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ENZYME entry: EC 4.2.3.9

Accepted Name
Aristolochene synthase.
Alternative Name(s)
Sesquiterpene cyclase.
Trans,trans-farnesyl diphosphate aristolochene-lyase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate <=> aristolochene + diphosphate
Cofactor(s)
Mg(2+); Mn(2+).
Comment(s)
  • The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene.
  • While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23).
  • Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi.
  • Formerly EC 2.5.1.40 and EC 4.1.99.7.
Cross-references
BRENDA4.2.3.9
EC2PDB4.2.3.9
ExplorEnz4.2.3.9
PRIAM enzyme-specific profiles4.2.3.9
KEGG Ligand Database for Enzyme Nomenclature4.2.3.9
IUBMB Enzyme Nomenclature4.2.3.9
IntEnz4.2.3.9
MEDLINEFind literature relating to 4.2.3.9
MetaCyc4.2.3.9
UniProtKB/Swiss-Prot
Q9UR08, ARIS_ASPTE;  Q03471, PRX2_PENRO;  B6H063, PRX2_PENRW;  

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