ENZYME entry: EC 4.1.99.12

Accepted Name
3,4-dihydroxy-2-butanone-4-phosphate synthase.
Alternative Name(s)
DHBP synthase.
L-3,4-dihydroxybutan-2-one-4-phosphate synthase.
Reaction catalysed
D-ribulose 5-phosphate <=> formate + L-3,4-dihydroxybutan-2-one 4-phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5.
  • The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.
Cross-references
BRENDA4.1.99.12
EC2PDB4.1.99.12
ExplorEnz4.1.99.12
PRIAM enzyme-specific profiles4.1.99.12
KEGG Ligand Database for Enzyme Nomenclature4.1.99.12
IUBMB Enzyme Nomenclature4.1.99.12
IntEnz4.1.99.12
MEDLINEFind literature relating to 4.1.99.12
MetaCyc4.1.99.12
UniProtKB/Swiss-Prot
Q5A3V6, RIB3_CANAL;  Q8TG90, RIB3_MAGO7;  O60181, RIB3_SCHPO;  
Q99258, RIB3_YEAST;  P47924, RIBA1_ARATH;  Q6Z234, RIBA1_ORYSJ;  
Q6NLQ7, RIBA2_ARATH;  Q0E079, RIBA2_ORYSJ;  A3MZA2, RIBBA_ACTP2;  
B3H0P8, RIBBA_ACTP7;  B0BTN8, RIBBA_ACTPJ;  P50855, RIBBA_ACTPL;  
O66679, RIBBA_AQUAE;  A7Z675, RIBBA_BACA2;  C3P7P7, RIBBA_BACAA;  
C3LIX7, RIBBA_BACAC;  A0RIB3, RIBBA_BACAH;  P51695, RIBBA_BACAM;  
Q81MB6, RIBBA_BACAN;  B7JLW6, RIBBA_BACC0;  Q731I5, RIBBA_BACC1;  
B7IWM5, RIBBA_BACC2;  C1EQY5, RIBBA_BACC3;  B7HAY4, RIBBA_BACC4;  
B7HNM8, RIBBA_BACC7;  A7GSD5, RIBBA_BACCN;  B9IWX4, RIBBA_BACCQ;  
Q818X6, RIBBA_BACCR;  Q635H0, RIBBA_BACCZ;  Q5LHT1, RIBBA_BACFN;  
Q64YT3, RIBBA_BACFR;  Q6HE54, RIBBA_BACHK;  Q5WH08, RIBBA_BACSK;  
P17620, RIBBA_BACSU;  Q8A528, RIBBA_BACTN;  A6KWQ7, RIBBA_BACV8;  
A9VG50, RIBBA_BACWK;  C0ZKW2, RIBBA_BREBN;  Q9PLJ5, RIBBA_CHLMU;  
Q9Z734, RIBBA_CHLPN;  O84736, RIBBA_CHLTR;  A0Q3H7, RIBBA_CLONN;  
O24752, RIBBA_CORAM;  A4QEG9, RIBBA_CORGB;  Q8NQ52, RIBBA_CORGL;  
Q11WK6, RIBBA_CYTH3;  C5D3N0, RIBBA_GEOSW;  A0QI09, RIBBA_MYCA1;  
B1MCA4, RIBBA_MYCA9;  P0A5V1, RIBBA_MYCBO;  A1KIK4, RIBBA_MYCBP;  
C1AN60, RIBBA_MYCBT;  A4TC13, RIBBA_MYCGI;  B2HP67, RIBBA_MYCMM;  
Q741F1, RIBBA_MYCPA;  A5U2B7, RIBBA_MYCTA;  P9WHF0, RIBBA_MYCTO;  
P9WHF1, RIBBA_MYCTU;  A0PPL6, RIBBA_MYCUA;  A1T8K1, RIBBA_MYCVP;  
