ENZYME entry: EC 4.2.1.17

Accepted Name
Enoyl-CoA hydratase.
Alternative Name(s)
Enoyl hydrase.
Unsaturated acyl-CoA hydratase.
Reaction catalysed
(3S)-3-hydroxyacyl-CoA <=> trans-2(or 3)-enoyl-CoA + H(2)O
Comment(s)
  • Acts in the reverse direction.
  • With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).
Cross-references
PROSITEPDOC00150
BRENDA4.2.1.17
EC2PDB4.2.1.17
ExplorEnz4.2.1.17
PRIAM enzyme-specific profiles4.2.1.17
KEGG Ligand Database for Enzyme Nomenclature4.2.1.17
IUBMB Enzyme Nomenclature4.2.1.17
IntEnz4.2.1.17
MEDLINEFind literature relating to 4.2.1.17
MetaCyc4.2.1.17
UniProtKB/Swiss-Prot
Q9ZPI6, AIM1_ARATH;  Q7U004, ECH12_MYCBO;  P53526, ECH12_MYCLE;  
P9WNN6, ECH12_MYCTO;  P9WNN7, ECH12_MYCTU;  P64019, ECH14_MYCBO;  
P9WNN4, ECH14_MYCTO;  P9WNN5, ECH14_MYCTU;  A0QJH8, ECH17_MYCA1;  
Q7TXE1, ECH17_MYCBO;  A1KN36, ECH17_MYCBP;  Q73VC7, ECH17_MYCPA;  
A5U753, ECH17_MYCTA;  P9WNN2, ECH17_MYCTO;  P9WNN3, ECH17_MYCTU;  
Q7U2S5, ECH1_MYCBO;  P9WNP2, ECH1_MYCTO;  P9WNP3, ECH1_MYCTU;  
P64015, ECHA6_MYCBO;  Q50130, ECHA6_MYCLE;  P9WNP0, ECHA6_MYCTO;  
P9WNP1, ECHA6_MYCTU;  P64017, ECHA8_MYCBO;  O07137, ECHA8_MYCLE;  
P9WNN8, ECHA8_MYCTO;  P9WNN9, ECHA8_MYCTU;  P40939, ECHA_HUMAN;  
Q8BMS1, ECHA_MOUSE;  Q29554, ECHA_PIG;  Q64428, ECHA_RAT;  
Q52995, ECHH_RHIME;  P24162, ECHH_RHOCB;  Q58DM8, ECHM_BOVIN;  
P34559, ECHM_CAEEL;  Q1ZXF1, ECHM_DICDI;  P30084, ECHM_HUMAN;  
Q8BH95, ECHM_MOUSE;  Q5R646, ECHM_PONAB;  P14604, ECHM_RAT;  
P55100, ECHP_CAVPO;  Q6NYL3, ECHP_DANRE;  Q08426, ECHP_HUMAN;  
Q9DBM2, ECHP_MOUSE;  Q5R5M8, ECHP_PONAB;  P07896, ECHP_RAT;  
Q4UL32, FAD3_RICFE;  Q9ZCZ1, FAD3_RICPR;  Q68WH7, FAD3_RICTY;  
Q6FF68, FADB_ACIAD;  B7H1I0, FADB_ACIB3;  B7I3P1, FADB_ACIB5;  
B2I2J9, FADB_ACIBC;  B0VLX4, FADB_ACIBS;  B0VE45, FADB_ACIBY;  
A0KEL1, FADB_AERHH;  A4STF2, FADB_AERS4;  B6EGU2, FADB_ALISL;  
P94549, FADB_BACSU;  A8ACZ4, FADB_CITK8;  Q489W3, FADB_COLP3;  
A7MQP0, FADB_CROS8;  A7ZU51, FADB_ECO24;  B7UNH4, FADB_ECO27;  
B7MHD1, FADB_ECO45;  B7L9A7, FADB_ECO55;  Q8X8I2, FADB_ECO57;  
