ENZYME entry: EC 4.3.1.19

Accepted Name
Threonine ammonia-lyase.
Alternative Name(s)
L-serine dehydratase.
L-threonine deaminase.
L-threonine dehydratase.
L-threonine hydro-lyase (deaminating).
Serine deaminase.
Threonine deaminase.
Threonine dehydrase.
Threonine dehydratase.
Reaction catalysed
L-threonine <=> 2-oxobutanoate + NH(3)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The protein from Pseudomonas putida does not require pyridoxal- phosphate.
  • The enzyme from a number of sources also acts on L-serine, cf. EC 4.3.1.17.
  • The reaction catalyzed probably involves initial elimination of water (hence the enzyme's original classification as EC 4.2.1.16), followed by isomerization and hydrolysis of the product with C-N bond breakage.
  • Formerly EC 4.2.1.16.
Cross-references
PROSITEPDOC00149
BRENDA4.3.1.19
EC2PDB4.3.1.19
ExplorEnz4.3.1.19
PRIAM enzyme-specific profiles4.3.1.19
KEGG Ligand Database for Enzyme Nomenclature4.3.1.19
IUBMB Enzyme Nomenclature4.3.1.19
IntEnz4.3.1.19
MEDLINEFind literature relating to 4.3.1.19
MetaCyc4.3.1.19
UniProtKB/Swiss-Prot
Q0VCW4, SDHL_BOVIN;  P20132, SDHL_HUMAN;  Q8VBT2, SDHL_MOUSE;  
P09367, SDHL_RAT;  Q96GA7, SDSL_HUMAN;  Q8R238, SDSL_MOUSE;  
P25379, STDH_YEAST;  Q9ZSS6, THD1_ARATH;  Q9KC63, THD1_BACHD;  
P37946, THD1_BACSU;  P53607, THD1_BURM1;  Q39469, THD1_CICAR;  
Q04513, THD1_CORGL;  P04968, THD1_ECOLI;  P46493, THD1_HAEIN;  
Q02145, THD1_LACLA;  P66898, THD1_MYCBO;  Q9X7F1, THD1_MYCLE;  
P66897, THD1_MYCTU;  Q9CKJ2, THD1_PASMU;  P20506, THD1_SALTY;  
P25306, THD1_SOLLC;  P31212, THD1_SOLTU;  Q2FF63, THD1_STAA3;  
Q2FWJ9, THD1_STAA8;  Q2YUE8, THD1_STAAB;  Q5HEE0, THD1_STAAC;  
Q99SJ1, THD1_STAAM;  Q7A4H2, THD1_STAAN;  Q3V7T5, THD1_STAAR;  
Q3V7T4, THD1_STAAS;  Q8NVI8, THD1_STAAW;  Q5HMF5, THD1_STAEQ;  
Q8CNK9, THD1_STAES;  Q4L7U4, THD1_STAHJ;  Q49Z16, THD1_STAS1;  
P0AGF8, THD2_ECO57;  P0AGF7, THD2_ECOL6;  P0AGF6, THD2_ECOLI;  
P11954, THD2_SALTY;  P0AGF9, THD2_SHIFL;  Q2FH01, THD2_STAA3;  
Q2FYJ3, THD2_STAA8;  Q2YY67, THD2_STAAB;  Q5HFY5, THD2_STAAC;  
Q99U50, THD2_STAAM;  Q7A5L8, THD2_STAAN;  Q6GGX0, THD2_STAAR;  
Q6G9C4, THD2_STAAS;  Q8NWQ4, THD2_STAAW;  O42615, THDH_BLAAD;  
O94634, THDH_SCHPO;  P00927, THDH_YEAST;  P55664, Y4TJ_RHISN;  

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