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ENZYME entry: EC

Accepted Name
Carnosine synthase.
Alternative Name(s)
Carnosine synthetase.
Reaction catalysed
ATP + L-histidine + beta-alanine <=> ADP + phosphate + carnosine
  • This enzyme was thought to form AMP, but studies with highly purified enzyme proved that it forms ADP.
  • Carnosine is a dipeptide that is present at high concentrations in skeletal muscle and the olfactory bulb of vertebrates.
  • It is also found in the skeletal muscle of some invertebrates.
  • The enzyme can also catalyze the formation of homocarnosine from 4-aminobutyrate and L-histidine, with much lower activity.
PRIAM enzyme-specific profiles6.3.2.11
KEGG Ligand Database for Enzyme Nomenclature6.3.2.11
IUBMB Enzyme Nomenclature6.3.2.11
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