ENZYME entry: EC 4.2.1.116

Accepted Name
3-hydroxypropionyl-CoA dehydratase.
Alternative Name(s)
3-hydroxypropanoate-CoA dehydratase.
3-hydroxypropionyl-CoA hydro-lyase.
Reaction catalysed
3-hydroxypropanoyl-CoA <=> acryloyl-CoA + H(2)O
Comment(s)
  • Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
  • The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA.
Cross-references
PROSITEPDOC00150
BRENDA4.2.1.116
EC2PDB4.2.1.116
ExplorEnz4.2.1.116
PRIAM enzyme-specific profiles4.2.1.116
KEGG Ligand Database for Enzyme Nomenclature4.2.1.116
IUBMB Enzyme Nomenclature4.2.1.116
IntEnz4.2.1.116
MEDLINEFind literature relating to 4.2.1.116
MetaCyc4.2.1.116
UniProtKB/Swiss-Prot
A4YI89, HPCD_METS5

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-