ENZYME entry: EC 4.2.1.140

Accepted Name
Gluconate/galactonate dehydratase.
Alternative Name(s)
Gluconate dehydratase.
Reaction catalysed
  • D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + H(2)O
  • D-galactonate <=> 2-dehydro-3-deoxy-D-galactonate + H(2)O
Cofactor(s)
Mg(2+).
Comment(s)
  • The enzyme is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway in Picrophilus torridus and via the branched variant of the Entner- Doudoroff pathway in Sulfolobus solfataricus.
  • In vitro it utilizes D-gluconate with 6-10 fold higher catalytic efficiency than D-galactonate.
  • Cf. EC 4.2.1.6 and EC 4.2.1.39.
Cross-references
BRENDA4.2.1.140
EC2PDB4.2.1.140
ExplorEnz4.2.1.140
PRIAM enzyme-specific profiles4.2.1.140
KEGG Ligand Database for Enzyme Nomenclature4.2.1.140
IUBMB Enzyme Nomenclature4.2.1.140
IntEnz4.2.1.140
MEDLINEFind literature relating to 4.2.1.140
MetaCyc4.2.1.140
UniProtKB/Swiss-Prot
Q6L1T2, GAD_PICTO;  Q97U27, GAD_SULSO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-