ENZYME entry: EC 4.2.1.24

Accepted Name
Porphobilinogen synthase.
Alternative Name(s)
Aminolevulinate dehydratase.
Delta-aminolevulinic acid dehydratase.
Reaction catalysed
2 5-aminolevulinate <=> porphobilinogen + 2 H(2)O
Cofactor(s)
Zn(2+).
Comment(s)
  • The enzyme catalyzes the asymmetric condensation and cyclization of two 5-aminolevulinate molecules, which is the first common step in the biosynthesis of tetrapyrrole pigments such as porphyrin, chlorophyll, vitamin B12, siroheme, phycobilin, and cofactor F430.
  • The enzyme is widespread, being essential in organisms that carry out respiration, photosynthesis, or methanogenesis.
  • In humans, the enzyme is a primary target for the environmental toxin Pb.
  • The enzymes from some organisms utilize a dynamic equilibrium between architecturally distinct multimeric assemblies as a means for allosteric regulation.
Cross-references
PROSITEPDOC00153
BRENDA4.2.1.24
EC2PDB4.2.1.24
ExplorEnz4.2.1.24
PRIAM enzyme-specific profiles4.2.1.24
KEGG Ligand Database for Enzyme Nomenclature4.2.1.24
IUBMB Enzyme Nomenclature4.2.1.24
IntEnz4.2.1.24
MEDLINEFind literature relating to 4.2.1.24
MetaCyc4.2.1.24
UniProtKB/Swiss-Prot
Q9SFH9, HEM21_ARATH;  Q94LA4, HEM22_ARATH;  O67876, HEM2_AQUAE;  
O28305, HEM2_ARCFU;  Q750E0, HEM2_ASHGO;  Q9K8G2, HEM2_BACHD;  
P30950, HEM2_BACSU;  Q58DK5, HEM2_BOVIN;  P45622, HEM2_BRADU;  
O42768, HEM2_CANGA;  Q9PLU4, HEM2_CHLMU;  Q59334, HEM2_CHLP8;  
Q9Z7G1, HEM2_CHLPN;  Q42682, HEM2_CHLRE;  Q8KCJ0, HEM2_CHLTE;  
O84638, HEM2_CHLTR;  Q59295, HEM2_CLOJO;  Q55E06, HEM2_DICDI;  
P0ACB2, HEM2_ECOLI;  Q9ZMR8, HEM2_HELPJ;  P56074, HEM2_HELPY;  
Q42836, HEM2_HORVU;  P13716, HEM2_HUMAN;  Q60HH9, HEM2_MACFA;  
Q60178, HEM2_METJA;  Q02250, HEM2_METSC;  O26839, HEM2_METTH;  
P10518, HEM2_MOUSE;  P46723, HEM2_MYCLE;  P9WMP4, HEM2_MYCTO;  
P9WMP5, HEM2_MYCTU;  Q5Z8V9, HEM2_ORYSJ;  P30124, HEM2_PEA;  
Q43058, HEM2_PHYPA;  Q5R971, HEM2_PONAB;  P77923, HEM2_PROFF;  
Q59643, HEM2_PSEAE;  P06214, HEM2_RAT;  P42504, HEM2_RHOCA;  
P78974, HEM2_SCHPO;  P45623, HEM2_SELMA;  P0ACB3, HEM2_SHIFL;  
P43210, HEM2_SOYBN;  P24493, HEM2_SPIOL;  Q2FXR3, HEM2_STAA8;  
Q5HFA4, HEM2_STAAC;  P64333, HEM2_STAAM;  P64334, HEM2_STAAN;  
Q6GG37, HEM2_STAAR;  Q6G8Q7, HEM2_STAAS;  P0C1R9, HEM2_STAAU;  
P64335, HEM2_STAAW;  Q5HNN5, HEM2_STAEQ;  Q8CNZ0, HEM2_STAES;  
P54919, HEM2_STRCO;  P43087, HEM2_SYNE7;  P77969, HEM2_SYNY3;  
P05373, HEM2_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-