ENZYME entry: EC 4.1.3.36
| Accepted Name |
|---|
| 1,4-dihydroxy-2-naphthoyl-CoA synthase.
|
| Alternative Name(s) |
|---|
| DHNA synthetase. |
| Dihydroxynaphthoic acid synthetase. |
| Naphthoate synthase. |
| o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing). |
| Reaction catalysed |
|---|
| 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA <=> 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O |
| Comment(s) |
|---|
- This enzyme is involved in the synthesis of 1,4-dihydroxy-2-
naphthoate, a branch point metabolite leading to the biosynthesis of
menaquinone (vitamin K(2), in bacteria), phylloquinone (vitamin K(1)
in plants), and many plant pigments.
- The coenzyme A group is subsequently removed from the product by
EC 3.1.2.28.
|
| Cross-references |
|---|
| PROSITE | PDOC00150 |
| BRENDA | 4.1.3.36 |
| EC2PDB | 4.1.3.36 |
| ExplorEnz | 4.1.3.36 |
| PRIAM enzyme-specific profiles | 4.1.3.36 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.3.36 |
| IUBMB Enzyme Nomenclature | 4.1.3.36 |
| IntEnz | 4.1.3.36 |
| MEDLINE | Find literature relating to 4.1.3.36 |
| MetaCyc | 4.1.3.36 |
| UniProtKB/Swiss-Prot |
| Q8GYN9, MENB_ARATH; | P23966, MENB_BACSU; | Q9TM10, MENB_CYACA; |
| P0ABU1, MENB_ECOL6; | P0ABU0, MENB_ECOLI; | P44960, MENB_HAEIN; |
| A0QRD3, MENB_MYCS2; | O06414, MENB_MYCTU; | Q9CLV5, MENB_PASMU; |
| Q7CQ56, MENB_SALTY; | Q5HH38, MENB_STAAC; | Q99V48, MENB_STAAM; |
| Q7A6A9, MENB_STAAN; | Q6GI37, MENB_STAAR; | Q6GAG7, MENB_STAAS; |
| Q8NXA0, MENB_STAAW; | Q5HQC3, MENB_STAEQ; | Q8CPQ4, MENB_STAES; |
| Q4L549, MENB_STAHJ; | Q49WG8, MENB_STAS1; |
|
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