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ENZYME entry: EC

Accepted Name
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase.
Alternative Name(s)
MurF synthetase.
UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase.
UDP-MurNAc-pentapeptide synthetase.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D- alanyl-D-alanine synthetase.
UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase.
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D- alanine ligase.
UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase.
UDPacetylmuramoylpentapeptide synthetase.
Uridine diphosphoacetylmuramoylpentapeptide synthetase.
Reaction catalysed
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine <=> ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
  • Involved with EC, EC or EC, EC and EC in the synthesis of a cell-wall peptide.
  • Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2,4-diaminoheptanedioate (acylated at its L-center), linking the D-Ala--D-Ala to the carboxy group of the L-center.
  • Formerly EC
PRIAM enzyme-specific profiles6.3.2.10
KEGG Ligand Database for Enzyme Nomenclature6.3.2.10
IUBMB Enzyme Nomenclature6.3.2.10
MEDLINEFind literature relating to
P96613, MURF_BACSU;  Q44777, MURF_BORBU;  P57315, MURF_BUCAI;  
O05953, MURF_RICPR;  O33804, MURF_STRTO;  P45450, MURF_SYNY3;  
O83401, MURF_TREPA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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