ENZYME entry: EC 5.3.1.5

Accepted Name
Xylose isomerase.
Alternative Name(s)
D-xylose ketoisomerase.
Reaction catalysed
D-xylopyranose <=> D-xylulose
Cofactor(s)
Magnesium.
Comment(s)
  • The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity.
  • The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites.
  • Isomerization proceeds via a hydride-shift mechanism.
Cross-references
PROSITEPDOC00156
BRENDA5.3.1.5
EC2PDB5.3.1.5
ExplorEnz5.3.1.5
PRIAM enzyme-specific profiles5.3.1.5
KEGG Ligand Database for Enzyme Nomenclature5.3.1.5
IUBMB Enzyme Nomenclature5.3.1.5
IntEnz5.3.1.5
MEDLINEFind literature relating to 5.3.1.5
MetaCyc5.3.1.5
UniProtKB/Swiss-Prot
Q8PLL9, XYLA1_XANAC;  Q4UTU6, XYLA1_XANC8;  Q8P9T9, XYLA1_XANCP;  
Q5GYQ7, XYLA1_XANOR;  Q8PEW5, XYLA2_XANAC;  Q4UNZ4, XYLA2_XANC8;  
Q8P3H1, XYLA2_XANCP;  Q5GUF2, XYLA2_XANOR;  P12851, XYLA_ACTM4;  
A3N3K2, XYLA_ACTP2;  B3H2X9, XYLA_ACTP7;  B0BTI9, XYLA_ACTPJ;  
P10654, XYLA_ACTS3;  A6VLM8, XYLA_ACTSZ;  B9JAF5, XYLA_AGRRK;  
Q8U7G6, XYLA_AGRT5;  B9JSR6, XYLA_AGRVS;  Q9FKK7, XYLA_ARATH;  
B8HA51, XYLA_ARTCA;  A0JXN9, XYLA_ARTS2;  P12070, XYLA_ARTS7;  
A7Z522, XYLA_BACA2;  Q739D2, XYLA_BACC1;  Q5LCV9, XYLA_BACFN;  
Q64U20, XYLA_BACFR;  Q9K993, XYLA_BACHD;  P77832, XYLA_BACLD;  
O08325, XYLA_BACMD;  A8FE33, XYLA_BACP2;  E0TVS5, XYLA_BACPZ;  
Q5WKJ3, XYLA_BACSK;  P0CI80, XYLA_BACSU;  P54272, XYLA_BACSW;  
Q8A9M2, XYLA_BACTN;  A6L792, XYLA_BACV8;  A1A0H0, XYLA_BIFAA;  
B3DR33, XYLA_BIFLD;  Q8G3Q1, XYLA_BIFLO;  Q89VC7, XYLA_BRADU;  
B2SA37, XYLA_BRUA1;  Q2YMQ2, XYLA_BRUA2;  Q57EI4, XYLA_BRUAB;  
A9M9H3, XYLA_BRUC2;  C0RHQ0, XYLA_BRUMB;  Q8YFX5, XYLA_BRUME;  
A5VPA1, XYLA_BRUO2;  B0CKM9, XYLA_BRUSI;  Q8G204, XYLA_BRUSU;  
B1Z405, XYLA_BURA4;  Q1BG90, XYLA_BURCA;  B1KB47, XYLA_BURCC;  
A0KE56, XYLA_BURCH;  B4ENA5, XYLA_BURCJ;  Q0B1U7, XYLA_BURCM;  
A9ARG7, XYLA_BURM1;  B2JFE9, XYLA_BURP8;  B2T929, XYLA_BURPP;  
Q2SW40, XYLA_BURTA;  A4JSU5, XYLA_BURVG;  Q13RB8, XYLA_BURXL;  
B9MPG8, XYLA_CALBD;  A5CPC1, XYLA_CLAM3;  B0RIF1, XYLA_CLAMS;  
A7MNI5, XYLA_CROS8;  A8LP53, XYLA_DINSH;  A7ZTB2, XYLA_ECO24;  
B7ULC6, XYLA_ECO27;  B7MES1, XYLA_ECO45;  B7L6Y0, XYLA_ECO55;  
Q7A9X4, XYLA_ECO57;  B5YVL8, XYLA_ECO5E;  B7NP65, XYLA_ECO7I;  
B7N1L9, XYLA_ECO81;  B7M3I8, XYLA_ECO8A;  C4ZXF6, XYLA_ECOBW;  
B1X8I1, XYLA_ECODH;  A8A623, XYLA_ECOHS;  Q0TBN7, XYLA_ECOL5;  
Q8FCE3, XYLA_ECOL6;  B1IZM7, XYLA_ECOLC;  P00944, XYLA_ECOLI;  
B7NEL7, XYLA_ECOLU;  B6I3D6, XYLA_ECOSE;  B1LJC7, XYLA_ECOSM;  
A4W566, XYLA_ENT38;  Q7C3R3, XYLA_ENTFA;  B7LTH9, XYLA_ESCF3;  
