ENZYME entry: EC 4.4.1.16

Accepted Name
Selenocysteine lyase.
Alternative Name(s)
Selenocysteine beta-lyase.
Selenocysteine reductase.
Reaction catalysed
L-selenocysteine + reduced acceptor <=> selenide + L-alanine + acceptor
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Dithiothreitol or 2-mercaptoethanol can act as the reducing agent in the reaction.
  • The enzyme from animals does not act on cysteine, serine or chloroalanine, while the enzyme from bacteria shows activity with cysteine (cf. EC 2.8.1.7).
Cross-references
BRENDA4.4.1.16
EC2PDB4.4.1.16
ExplorEnz4.4.1.16
PRIAM enzyme-specific profiles4.4.1.16
KEGG Ligand Database for Enzyme Nomenclature4.4.1.16
IUBMB Enzyme Nomenclature4.4.1.16
IntEnz4.4.1.16
MEDLINEFind literature relating to 4.4.1.16
MetaCyc4.4.1.16
UniProtKB/Swiss-Prot
Q46925, CSDA_ECOLI;  Q93WX6, NFS2_ARATH;  A2VDS1, SCLY_BOVIN;  
Q96I15, SCLY_HUMAN;  Q9JLI6, SCLY_MOUSE;  Q68FT9, SCLY_RAT;  
Q66IQ6, SCLY_XENLA;  Q5U4Q9, SCLY_XENTR;  A8AH80, SUFS_CITK8;  
A7MF59, SUFS_CROS8;  Q9EXP2, SUFS_DICD3;  A7ZME5, SUFS_ECO24;  
B7US19, SUFS_ECO27;  B7MA32, SUFS_ECO45;  B7L5N2, SUFS_ECO55;  
Q7ADI4, SUFS_ECO57;  B5Z4B3, SUFS_ECO5E;  B7NTV6, SUFS_ECO7I;  
B7MV59, SUFS_ECO81;  B7M0N5, SUFS_ECO8A;  C4ZYE2, SUFS_ECOBW;  
B1XFY8, SUFS_ECODH;  A8A0M6, SUFS_ECOHS;  A1ABL8, SUFS_ECOK1;  
Q0THE9, SUFS_ECOL5;  Q8FH54, SUFS_ECOL6;  B1IQ76, SUFS_ECOLC;  
P77444, SUFS_ECOLI;  B7N516, SUFS_ECOLU;  B6IBB9, SUFS_ECOSE;  
B1LE56, SUFS_ECOSM;  Q1RBB6, SUFS_ECOUT;  A4W9R3, SUFS_ENT38;  
B7LQ96, SUFS_ESCF3;  B5XQH2, SUFS_KLEP3;  A6TAE4, SUFS_KLEP7;  
Q6D625, SUFS_PECAS;  C6DKM6, SUFS_PECCP;  Q7N3U5, SUFS_PHOLL;  
B5F7C4, SUFS_SALA4;  A9MEP3, SUFS_SALAR;  Q57PR2, SUFS_SALCH;  
B5FIM3, SUFS_SALDC;  B5QVS9, SUFS_SALEP;  B5RAT4, SUFS_SALG2;  
B4TGK9, SUFS_SALHS;  B4T4R6, SUFS_SALNS;  A9N142, SUFS_SALPB;  
B4TUT5, SUFS_SALSV;  Q8XF77, SUFS_SALTI;  Q7CQN5, SUFS_SALTY;  
A8GDU4, SUFS_SERP5;  B2U2I4, SUFS_SHIB3;  Q321D9, SUFS_SHIBS;  
Q7UAH4, SUFS_SHIFL;  Q3Z233, SUFS_SHISS;  Q8D2J7, SUFS_WIGBR;  
A7FHJ2, SUFS_YERP3;  Q1C761, SUFS_YERPA;  B2K5J4, SUFS_YERPB;  
Q8D0M6, SUFS_YERPE;  A9QZC9, SUFS_YERPG;  Q1CIJ6, SUFS_YERPN;  
A4TIP2, SUFS_YERPP;  Q66A22, SUFS_YERPS;  B1JJ48, SUFS_YERPY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
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