ENZYME entry: EC 4.2.1.152

Accepted Name
Hydroperoxy icosatetraenoate dehydratase.
Alternative Name(s)
Epidermal lipoxygenase-3.
Reaction catalysed
A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O
Cofactor(s)
Fe(2+).
Comment(s)
  • The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE).
  • The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency.
  • The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE).
  • The enzymes also catalyze the reaction of EC 5.4.4.7.
Cross-references
BRENDA4.2.1.152
EC2PDB4.2.1.152
ExplorEnz4.2.1.152
PRIAM enzyme-specific profiles4.2.1.152
KEGG Ligand Database for Enzyme Nomenclature4.2.1.152
IUBMB Enzyme Nomenclature4.2.1.152
IntEnz4.2.1.152
MEDLINEFind literature relating to 4.2.1.152
MetaCyc4.2.1.152
UniProtKB/Swiss-Prot
Q9BYJ1, LOXE3_HUMAN;  Q9WV07, LOXE3_MOUSE;  D3ZKX9, LOXE3_RAT;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
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