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ENZYME entry: EC

Accepted Name
Pyrrolysine--tRNA(Pyl) ligase.
Alternative Name(s)
Pyrrolysyl-tRNA synthetase.
Reaction catalysed
ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)
  • In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNA(Pyl), with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl- -tRNA ligase.
  • Specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids.
PRIAM enzyme-specific profiles6.1.1.26
KEGG Ligand Database for Enzyme Nomenclature6.1.1.26
IUBMB Enzyme Nomenclature6.1.1.26
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.-.-
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