Q5YTP3, RIBBA_NOCFA;  A6LHN0, RIBBA_PARD8;  Q3B2I6, RIBBA_PELLD;  
B4SE30, RIBBA_PELPB;  B2RIG7, RIBBA_PORG3;  Q7MWK9, RIBBA_PORGI;  
B4S5Y8, RIBBA_PROA2;  A4SFY4, RIBBA_PROVI;  C0ZZE5, RIBBA_RHOE4;  
Q0S0K2, RIBBA_RHOSR;  A8LY38, RIBBA_SALAI;  A4X639, RIBBA_SALTO;  
Q5HF07, RIBBA_STAAC;  Q99TA0, RIBBA_STAAM;  Q7A511, RIBBA_STAAN;  
Q6GFT5, RIBBA_STAAR;  Q6G8G1, RIBBA_STAAS;  Q8NW14, RIBBA_STAAW;  
Q5HNE3, RIBBA_STAEQ;  Q8CNU2, RIBBA_STAES;  Q4L7B1, RIBBA_STAHJ;  
Q49YJ7, RIBBA_STAS1;  Q0AXM5, RIBBA_SYNWW;  P74104, RIBBA_SYNY3;  
Q9X2E6, RIBBA_THEMA;  B0KAI2, RIBBA_THEP3;  B0K0Y9, RIBBA_THEPX;  
B1H0I0, RIBBA_UNCTG;  A0KHV1, RIBB_AERHH;  A4SKH7, RIBB_AERS4;  
Q8UE66, RIBB_AGRT5;  Q9L6K8, RIBB_ALIFS;  O28173, RIBB_ARCFU;  
Q1LSL6, RIBB_BAUCH;  Q7VQQ4, RIBB_BLOFL;  Q7WDL7, RIBB_BORBR;  
Q7W2M1, RIBB_BORPA;  Q7VSF4, RIBB_BORPE;  B8D8L7, RIBB_BUCA5;  
P57167, RIBB_BUCAI;  Q8KA55, RIBB_BUCAP;  B8D6X1, RIBB_BUCAT;  
P59556, RIBB_BUCBP;  Q9PHU4, RIBB_CAMJE;  B3EEP4, RIBB_CHLL2;  
B3QWA4, RIBB_CHLT3;  Q7NQC4, RIBB_CHRVO;  A8APS7, RIBB_CITK8;  
A7FXH7, RIBB_CLOB1;  A5I603, RIBB_CLOBH;  A7GHE0, RIBB_CLOBL;  
A7MP95, RIBB_CROS8;  Q46TZ9, RIBB_CUPPJ;  B8FLF4, RIBB_DESAA;  
C6BVV4, RIBB_DESAD;  Q313P5, RIBB_DESAG;  C0QJB0, RIBB_DESAH;  
B8J4Q5, RIBB_DESDA;  Q6AQE3, RIBB_DESPS;  A4J2L3, RIBB_DESRM;  
Q72B63, RIBB_DESVH;  A1VD83, RIBB_DESVV;  A7ZRS4, RIBB_ECO24;  
B7UIV5, RIBB_ECO27;  B7MAC3, RIBB_ECO45;  B7LGI1, RIBB_ECO55;  
P0A7J1, RIBB_ECO57;  B5YR87, RIBB_ECO5E;  B7NJQ5, RIBB_ECO7I;  
B7N0J6, RIBB_ECO81;  B7LZJ1, RIBB_ECO8A;  C4ZQV9, RIBB_ECOBW;  
B1XG46, RIBB_ECODH;  A8A4J8, RIBB_ECOHS;  A1AFX0, RIBB_ECOK1;  
Q0TD60, RIBB_ECOL5;  Q8FDH9, RIBB_ECOL6;  B1ISB5, RIBB_ECOLC;  
P0A7J0, RIBB_ECOLI;  B7ND35, RIBB_ECOLU;  B6I413, RIBB_ECOSE;  
B1LF38, RIBB_ECOSM;  Q1R6T4, RIBB_ECOUT;  C5BHH8, RIBB_EDWI9;  
A4WEI2, RIBB_ENT38;  B2VGK1, RIBB_ERWT9;  B7LQC3, RIBB_ESCF3;  
Q4QMD5, RIBB_HAEI8;  A5UDW2, RIBB_HAEIE;  A5UHR8, RIBB_HAEIG;  
P44866, RIBB_HAEIN;  C4K8P2, RIBB_HAMD5;  Q7VJN5, RIBB_HELHP;  
