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ENZYME entry: EC 126.96.36.199
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|Chondroitin ABC eliminase.|
|Chondroitin ABC lyase.|
|Chondroitin sulfate ABC exoeliminase.|
|Chondroitin sulfate ABC exolyase.|
|Chondroitin sulfate ABC lyase.|
|ChS ABC lyase.|
|ChS ABC lyase II.|
|Exolytic removal of Delta(4)-unsaturated disaccharide residues from the non-reducing ends of both polymeric chondroitin/dermatan sulfates and their oligosaccharide fragments|
- Degrades a variety of glycosaminoglycans of the chondroitin-sulfate-
and dermatan-sulfate type.
- Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan
sulfate are the best substrates but the enzyme can also act on
hyaluronan at a much lower rate.
- The related enzyme EC 188.8.131.52 has the same substrate specificity but
produces a mixture of oligosaccharides of different sizes that are
ultimately degraded to tetra- and disaccharides.
- Both enzymes act by the removal of a relatively acidic C-5 proton of
the uronic acid followed by the elimination of a 4-linked hexosamine,
resulting in the formation of an unsaturated C4-C5 bond on the
hexuronic acid moiety of the products.
- Formerly EC 184.108.40.206 and EC 220.127.116.11.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
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entries corresponding to 4.2.2.-
entries corresponding to 4.2.-.-
entries corresponding to 4.-.-.-