ENZYME entry: EC 4.2.1.96

Accepted Name
4a-hydroxytetrahydrobiopterin dehydratase.
Alternative Name(s)
4-alpha-hydroxy-tetrahydropterin dehydratase.
Pterin-4-alpha-carbinolamine dehydratase.
Tetrahydrobiopterin dehydratase.
Reaction catalysed
(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin <=> (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O
Comment(s)
Catalyzes the dehydration of 4a-hydroxytetrahydrobiopterins.
Cross-references
BRENDA4.2.1.96
EC2PDB4.2.1.96
ExplorEnz4.2.1.96
PRIAM enzyme-specific profiles4.2.1.96
KEGG Ligand Database for Enzyme Nomenclature4.2.1.96
IUBMB Enzyme Nomenclature4.2.1.96
IntEnz4.2.1.96
MEDLINEFind literature relating to 4.2.1.96
MetaCyc4.2.1.96
UniProtKB/Swiss-Prot
Q475Y4, PHS1_CUPPJ;  Q7NM43, PHS1_GLOVI;  Q9DG45, PHS2_CHICK;  
Q46VT8, PHS2_CUPPJ;  Q7NK35, PHS2_GLOVI;  Q9H0N5, PHS2_HUMAN;  
Q9CZL5, PHS2_MOUSE;  Q5R7K1, PHS2_PONAB;  A1TND7, PHS_ACIAC;  
C1F425, PHS_ACIC5;  A5FWK8, PHS_ACICJ;  A0KJG4, PHS_AERHH;  
A4SNJ1, PHS_AERS4;  B9JCJ2, PHS_AGRRK;  Q8UC22, PHS_AGRT5;  
B9JUA0, PHS_AGRVS;  A6TVX6, PHS_ALKMQ;  B4RXT2, PHS_ALTMD;  
Q3MA60, PHS_ANAVT;  O66462, PHS_AQUAE;  Q5P905, PHS_AROAE;  
A1K7V8, PHS_AZOSB;  C1DQH9, PHS_AZOVD;  P61732, PHS_BDEBA;  
Q2KXB6, PHS_BORA1;  Q7WG14, PHS_BORBR;  Q7W4J0, PHS_BORPA;  
Q7VU17, PHS_BORPE;  Q3ZBD3, PHS_BOVIN;  Q89WZ6, PHS_BRADU;  
A5E8P9, PHS_BRASB;  A4YJY8, PHS_BRASO;  B2S7X9, PHS_BRUA1;  
Q2YNV0, PHS_BRUA2;  Q57FT6, PHS_BRUAB;  A9M6T4, PHS_BRUC2;  
C0RGE2, PHS_BRUMB;  P65722, PHS_BRUME;  A5VN26, PHS_BRUO2;  
B0CIJ4, PHS_BRUSI;  P65723, PHS_BRUSU;  B1YQ64, PHS_BURA4;  
B1K1I7, PHS_BURCC;  A0K2V4, PHS_BURCH;  B4E566, PHS_BURCJ;  
Q0BJP4, PHS_BURCM;  Q39L06, PHS_BURL3;  A9AJD5, PHS_BURM1;  
Q62FU4, PHS_BURMA;  Q3JXT0, PHS_BURP1;  B2T7M8, PHS_BURPP;  
Q63PF1, PHS_BURPS;  A4JA07, PHS_BURVG;  Q13SM2, PHS_BURXL;  
Q9TZH6, PHS_CAEEL;  B8GYB5, PHS_CAUCN;  Q9ABI2, PHS_CAUCR;  
B0T207, PHS_CAUSK;  Q11D07, PHS_CHESB;  O73930, PHS_CHICK;  
A9WI69, PHS_CHLAA;  B8G3F7, PHS_CHLAD;  B3ECB9, PHS_CHLL2;  
