ENZYME entry: EC 6.3.2.19

Accepted Name
Ubiquitin--protein ligase.
Alternative Name(s)
Ubiquitin-activating enzyme.
Ubiquitin-conjugating enzyme.
Reaction catalysed
ATP + ubiquitin + protein lysine <=> AMP + diphosphate + protein N-ubiquityllysine
Comment(s)
  • Ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein.
  • An intermediate in the reaction contains one ubiquitin residue bound as a thioester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme.
Cross-references
PROSITEPDOC00163
BRENDA6.3.2.19
EC2PDB6.3.2.19
ExplorEnz6.3.2.19
PRIAM enzyme-specific profiles6.3.2.19
KEGG Ligand Database for Enzyme Nomenclature6.3.2.19
IUBMB Enzyme Nomenclature6.3.2.19
IntEnz6.3.2.19
MEDLINEFind literature relating to 6.3.2.19
MetaCyc6.3.2.19
UniProtKB/Swiss-Prot
Q8LGF7, PEX4_ARATH;  Q14258, TRI25_HUMAN;  Q61510, TRI25_MOUSE;  
Q6ZWY6, U2D2B_MOUSE;  P70711, U2D2B_RAT;  Q9VM35, U2QL1_DROME;  
A1L167, U2QL1_HUMAN;  A0PJN4, U2QL1_MOUSE;  Q2TA10, UB2D1_BOVIN;  
P51668, UB2D1_HUMAN;  P61080, UB2D1_MOUSE;  D3ZDK2, UB2D1_RAT;  
Q1RMX2, UB2D2_BOVIN;  P62837, UB2D2_HUMAN;  P62838, UB2D2_MOUSE;  
Q06AA9, UB2D2_PIG;  P62839, UB2D2_RAT;  P62840, UB2D2_XENLA;  
Q3ZCF7, UB2D3_BOVIN;  P61077, UB2D3_HUMAN;  Q4R5N4, UB2D3_MACFA;  
P61079, UB2D3_MOUSE;  Q5R4V7, UB2D3_PONAB;  P61078, UB2D3_RAT;  
Q9Y2X8, UB2D4_HUMAN;  A5PKP9, UB2D4_XENLA;  P51965, UB2E1_HUMAN;  
P52482, UB2E1_MOUSE;  Q96LR5, UB2E2_HUMAN;  Q91W82, UB2E2_MOUSE;  
Q2T9X7, UB2E3_BOVIN;  Q969T4, UB2E3_HUMAN;  P52483, UB2E3_MOUSE;  
P62253, UB2G1_HUMAN;  Q4R5Y8, UB2G1_MACFA;  P62254, UB2G1_MOUSE;  
P62255, UB2G1_RAT;  Q17QG5, UB2G2_BOVIN;  P60604, UB2G2_HUMAN;  
P60605, UB2G2_MOUSE;  Q5RF84, UB2G2_PONAB;  Q9Y385, UB2J1_HUMAN;  
Q9JJZ4, UB2J1_MOUSE;  Q2TA03, UB2J2_BOVIN;  Q54LP7, UB2J2_DICDI;  
Q8N2K1, UB2J2_HUMAN;  Q6P073, UB2J2_MOUSE;  Q54AK6, UB2JL_DICDI;  
Q3MHP1, UB2L3_BOVIN;  P68036, UB2L3_HUMAN;  P68037, UB2L3_MOUSE;  
Q5R5I4, UB2L3_PONAB;  A5PJC4, UB2L6_BOVIN;  O14933, UB2L6_HUMAN;  
Q9QZU9, UB2L6_MOUSE;  Q4V8J2, UB2L6_RAT;  Q7Z7E8, UB2Q1_HUMAN;  
