ENZYME entry: EC 6.1.1.26
| Accepted Name |
|---|
| Pyrrolysine--tRNA(Pyl) ligase.
|
| Alternative Name(s) |
|---|
| PylRS. |
| Pyrrolysyl-tRNA synthetase. |
| Reaction catalysed |
|---|
| ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl) |
| Comment(s) |
|---|
- In organisms such as Methanosarcina barkeri that incorporate the
modified amino acid pyrrolysine (Pyl) into certain methylamine
methyltransferases, an unusual tRNA(Pyl), with a CUA anticodon,
can be charged directly with pyrrolysine by this class II aminoacyl-
-tRNA ligase.
- Specific for pyrrolysine as substrate as it cannot be replaced by
lysine or any of the other natural amino acids.
|
| Cross-references |
|---|
| BRENDA | 6.1.1.26 |
| EC2PDB | 6.1.1.26 |
| ExplorEnz | 6.1.1.26 |
| PRIAM enzyme-specific profiles | 6.1.1.26 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.1.1.26 |
| IUBMB Enzyme Nomenclature | 6.1.1.26 |
| IntEnz | 6.1.1.26 |
| MEDLINE | Find literature relating to 6.1.1.26 |
| MetaCyc | 6.1.1.26 |
| UniProtKB/Swiss-Prot |
|
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