B5YY93, FADB_ECO5E;  B7NV20, FADB_ECO7I;  B7N2F2, FADB_ECO81;  
B7M649, FADB_ECO8A;  C5A020, FADB_ECOBW;  B1XAK8, FADB_ECODH;  
A8A6V1, FADB_ECOHS;  Q0TAL0, FADB_ECOL5;  Q8FBI2, FADB_ECOL6;  
B1IW61, FADB_ECOLC;  P21177, FADB_ECOLI;  B7NFE7, FADB_ECOLU;  
B6I4I6, FADB_ECOSE;  B1LM32, FADB_ECOSM;  Q1R466, FADB_ECOUT;  
A4WFX4, FADB_ENT38;  Q9F0Y7, FADB_ENTCL;  B7LTY9, FADB_ESCF3;  
Q5QXH7, FADB_IDILO;  B5XYH0, FADB_KLEP3;  A6TGM4, FADB_KLEP7;  
Q6DAP5, FADB_PECAS;  Q7MZ92, FADB_PHOLL;  Q6LW06, FADB_PHOPR;  
Q48GW3, FADB_PSE14;  A6V382, FADB_PSEA7;  B7UYR6, FADB_PSEA8;  
Q02PH8, FADB_PSEAB;  Q9HZJ2, FADB_PSEAE;  Q1I7D4, FADB_PSEE4;  
Q4KFC4, FADB_PSEF5;  P28793, FADB_PSEFR;  C3K613, FADB_PSEFS;  
A4XSM8, FADB_PSEMY;  Q93Q12, FADB_PSEOL;  A5W6H0, FADB_PSEP1;  
Q3K9D8, FADB_PSEPF;  B0KH74, FADB_PSEPG;  Q88L02, FADB_PSEPK;  
Q9AHY3, FADB_PSEPU;  B1J5A5, FADB_PSEPW;  Q87ZB2, FADB_PSESM;  
Q4ZRA0, FADB_PSEU2;  A4VKA3, FADB_PSEU5;  Q4FQC6, FADB_PSYA2;  
Q1Q8J9, FADB_PSYCK;  A5WH99, FADB_PSYWF;  B5EZW0, FADB_SALA4;  
Q57HM6, FADB_SALCH;  B5QW85, FADB_SALEP;  B5RFL6, FADB_SALG2;  
B4SZ85, FADB_SALNS;  Q5PKQ2, FADB_SALPA;  A9MYB0, FADB_SALPB;  
B5BIZ0, FADB_SALPK;  B4TNZ1, FADB_SALSV;  Q8Z3C6, FADB_SALTI;  
Q9L6L5, FADB_SALTY;  A8G8D1, FADB_SERP5;  A1S1I8, FADB_SHEAM;  
B8E3R3, FADB_SHEB2;  A3CYJ4, FADB_SHEB5;  A6WHA0, FADB_SHEB8;  
A9KU91, FADB_SHEB9;  Q08A39, FADB_SHEFN;  B0TLB9, FADB_SHEHH;  
A3Q8U4, FADB_SHELP;  Q8EKR9, FADB_SHEON;  A8GYG0, FADB_SHEPA;  
A4Y1B6, FADB_SHEPC;  B8CH91, FADB_SHEPW;  A0KR50, FADB_SHESA;  
A8FP63, FADB_SHESH;  Q0HPB7, FADB_SHESM;  Q0I0T3, FADB_SHESR;  
A1RDW6, FADB_SHESW;  B1KCZ3, FADB_SHEWM;  B2TVJ5, FADB_SHIB3;  
Q32A21, FADB_SHIDS;  Q0SZ36, FADB_SHIF8;  Q83PG1, FADB_SHIFL;  
Q3YVC1, FADB_SHISS;  A5F465, FADB_VIBC3;  A7N1D2, FADB_VIBCB;  
Q9KNI1, FADB_VIBCH;  C3LSI3, FADB_VIBCM;  Q5E8X6, FADB_VIBF1;  
B5FEW8, FADB_VIBFM;  Q87TN9, FADB_VIBPA;  B7VGL4, FADB_VIBSL;  
Q8DDK6, FADB_VIBVU;  Q7MQH9, FADB_VIBVY;  A1JIG4, FADB_YERE8;  
A7FDF2, FADB_YERP3;  Q1C2C4, FADB_YERPA;  B2K0Z6, FADB_YERPB;  
