ENZYME entry: EC 4.4.1.6

Accepted Name
S-alkylcysteine lyase.
Alternative Name(s)
S-alkyl-L-cysteinase.
S-alkyl-L-cysteine alkylthiol-lyase (deaminating).
S-alkyl-L-cysteine lyase.
S-alkyl-L-cysteine sulfoxide lyase.
Reaction catalysed
An S-alkyl-L-cysteine + H(2)O <=> an alkyl thiol + NH(3) + pyruvate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Decomposes S-alkyl-L-cysteines by alpha,beta-elimination.
  • The enzyme cleaves a carbon-sulfur bond, releasing an alkyl thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • Possibly identical, in Saccharomyces cerevisiae, with EC 4.4.1.8.
Cross-references
BRENDA4.4.1.6
EC2PDB4.4.1.6
ExplorEnz4.4.1.6
PRIAM enzyme-specific profiles4.4.1.6
KEGG Ligand Database for Enzyme Nomenclature4.4.1.6
IUBMB Enzyme Nomenclature4.4.1.6
IntEnz4.4.1.6
MEDLINEFind literature relating to 4.4.1.6
MetaCyc4.4.1.6

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-