B3QQ83, PHS_CHLP8;  B9LCC8, PHS_CHLSY;  Q8KFI4, PHS_CHLTE;  
Q1QXY2, PHS_CHRSD;  Q7NVH7, PHS_CHRVO;  Q47XN8, PHS_COLP3;  
B8HU56, PHS_CYAP4;  Q11PN9, PHS_CYTH3;  Q47IX1, PHS_DECAR;  
Q54RY8, PHS_DICDI;  A8LKP0, PHS_DINSH;  O76454, PHS_DROME;  
P58249, PHS_DROVI;  A0M1H4, PHS_GRAFK;  Q2SCE8, PHS_HAHCH;  
A1WWH9, PHS_HALHL;  B9LPE3, PHS_HALLT;  Q5V1I9, PHS_HALMA;  
B0R6B9, PHS_HALS3;  Q9HP73, PHS_HALSA;  A9AXS2, PHS_HERA2;  
P61457, PHS_HUMAN;  P0C8L6, PHS_HYPDU;  Q5QU19, PHS_IDILO;  
Q28VA7, PHS_JANSC;  Q1IP68, PHS_KORVE;  Q5X3Q4, PHS_LEGPA;  
A5IDI1, PHS_LEGPC;  Q5ZU09, PHS_LEGPH;  Q5WV42, PHS_LEGPL;  
A1TZA3, PHS_MARHV;  A6VSD2, PHS_MARMS;  Q60BH8, PHS_METCA;  
A4YEM3, PHS_METS5;  B0JQV0, PHS_MICAN;  P61458, PHS_MOUSE;  
A0QCA6, PHS_MYCA1;  B1MLG8, PHS_MYCA9;  P0A5S3, PHS_MYCBO;  
A1KHV0, PHS_MYCBP;  C1AMF4, PHS_MYCBT;  B8ZRQ6, PHS_MYCLB;  
Q9CBX1, PHS_MYCLE;  P61733, PHS_MYCPA;  A0R2K7, PHS_MYCS2;  
A3Q4G7, PHS_MYCSJ;  A1UKF3, PHS_MYCSK;  Q1B4N5, PHS_MYCSS;  
A5U1K8, PHS_MYCTA;  P9WI92, PHS_MYCTO;  P9WI93, PHS_MYCTU;  
A1TDS4, PHS_MYCVP;  Q3ISB3, PHS_NATPD;  Q0ADS7, PHS_NITEC;  
Q82Y13, PHS_NITEU;  Q1QHE0, PHS_NITHX;  Q2YB52, PHS_NITMU;  
Q3J910, PHS_NITOC;  Q3SNS9, PHS_NITWN;  Q5YQC8, PHS_NOCFA;  
B2IVV2, PHS_NOSP7;  Q8YNL6, PHS_NOSS1;  Q2G9B0, PHS_NOVAD;  
A6WV21, PHS_OCHA4;  B6JAT9, PHS_OLICO;  B1ZY08, PHS_OPITP;  
A1B3I3, PHS_PARDP;  A7HSX5, PHS_PARL1;  Q3A282, PHS_PELCD;  
Q3B6N5, PHS_PELLD;  B4SAU0, PHS_PELPB;  B4RBN1, PHS_PHEZH;  
Q6LI45, PHS_PHOPR;  A3PBL6, PHS_PROM0;  A8G3K7, PHS_PROM2;  
A2C7K4, PHS_PROM3;  A2BVF3, PHS_PROM5;  Q31C42, PHS_PROM9;  
Q7VD93, PHS_PROMA;  Q7V689, PHS_PROMM;  Q7V2I5, PHS_PROMP;  
A2BPX4, PHS_PROMS;  Q46GT1, PHS_PROMT;  Q48G05, PHS_PSE14;  
A6VAA4, PHS_PSEA7;  B7UY63, PHS_PSEA8;  Q02I31, PHS_PSEAB;  
P43335, PHS_PSEAE;  Q1I6Y2, PHS_PSEE4;  Q4KG97, PHS_PSEF5;  
C3K0W5, PHS_PSEFS;  Q3IIZ3, PHS_PSEHT;  A5W0C1, PHS_PSEP1;  
Q3KG65, PHS_PSEPF;  B0KRW3, PHS_PSEPG;  Q88EH2, PHS_PSEPK;  
B1JCI6, PHS_PSEPW;  Q885L1, PHS_PSESM;  Q4ZQG4, PHS_PSEU2;  
