To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 4.2.1.1

Accepted Name
Carbonic anhydrase.
Alternative Name(s)
Carbonate dehydratase.
Carbonate hydro-lyase.
Carbonic dehydratase.
Reaction catalysed
H(2)CO(3) <=> CO(2) + H(2)O
Cofactor(s)
Zn(2+).
Comment(s)
  • The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH.
  • It is widespread and found in archaea, bacteria, and eukaryotes.
  • Three distinct classes exist, and appear to have evolved independently.
Cross-references
PROSITEPDOC00146 ; PDOC00586
BRENDA4.2.1.1
EC2PDB4.2.1.1
ExplorEnz4.2.1.1
PRIAM enzyme-specific profiles4.2.1.1
KEGG Ligand Database for Enzyme Nomenclature4.2.1.1
IUBMB Enzyme Nomenclature4.2.1.1
IntEnz4.2.1.1
MEDLINEFind literature relating to 4.2.1.1
MetaCyc4.2.1.1
UniProtKB/Swiss-Prot
O04846, ATCA1_ARATH;  F4IHR4, ATCA2_ARATH;  Q9FYE3, ATCA3_ARATH;  
F4JIK2, ATCA4_ARATH;  F4HUC4, ATCA5_ARATH;  Q9SUB4, ATCA6_ARATH;  
Q8L817, ATCA7_ARATH;  Q9FM99, ATCA8_ARATH;  P27140, BCA1_ARATH;  
A8XKV0, BCA1_CAEBR;  Q22460, BCA1_CAEEL;  P42737, BCA2_ARATH;  
Q9ZUC2, BCA3_ARATH;  Q94CE4, BCA4_ARATH;  Q94CE3, BCA5_ARATH;  
Q9C6F5, BCA6_ARATH;  O43570, CAH12_HUMAN;  Q8CI85, CAH12_MOUSE;  
Q9MZ30, CAH12_RABIT;  Q8N1Q1, CAH13_HUMAN;  Q9D6N1, CAH13_MOUSE;  
Q9ULX7, CAH14_HUMAN;  Q9WVT6, CAH14_MOUSE;  Q99N23, CAH15_MOUSE;  
Q1LZA1, CAH1_BOVIN;  P83299, CAH1_CHIHA;  P20507, CAH1_CHLRE;  
P46512, CAH1_FLALI;  Q7M316, CAH1_GORGO;  P00917, CAH1_HORSE;  
P00915, CAH1_HUMAN;  B3A0P2, CAH1_LOTGI;  P00916, CAH1_MACMU;  
P35217, CAH1_MACNE;  Q8HY33, CAH1_MONDO;  P13634, CAH1_MOUSE;  
Q7M317, CAH1_PANTR;  P07452, CAH1_RABIT;  B0BNN3, CAH1_RAT;  
P48282, CAH1_SHEEP;  P00921, CAH2_BOVIN;  P07630, CAH2_CHICK;  
P24258, CAH2_CHLRE;  P46513, CAH2_FLALI;  P00918, CAH2_HUMAN;  
B3A0Q6, CAH2_LOTGI;  P00920, CAH2_MOUSE;  P00919, CAH2_RABIT;  
P27139, CAH2_RAT;  P00922, CAH2_SHEEP;  Q8UWA5, CAH2_TRIHK;  
Q3SZX4, CAH3_BOVIN;  Q27504, CAH3_CAEEL;  P07450, CAH3_HORSE;  
P07451, CAH3_HUMAN;  P16015, CAH3_MOUSE;  Q5S1S4, CAH3_PIG;  
P14141, CAH3_RAT;  Q95323, CAH4_BOVIN;  P22748, CAH4_HUMAN;  
Q64444, CAH4_MOUSE;  P48283, CAH4_RABIT;  P48284, CAH4_RAT;  
P35218, CAH5A_HUMAN;  P23589, CAH5A_MOUSE;  P43165, CAH5A_RAT;  
Q9Y2D0, CAH5B_HUMAN;  Q9QZA0, CAH5B_MOUSE;  Q66HG6, CAH5B_RAT;  
Q10462, CAH5_CAEEL;  P18915, CAH6_BOVIN;  Q865C0, CAH6_CANLF;  
P23280, CAH6_HUMAN;  P18761, CAH6_MOUSE;  P08060, CAH6_SHEEP;  
P43166, CAH7_HUMAN;  Q9ERQ8, CAH7_MOUSE;  Q16790, CAH9_HUMAN;  
Q8VHB5, CAH9_MOUSE;  P40880, CAHC_HORVU;  P17067, CAHC_PEA;  
P16016, CAHC_SPIOL;  P27141, CAHC_TOBAC;  P46510, CAHX_FLABI;  
P46511, CAHX_FLABR;  P46281, CAHX_FLAPR;  Q92051, CAHZ_DANRE;  
B8V7P3, CAH_ACRMI;  P54212, CAH_DUNSA;  O52535, CAH_KLEPN;  
P84537, CAH_LOBCS;  P40881, CAH_METTE;  Q50940, CAH_NEIGO;  
P94170, CAH_NOSS1;  Q6DAJ6, CAH_PECAS;  O52538, CAH_PECCA;  
Q5AJ71, CAN_CANAL;  P61517, CAN_ECOLI;  Q5BCC5, CAN_EMENI;  
P45148, CAN_HAEIN;  O94255, CAN_SCHPO;  P61518, CAN_SHIFL;  
P53615, CAN_YEAST;  P0ABF0, CYNT_ECO57;  P0ABE9, CYNT_ECOLI;  
Q9ZN54, CYNT_HELPJ;  O24855, CYNT_HELPY;  A0R566, CYNT_MYCS2;  
Q9I262, CYNT_PSEAE;  P83329, CYNT_STRTR;  P27134, CYNT_SYNE7;  
Q54735, CYNT_SYNY3;  Q9NL38, MA66_PINMA;  A0ZSF6, MAC1_CRANI;  
A0ZSF7, MAC2_CRANI;  A0ZSF2, MAF_PINFU;  A0ZSF3, MAM_PINMA;  
Q27908, MANA_PINFU;  A0ZSF4, MAP1_MIZYE;  A0ZSF5, MAP2_MIZYE;  
P9WPJ6, MTCA1_MYCTO;  P9WPJ7, MTCA1_MYCTU;  P9WPJ8, MTCA2_MYCTO;  
P9WPJ9, MTCA2_MYCTU;  Q84UV8, NEC3_NICLS;  O34872, YTIB_BACSU;  
O06983, YVDA_BACSU;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-