Expasy logo

ENZYME

ENZYME entry: EC 4.2.3.108

Accepted Name
1,8-cineole synthase
Alternative Name(s)
1,8-cineole cyclase
Reaction catalysed
(2E)-geranyl diphosphate + H2O <=> 1,8-cineole + diphosphate
Comment(s)
  • 1,8-cineole is the main product from the enzyme with just traces of other monoterpenoids.
  • The oxygen atom is derived from water.
  • The reaction proceeds via linalyl diphosphate and alpha-terpineol, the stereochemistry of both depends on the organism.
  • However neither intermediate can substitute for geranyl diphosphate.
  • The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)- linalyl diphosphate while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate.
Cross-references
BRENDA4.2.3.108
EC2PDB4.2.3.108
ExplorEnz4.2.3.108
PRIAM enzyme-specific profiles4.2.3.108
KEGG Ligand Database for Enzyme Nomenclature4.2.3.108
IUBMB Enzyme Nomenclature4.2.3.108
IntEnz4.2.3.108
MEDLINEFind literature relating to 4.2.3.108
MetaCyc4.2.3.108
Rhea expert-curated reactions4.2.3.108
UniProtKB/Swiss-Prot
R9QMZ0, ATERP_PINCOP0DI76, CIN1_ARATHP0DI77, CIN2_ARATH
F2XFA2, CINES_PICGLC0PT35, CINES_PICSIF2XF98, CINES_PICXS
A6XH05, CINS1_SALFTA5Y5L5, CIN_NICSUB5GMG2, CNSA_STRCL
O81191, SCS_SALOFH6WZF2, TER_NICALH2ELN1, TER_NICLA

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-