A4VQE0, PHS_PSEU5;  Q4FVF3, PHS_PSYA2;  A1SSU3, PHS_PSYIN;  
B2UGY6, PHS_RALPJ;  Q8XU38, PHS_RALSO;  P61459, PHS_RAT;  
Q2K3A7, PHS_RHIEC;  Q1MAM8, PHS_RHIL3;  Q98E92, PHS_RHILO;  
B5ZTF5, PHS_RHILW;  Q92L66, PHS_RHIME;  C3MAI8, PHS_RHISN;  
Q2J3Z9, PHS_RHOP2;  Q07N39, PHS_RHOP5;  P61734, PHS_RHOPA;  
Q214W1, PHS_RHOPB;  Q13D98, PHS_RHOPS;  B3Q9E4, PHS_RHOPT;  
Q2RNC0, PHS_RHORT;  Q3IZF4, PHS_RHOS4;  A8GYB5, PHS_RICB8;  
Q1RGM6, PHS_RICBR;  A8EXY4, PHS_RICCK;  Q4UKS5, PHS_RICFE;  
A7NS25, PHS_ROSCS;  Q16BN1, PHS_ROSDO;  A5UPS5, PHS_ROSS1;  
Q1AUE0, PHS_RUBXD;  Q5LM31, PHS_RUEPO;  Q1GDR0, PHS_RUEST;  
Q21MC6, PHS_SACD2;  O42658, PHS_SCHPO;  A1S7S0, PHS_SHEAM;  
B8E7N1, PHS_SHEB2;  A3D2P0, PHS_SHEB5;  A6WLE1, PHS_SHEB8;  
A9KVE9, PHS_SHEB9;  Q12L03, PHS_SHEDO;  Q084Y3, PHS_SHEFN;  
B0TNB2, PHS_SHEHH;  A3QCV5, PHS_SHELP;  Q8EGD7, PHS_SHEON;  
A8H2I7, PHS_SHEPA;  A4Y581, PHS_SHEPC;  B8CLA1, PHS_SHEPW;  
A0KYY8, PHS_SHESA;  Q0HGZ0, PHS_SHESM;  Q0HT97, PHS_SHESR;  
A1RLI8, PHS_SHESW;  B1KMK3, PHS_SHEWM;  A6UE17, PHS_SINMW;  
Q01VX3, PHS_SOLUE;  A5V667, PHS_SPHWW;  Q82M02, PHS_STRAW;  
O86722, PHS_STRCO;  B4SPV4, PHS_STRM5;  B2FM88, PHS_STRMK;  
Q4J6J6, PHS_SULAC;  C3MZU9, PHS_SULIA;  C4KJC1, PHS_SULIK;  
C3MTL3, PHS_SULIM;  Q97WM6, PHS_SULSO;  Q96YL0, PHS_SULTO;  
B1XN71, PHS_SYNP2;  A5GMR6, PHS_SYNPW;  Q7U5B3, PHS_SYNPX;  
Q0I8H5, PHS_SYNS3;  P73790, PHS_SYNY3;  Q8DHW8, PHS_THEEB;  
B9L1Y8, PHS_THERP;  Q31HZ6, PHS_THICR;  Q3SHT9, PHS_THIDA;  
Q116J2, PHS_TRIEI;  A5F0J0, PHS_VIBC3;  A7N3S9, PHS_VIBCB;  
Q9KLB9, PHS_VIBCH;  C3LW91, PHS_VIBCM;  Q87IM9, PHS_VIBPA;  
Q8D6S1, PHS_VIBVU;  Q7MDN2, PHS_VIBVY;  Q8PKQ3, PHS_XANAC;  
Q3BSV4, PHS_XANC5;  Q4UUW5, PHS_XANC8;  B0RTH5, PHS_XANCB;  
Q8P8Z8, PHS_XANCP;  Q2P1A2, PHS_XANOM;  B2STN6, PHS_XANOP;  
Q5GYA0, PHS_XANOR;  Q91901, PHS_XENLA;  B2I9W6, PHS_XYLF2;  
Q9PAB4, PHS_XYLFA;  B0U5V4, PHS_XYLFM;  Q87A51, PHS_XYLFT;  
P38744, PHS_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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