ENZYME entry: EC 4.2.1.27
| Accepted Name |
|---|
| Acetylenecarboxylate hydratase.
|
| Alternative Name(s) |
|---|
| Acetylenemonocarboxylate hydratase. |
| Alkynoate hydratase. |
| Malonate-semialdehyde dehydratase. |
| Reaction catalysed |
|---|
| 3-oxopropanoate <=> propynoate + H(2)O |
| Comment(s) |
|---|
- The reaction is effectively irreversible, favoring oxopropanoate
(malonic semialdehyde) and its tautomers.
- Also acts on but-3-ynoate forming acetoacetate.
- The mechanism appears to involve hydration of the acetylene to
3-hydroxypropenoate, which will spontaneously tautomerize to
3-oxopropanoate.
- It is thus analogous to EC 4.1.1.78 in its mechanism.
- Formerly EC 4.2.1.71.
|
| Cross-references |
|---|
| BRENDA | 4.2.1.27 |
| EC2PDB | 4.2.1.27 |
| ExplorEnz | 4.2.1.27 |
| PRIAM enzyme-specific profiles | 4.2.1.27 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.1.27 |
| IUBMB Enzyme Nomenclature | 4.2.1.27 |
| IntEnz | 4.2.1.27 |
| MEDLINE | Find literature relating to 4.2.1.27 |
| MetaCyc | 4.2.1.27 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-