Q8ZAN0, FADB_YERPE;  A9R754, FADB_YERPG;  Q1CN99, FADB_YERPN;  
A4TR27, FADB_YERPP;  Q66FR8, FADB_YERPS;  B1JP63, FADB_YERPY;  
A8ADP2, FADJ_CITK8;  A7MH81, FADJ_CROS8;  A7ZPF8, FADJ_ECO24;  
B7UFZ8, FADJ_ECO27;  B7MGV7, FADJ_ECO45;  B7LBJ5, FADJ_ECO55;  
Q8XCP2, FADJ_ECO57;  B5YXY4, FADJ_ECO5E;  B7NP24, FADJ_ECO7I;  
B7MY16, FADJ_ECO81;  B7M6M2, FADJ_ECO8A;  C4ZVN2, FADJ_ECOBW;  
B1X9L4, FADJ_ECODH;  A8A2L0, FADJ_ECOHS;  A1ADI8, FADJ_ECOK1;  
Q0TFA6, FADJ_ECOL5;  Q8FFG4, FADJ_ECOL6;  B1IXA5, FADJ_ECOLC;  
P77399, FADJ_ECOLI;  B7N5V2, FADJ_ECOLU;  B6I6Q4, FADJ_ECOSE;  
B1LME7, FADJ_ECOSM;  Q1R972, FADJ_ECOUT;  A4WCW6, FADJ_ENT38;  
B7LLD0, FADJ_ESCF3;  Q5QXM1, FADJ_IDILO;  B5XVW2, FADJ_KLEP3;  
A6TC19, FADJ_KLEP7;  Q6D2L7, FADJ_PECAS;  C6DAL7, FADJ_PECCP;  
Q7N288, FADJ_PHOLL;  Q6LTK3, FADJ_PHOPR;  B5EZR9, FADJ_SALA4;  
Q57LW6, FADJ_SALCH;  B5FPN1, FADJ_SALDC;  B5R3R9, FADJ_SALEP;  
B5RCL3, FADJ_SALG2;  B4TCA8, FADJ_SALHS;  B4SZR0, FADJ_SALNS;  
Q5PCX6, FADJ_SALPA;  A9N453, FADJ_SALPB;  B5BBA1, FADJ_SALPK;  
B4TQC2, FADJ_SALSV;  Q8Z4Z0, FADJ_SALTI;  Q8ZNA7, FADJ_SALTY;  
A8GH86, FADJ_SERP5;  A1S7L6, FADJ_SHEAM;  A3D684, FADJ_SHEB5;  
A6WQ25, FADJ_SHEB8;  Q07ZP8, FADJ_SHEFN;  B0TL21, FADJ_SHEHH;  
A3QFP3, FADJ_SHELP;  Q8ECP7, FADJ_SHEON;  A4Y897, FADJ_SHEPC;  
A0KV76, FADJ_SHESA;  Q0HKD1, FADJ_SHESM;  Q0HWN3, FADJ_SHESR;  
A1RI92, FADJ_SHESW;  B2TWV4, FADJ_SHIB3;  Q31YB7, FADJ_SHIBS;  
Q32DJ4, FADJ_SHIDS;  Q0T2E6, FADJ_SHIF8;  Q83QQ0, FADJ_SHIFL;  
Q3YZM2, FADJ_SHISS;  A5F2P2, FADJ_VIBC3;  A7MS61, FADJ_VIBCB;  
Q9KT58, FADJ_VIBCH;  Q5E3U1, FADJ_VIBF1;  Q87MM3, FADJ_VIBPA;  
Q8DB47, FADJ_VIBVU;  Q7MIS5, FADJ_VIBVY;  A1JK30, FADJ_YERE8;  
A7FGK1, FADJ_YERP3;  Q1C660, FADJ_YERPA;  Q8ZD45, FADJ_YERPE;  
Q1CHK2, FADJ_YERPN;  A4TM82, FADJ_YERPP;  Q668V1, FADJ_YERPS;  
Q9ZPI5, MFP2_ARATH;  O49809, MFPA_BRANA;  Q39659, MFPA_CUCSA;  
Q8W1L6, MFP_ORYSJ;  P76082, PAAF_ECOLI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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