To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 6.2.1.7

Accepted Name
Cholate--CoA ligase.
Alternative Name(s)
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase.
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP- forming).
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase.
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase.
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase.
BAL.
Bile acid CoA ligase.
Bile acid coenzyme A ligase.
Cholate thiokinase.
Cholic acid:CoA ligase.
Cholic thiokinase.
Choloyl coenzyme A synthetase.
Choloyl-CoA synthetase.
Cholyl-CoA synthetase.
THCA-CoA ligase.
Trihydroxycoprostanoyl-CoA synthetase.
Reaction catalysed
  • ATP + cholate + CoA <=> AMP + diphosphate + choloyl-CoA
  • ATP + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oate + CoA <=> AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA
Cofactor(s)
Mg(2+).
Comment(s)
  • This membrane-bound enzyme catalyzes the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters.
  • The second step involves EC 2.3.1.65 and converts the acyl-CoA thioester into the corresponding N-acyl amidate by conjugation with glycine or taurine.
  • Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates.
  • Formerly EC 6.2.1.29.
Cross-references
BRENDA6.2.1.7
EC2PDB6.2.1.7
ExplorEnz6.2.1.7
PRIAM enzyme-specific profiles6.2.1.7
KEGG Ligand Database for Enzyme Nomenclature6.2.1.7
IUBMB Enzyme Nomenclature6.2.1.7
IntEnz6.2.1.7
MEDLINEFind literature relating to 6.2.1.7
MetaCyc6.2.1.7
UniProtKB/Swiss-Prot
Q9Y2P5, S27A5_HUMAN;  Q4LDG0, S27A5_MOUSE;  Q9ES38, S27A5_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-