Q6T6K9, XYLA_FERGO;  Q5KYS6, XYLA_GEOKA;  P54273, XYLA_GEOSE;  
A4IP67, XYLA_GEOTN;  Q4QLI2, XYLA_HAEI8;  A5UCZ3, XYLA_HAEIE;  
A5UIN7, XYLA_HAEIG;  P44398, XYLA_HAEIN;  B0UT19, XYLA_HISS2;  
Q40082, XYLA_HORVU;  P29442, XYLA_KLEPN;  Q03TX3, XYLA_LACBA;  
P29443, XYLA_LACBR;  Q9CFG7, XYLA_LACLA;  Q02Y75, XYLA_LACLS;  
P21938, XYLA_LACPE;  A0AF79, XYLA_LISW6;  Q65PY0, XYLA_MANSM;  
A6VWH1, XYLA_MARMS;  Q11EH9, XYLA_MESSB;  Q2GAB9, XYLA_NOVAD;  
Q8ELU7, XYLA_OCEIH;  A6X4G3, XYLA_OCHA4;  Q6DB05, XYLA_PECAS;  
C6DIH5, XYLA_PECCP;  Q03HN1, XYLA_PEDPA;  Q7N4P7, XYLA_PHOLL;  
Q6LUY7, XYLA_PHOPR;  Q48J73, XYLA_PSE14;  Q15PG0, XYLA_PSEA6;  
C3K8E3, XYLA_PSEFS;  Q3KDW0, XYLA_PSEPF;  Q880Z4, XYLA_PSESM;  
Q4ZSF5, XYLA_PSEU2;  B3Q0R5, XYLA_RHIE6;  Q2K433, XYLA_RHIEC;  
Q1MBL8, XYLA_RHIL3;  Q98CR8, XYLA_RHILO;  B5ZQV6, XYLA_RHILW;  
Q92LW9, XYLA_RHIME;  C3M8Y0, XYLA_RHISN;  Q7UVG2, XYLA_RHOBA;  
A3PNM4, XYLA_RHOS1;  Q3IYM4, XYLA_RHOS4;  A4WVT8, XYLA_RHOS5;  
B9KPP8, XYLA_RHOSK;  Q162B6, XYLA_ROSDO;  Q5LV46, XYLA_RUEPO;  
Q1GKQ4, XYLA_RUEST;  Q9S306, XYLA_RUMFL;  B5EX72, XYLA_SALA4;  
Q57IG0, XYLA_SALCH;  B5FLD6, XYLA_SALDC;  B5R4P8, XYLA_SALEP;  
B5RGL6, XYLA_SALG2;  B4T952, XYLA_SALHS;  B4SWK9, XYLA_SALNS;  
Q5PLM6, XYLA_SALPA;  A9MUV0, XYLA_SALPB;  C0Q1C2, XYLA_SALPC;  
B4TZ55, XYLA_SALSV;  Q7C637, XYLA_SALTI;  Q8ZL90, XYLA_SALTY;  
A8G7W8, XYLA_SERP5;  B2U560, XYLA_SHIB3;  Q31V53, XYLA_SHIBS;  
Q3YVV0, XYLA_SHISS;  A6UD89, XYLA_SINMW;  Q022S9, XYLA_SOLUE;  
P27157, XYLA_STAXY;  P24299, XYLA_STRAL;  Q93HF3, XYLA_STRAW;  
Q9S3Z4, XYLA_STRCK;  Q9L0B8, XYLA_STRCO;  P50910, XYLA_STRDI;  
Q9RFM4, XYLA_STRLI;  P37031, XYLA_STRMR;  Q93RJ9, XYLA_STROI;  
P15587, XYLA_STROL;  P22857, XYLA_STRRO;  P24300, XYLA_STRRU;  
P19149, XYLA_STRS8;  Q9L558, XYLA_STRTM;  P14405, XYLA_STRVN;  
P09033, XYLA_STRVO;  O82845, XYLA_TETHA;  P56681, XYLA_THECA;  
Q9X1Z5, XYLA_THEMA;  P45687, XYLA_THENE;  B9K7G3, XYLA_THENN;  
A5ILR5, XYLA_THEP1;  P22842, XYLA_THEP3;  B0K1L3, XYLA_THEPX;  
P30435, XYLA_THESA;  B1LB08, XYLA_THESQ;  P26997, XYLA_THET8;  
P29441, XYLA_THETC;  P19148, XYLA_THETU;  Q9KGU2, XYLA_THEYO;  
Q3BMF2, XYLA_XANC5;  Q2NXR2, XYLA_XANOM;  A1JT10, XYLA_YERE8;  
A7FP68, XYLA_YERP3;  Q1C0D3, XYLA_YERPA;  B2K7D2, XYLA_YERPB;  
Q8Z9Z1, XYLA_YERPE;  A9R5Q1, XYLA_YERPG;  Q1CDB8, XYLA_YERPN;  
A4TS63, XYLA_YERPP;  Q663Y3, XYLA_YERPS;  B1JH40, XYLA_YERPY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.-.-
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