Q9ZL40, RIBB_HELPJ;  O25484, RIBB_HELPY;  Q0I132, RIBB_HISS1;  
B0UX44, RIBB_HISS2;  B5XU43, RIBB_KLEP3;  A6TE29, RIBB_KLEP7;  
Q65W81, RIBB_MANSM;  Q8TT89, RIBB_METAC;  Q60364, RIBB_METJA;  
A2SQG6, RIBB_METLZ;  Q8PW86, RIBB_METMA;  O27543, RIBB_METTH;  
Q9JU97, RIBB_NEIMA;  Q9JZ77, RIBB_NEIMB;  Q8CWF6, RIBB_OCEIH;  
P57940, RIBB_PASMU;  Q6D8S3, RIBB_PECAS;  C6D9P9, RIBB_PECCP;  
Q3A668, RIBB_PELCD;  A1AKS6, RIBB_PELPD;  Q02008, RIBB_PHOLE;  
Q7N0C8, RIBB_PHOLL;  P51962, RIBB_PHOPO;  Q6LIW0, RIBB_PHOPR;  
B4EW41, RIBB_PROMH;  Q9HWX4, RIBB_PSEAE;  Q3IKS6, RIBB_PSEHT;  
Q88QG4, RIBB_PSEPK;  Q882G0, RIBB_PSESM;  Q8XQN1, RIBB_RALSO;  
Q2RS98, RIBB_RHORT;  B5F690, RIBB_SALA4;  A9MPW6, RIBB_SALAR;  
Q57JR5, RIBB_SALCH;  B5FHS9, RIBB_SALDC;  B5QZ31, RIBB_SALEP;  
B5REF3, RIBB_SALG2;  B4TI45, RIBB_SALHS;  B4T665, RIBB_SALNS;  
Q5PMU5, RIBB_SALPA;  A9N5X2, RIBB_SALPB;  C0PYW8, RIBB_SALPC;  
B5BG06, RIBB_SALPK;  B4TVS9, RIBB_SALSV;  P66033, RIBB_SALTI;  
P66032, RIBB_SALTY;  A8GJU0, RIBB_SERP5;  B8E3W7, RIBB_SHEB2;  
A3DAC1, RIBB_SHEB5;  A6WHL6, RIBB_SHEB8;  A9KVB7, RIBB_SHEB9;  
Q07WC1, RIBB_SHEFN;  B0TMY9, RIBB_SHEHH;  A3Q8W5, RIBB_SHELP;  
Q8EKF2, RIBB_SHEON;  A8GYS3, RIBB_SHEPA;  A4Y1N7, RIBB_SHEPC;  
B8CH19, RIBB_SHEPW;  A0KRF9, RIBB_SHESA;  A8G1K1, RIBB_SHESH;  
Q0HP01, RIBB_SHESM;  Q0I0H0, RIBB_SHESR;  A1RPZ7, RIBB_SHESW;  
B1KNY2, RIBB_SHEWM;  B2U1F0, RIBB_SHIB3;  Q31WZ1, RIBB_SHIBS;  
Q32BS1, RIBB_SHIDS;  Q0T0L7, RIBB_SHIF8;  P0A7J2, RIBB_SHIFL;  
Q3YXK0, RIBB_SHISS;  Q2NWD7, RIBB_SODGM;  O68249, RIBB_SULMU;  
C4LDD2, RIBB_TOLAT;  A5F159, RIBB_VIBC3;  Q9KKP2, RIBB_VIBCH;  
C3LWX2, RIBB_VIBCM;  P16448, RIBB_VIBHA;  Q87GR5, RIBB_VIBPA;  
B7VT10, RIBB_VIBSL;  Q8D485, RIBB_VIBVU;  Q7MFR0, RIBB_VIBVY;  
Q8D2W5, RIBB_WIGBR;  Q7M936, RIBB_WOLSU;  A1JQV2, RIBB_YERE8;  
A7FE82, RIBB_YERP3;  Q1C377, RIBB_YERPA;  B2K2H0, RIBB_YERPB;  
Q8ZI56, RIBB_YERPE;  A9R7D2, RIBB_YERPG;  Q1CMD1, RIBB_YERPN;  
A4THU2, RIBB_YERPP;  Q665V6, RIBB_YERPS;  B1JM30, RIBB_YERPY;  

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