ENZYME entry: EC 6.1.1.27

Accepted Name
O-phosphoserine--tRNA ligase.
Alternative Name(s)
O-phosphoseryl-tRNA ligase.
SepRS.
Reaction catalysed
ATP + O-phospho-L-serine + tRNA(Cys) <=> AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)
Comment(s)
  • In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 for the direct Cys-tRNA(Cys) formation, Cys-tRNA(Cys) is produced by an indirect pathway, in which EC 6.1.1.27 ligates O-phosphoserine to tRNA(Cys), and EC 2.5.1.73 converts the produced O-phospho-L-seryl- tRNA(Cys) to Cys-tRNA(Cys).
  • The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism.
  • Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73.
  • Formerly EC 6.1.1.n2.
Cross-references
PROSITEPDOC00363
BRENDA6.1.1.27
EC2PDB6.1.1.27
ExplorEnz6.1.1.27
PRIAM enzyme-specific profiles6.1.1.27
KEGG Ligand Database for Enzyme Nomenclature6.1.1.27
IUBMB Enzyme Nomenclature6.1.1.27
IntEnz6.1.1.27
MEDLINEFind literature relating to 6.1.1.27
MetaCyc6.1.1.27
UniProtKB/Swiss-Prot
O30126, SEPS_ARCFU;  A6UVW6, SEPS_META3;  Q8TUH7, SEPS_METAC;  
A7I4Y4, SEPS_METB6;  Q46D71, SEPS_METBF;  Q12XG0, SEPS_METBU;  
Q2FSR2, SEPS_METHJ;  Q59054, SEPS_METJA;  Q8TY66, SEPS_METKA;  
A2SQV5, SEPS_METLZ;  A4FYB1, SEPS_METM5;  A9A794, SEPS_METM6;  
A6VJZ5, SEPS_METM7;  Q8PX39, SEPS_METMA;  A3CXN8, SEPS_METMJ;  
Q6LZE1, SEPS_METMP;  B8GJL9, SEPS_METPE;  O27545, SEPS_METTH;  
A0B632, SEPS_METTP;  A6USJ0, SEPS_METVS;  Q0W0T4, SEPS_UNCMA;  

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