To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 4.2.1.152

Accepted Name
Hydroperoxy icosatetraenoate dehydratase.
Alternative Name(s)
Epidermal lipoxygenase-3.
Reaction catalysed
A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O
Cofactor(s)
Fe(2+).
Comment(s)
  • The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE).
  • The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency.
  • The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE).
  • The enzymes also catalyze the reaction of EC 5.4.4.7.
Cross-references
BRENDA4.2.1.152
EC2PDB4.2.1.152
ExplorEnz4.2.1.152
PRIAM enzyme-specific profiles4.2.1.152
KEGG Ligand Database for Enzyme Nomenclature4.2.1.152
IUBMB Enzyme Nomenclature4.2.1.152
IntEnz4.2.1.152
MEDLINEFind literature relating to 4.2.1.152
MetaCyc4.2.1.152
UniProtKB/Swiss-Prot
Q9BYJ1, LOXE3_HUMAN;  Q9WV07, LOXE3_MOUSE;  D3ZKX9, LOXE3_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-