ENZYME entry: EC 6.3.2.10

Accepted Name
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase.
Alternative Name(s)
MurF synthetase.
UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase.
UDP-MurNAc-pentapeptide synthetase.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D- alanyl-D-alanine synthetase.
UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase.
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D- alanine ligase.
UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase.
UDPacetylmuramoylpentapeptide synthetase.
Uridine diphosphoacetylmuramoylpentapeptide synthetase.
Reaction catalysed
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine <=> ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
Comment(s)
  • Involved with EC 6.3.2.4, EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8 and EC 6.3.2.9 in the synthesis of a cell-wall peptide.
  • Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2,4-diaminoheptanedioate (acylated at its L-center), linking the D-Ala--D-Ala to the carboxy group of the L-center.
  • Formerly EC 6.3.2.15.
Cross-references
BRENDA6.3.2.10
EC2PDB6.3.2.10
ExplorEnz6.3.2.10
PRIAM enzyme-specific profiles6.3.2.10
KEGG Ligand Database for Enzyme Nomenclature6.3.2.10
IUBMB Enzyme Nomenclature6.3.2.10
IntEnz6.3.2.10
MEDLINEFind literature relating to 6.3.2.10
MetaCyc6.3.2.10
UniProtKB/Swiss-Prot
P96613, MURF_BACSU;  Q44777, MURF_BORBU;  P57315, MURF_BUCAI;  
Q89AQ1, MURF_BUCBP;  P11880, MURF_ECOLI;  P45061, MURF_HAEIN;  
P0A5L5, MURF_MYCBO;  O69556, MURF_MYCLE;  P9WJL0, MURF_MYCTO;  
P9WJL1, MURF_MYCTU;  Q92H60, MURF_RICCN;  Q9AKP1, MURF_RICMO;  
O05953, MURF_RICPR;  O33804, MURF_STRTO;  P45450, MURF_SYNY3;  
O83401, MURF_TREPA;  

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