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ENZYME entry: EC 4.2.1.107

Accepted Name
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase.
Alternative Name(s)
D-3-hydroxyacyl-CoA dehydratase.
Reaction catalysed
(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA <=> (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O
Comment(s)
  • Forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity.
  • Involved in the beta-oxidation of the cholesterol side chain in the cholic-acid biosynthesis pathway.
Cross-references
BRENDA4.2.1.107
EC2PDB4.2.1.107
ExplorEnz4.2.1.107
PRIAM enzyme-specific profiles4.2.1.107
KEGG Ligand Database for Enzyme Nomenclature4.2.1.107
IUBMB Enzyme Nomenclature4.2.1.107
IntEnz4.2.1.107
MEDLINEFind literature relating to 4.2.1.107
MetaCyc4.2.1.107
UniProtKB/Swiss-Prot
P51659, DHB4_HUMAN;  P51660, DHB4_MOUSE;  P97852, DHB4_RAT;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-