCA1;  
P46710, CAPP_MYCLE;  P61449, CAPP_MYCPA;  A0QWX4, CAPP_MYCS2;  
A0PPN8, CAPP_MYCUA;  Q5F5A9, CAPP_NEIG1;  Q9JWH1, CAPP_NEIMA;  
Q9JXG5, CAPP_NEIMB;  A1KWE0, CAPP_NEIMF;  Q0AH90, CAPP_NITEC;  
Q82WS3, CAPP_NITEU;  Q5YYG7, CAPP_NOCFA;  P28594, CAPP_NOSS1;  
Q9CN89, CAPP_PASMU;  P51062, CAPP_PEA;  Q6DAR6, CAPP_PECAS;  
C6DI86, CAPP_PECCP;  Q9AU12, CAPP_PHAVU;  Q7MAX5, CAPP_PHOLL;  
Q6LVH1, CAPP_PHOPR;  P51063, CAPP_PICAB;  A3PF64, CAPP_PROM0;  
A8G779, CAPP_PROM2;  A2BYV8, CAPP_PROM5;  Q318G7, CAPP_PROM9;  
Q7V9U4, CAPP_PROMA;  B4F183, CAPP_PROMH;  Q7V561, CAPP_PROMM;  
Q7UZT0, CAPP_PROMP;  A2BTF4, CAPP_PROMS;  Q48F34, CAPP_PSE14;  
A6V1A0, CAPP_PSEA7;  Q9HXV3, CAPP_PSEAE;  Q1IDV2, CAPP_PSEE4;  
Q4KHK5, CAPP_PSEF5;  Q3IBX6, CAPP_PSEHT;  A4XXP6, CAPP_PSEMY;  
A5W881, CAPP_PSEP1;  Q3KHE4, CAPP_PSEPF;  B0KS63, CAPP_PSEPG;  
Q88MR4, CAPP_PSEPK;  Q886R9, CAPP_PSESM;  Q4ZWV3, CAPP_PSEU2;  
A4VN44, CAPP_PSEU5;  A1SRH8, CAPP_PSYIN;  Q8XWW2, CAPP_RALSO;  
Q59757, CAPP_RHOMR;  Q2IU23, CAPP_RHOP2;  Q07QP5, CAPP_RHOP5;  
O32483, CAPP_RHOPA;  Q218E3, CAPP_RHOPB;  Q139X8, CAPP_RHOPS;  
A7NLR3, CAPP_ROSCS;  A9MI14, CAPP_SALAR;  Q57H97, CAPP_SALCH;  
B5FPX1, CAPP_SALDC;  B5QXQ1, CAPP_SALEP;  B5RF49, CAPP_SALG2;  
B4TCQ2, CAPP_SALHS;  B4T0W7, CAPP_SALNS;  Q5PK55, CAPP_SALPA;  
A9N0G6, CAPP_SALPB;  C0Q472, CAPP_SALPC;  B5BJN0, CAPP_SALPK;  
B4TQH2, CAPP_SALSV;  Q8Z307, CAPP_SALTI;  Q8ZKM0, CAPP_SALTY;  
A8GL86, CAPP_SERP5;  B0TL90, CAPP_SHEHH;  A3Q9C4, CAPP_SHELP;  
Q8EK30, CAPP_SHEON;  A8GZ16, CAPP_SHEPA;  A8G1A9, CAPP_SHESH;  
B2TWF1, CAPP_SHIB3;  Q31U32, CAPP_SHIBS;  Q32AB9, CAPP_SHIDS;  
Q0SY38, CAPP_SHIF8;  Q83IS7, CAPP_SHIFL;  Q3YV20, CAPP_SHISS;  
P29196, CAPP_SOLTU;  Q3K1U6, CAPP_STRA1;  Q8E647, CAPP_STRA3;  
Q8E0H2, CAPP_STRA5;  Q82HE3, CAPP_STRAW;  Q9RNU9, CAPP_STRCO;  
A8AW99, CAPP_STRGC;  Q8DV10, CAPP_STRMU;  Q9A0U7, CAPP_STRP1;  
Q04KL8, CAPP_STRP2;  P0DC98, CAPP_STRP3;  Q5XD52, CAPP_STRP6;  
Q8P1W7, CAPP_STRP8;  A2RFQ7, CAPP_STRPG;  Q97QX6, CAPP_STRPN;  
P0DC99, CAPP_STRPQ;  Q8DPW5, CAPP_STRR6;  A4VZZ0, CAPP_STRS2;  
A3CP10, CAPP_STRSV;  A4VTQ4, CAPP_STRSY;  Q5M0E6, CAPP_STRT1;  
Q5M4Z3, CAPP_STRT2;  Q03LA9, CAPP_STRTD;  P06516, CAPP_SYNP6;  
A5GIW5, CAPP_SYNPW;  Q7U4M0, CAPP_SYNPX;  P74299, CAPP_SYNY3;  
P0A3X5, CAPP_THEEB;  P51060, CAPP_THES7;  Q72L05, CAPP_THET2;  
Q5SKL7, CAPP_THET8;  P0A3X6, CAPP_THEVL;  P27154, CAPP_TOBAC;  
C4L7S3, CAPP_TOLAT;  A1WGR0, CAPP_VEREI;  Q9KNT4, CAPP_VIBCH;  
Q5E2E3, CAPP_VIBF1;  B5FBP8, CAPP_VIBFM;  Q87L54, CAPP_VIBPA;  
B7VLL5, CAPP_VIBTL;  Q8DCN2, CAPP_VIBVU;  Q7MH68, CAPP_VIBVY;  
Q8PP82, CAPP_XANAC;  Q3BXC4, CAPP_XANC5;  Q4UR00, CAPP_XANC8;  
Q8P336, CAPP_XANCP;  Q2NZE4, CAPP_XANOM;  Q5GW71, CAPP_XANOR;  
A1JI20, CAPP_YERE8;  A7FCZ7, CAPP_YERP3;  Q1CBV8, CAPP_YERPA;  
B2JZD9, CAPP_YERPB;  Q8ZA84, CAPP_YERPE;  Q1CNQ7, CAPP_YERPN;  
A4TRH7, CAPP_YERPP;  Q66G74, CAPP_YERPS;  B1JQ63, CAPP_YERPY;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-