Q7TSS2, UB2Q1_MOUSE;  Q32L27, UB2Q2_BOVIN;  Q8WVN8, UB2Q2_HUMAN;  
Q8K2Z8, UB2Q2_MOUSE;  Q7YQJ9, UB2Q2_RABIT;  P49427, UB2R1_HUMAN;  
Q8CFI2, UB2R1_MOUSE;  Q712K3, UB2R2_HUMAN;  Q6ZWZ2, UB2R2_MOUSE;  
Q29503, UB2R2_RABIT;  A1L3K1, UB2SA_XENLA;  Q8AVU2, UB2SB_XENLA;  
Q76EZ2, UB2SC_XENLA;  Q4VBH4, UB2WA_DANRE;  Q1JPX4, UB2WB_DANRE;  
P35133, UBC10_ARATH;  P35134, UBC11_ARATH;  O00103, UBC11_SCHPO;  
P52492, UBC11_YEAST;  Q9C9Y7, UBC12_ARATH;  Q42541, UBC13_ARATH;  
O13685, UBC13_SCHPO;  P52490, UBC13_YEAST;  P42747, UBC14_ARATH;  
Q9UTN8, UBC14_SCHPO;  P42743, UBC15_ARATH;  Q9Y818, UBC15_SCHPO;  
Q9FWT2, UBC16_ARATH;  Q9P6I1, UBC16_SCHPO;  O23239, UBC17_ARATH;  
Q9FMM0, UBC18_ARATH;  Q9LJZ5, UBC19_ARATH;  P25865, UBC1_ARATH;  
P52478, UBC1_CAEEL;  O74196, UBC1_COLGL;  Q9UVR2, UBC1_MAGO7;  
Q5UQC9, UBC1_MIMIV;  O74810, UBC1_SCHPO;  P21734, UBC1_YEAST;  
Q8L7T3, UBC20_ARATH;  P52484, UBC21_CAEEL;  Q9FF66, UBC22_ARATH;  
Q9ZVX1, UBC23_ARATH;  Q8VY10, UBC24_ARATH;  Q9LUQ5, UBC25_ARATH;  
Q8GY87, UBC26_ARATH;  Q9FI61, UBC27_ARATH;  Q94F47, UBC28_ARATH;  
Q9SLE4, UBC29_ARATH;  P42745, UBC2_ARATH;  Q75EB8, UBC2_ASHGO;  
Q4WLA7, UBC2_ASPFU;  P35129, UBC2_CAEEL;  O74201, UBC2_CANAL;  
Q6FR76, UBC2_CANGA;  P0CS17, UBC2_CRYNB;  P0CS16, UBC2_CRYNJ;  
Q6BU36, UBC2_DEBHA;  Q553F3, UBC2_DICDI;  Q96UP5, UBC2_EMENI;  
Q6CUD9, UBC2_KLULA;  P35130, UBC2_MEDSA;  Q5UQ57, UBC2_MIMIV;  
P78717, UBC2_NECHA;  P52493, UBC2_NEUCR;  P23566, UBC2_SCHPO;  
Q58FS2, UBC2_TRIHA;  Q4PFA5, UBC2_USTMA;  P25866, UBC2_WHEAT;  
Q6C093, UBC2_YARLI;  P06104, UBC2_YEAST;  Q9FKT3, UBC30_ARATH;  
Q9C8X7, UBC31_ARATH;  Q9LSP7, UBC32_ARATH;  Q9FK29, UBC33_ARATH;  
Q9SHI7, UBC34_ARATH;  Q94A97, UBC35_ARATH;  Q9FZ48, UBC36_ARATH;  
Q941B6, UBC37_ARATH;  P42746, UBC3_ARATH;  Q5UQ88, UBC3_MIMIV;  
P14682, UBC3_YEAST;  P42748, UBC4_ARATH;  P43102, UBC4_CANAX;  
Q5UQ40, UBC4_MIMIV;  P46595, UBC4_SCHPO;  P35135, UBC4_SOLLC;  
P16577, UBC4_WHEAT;  P15731, UBC4_YEAST;  Q8S920, UBC5A_ORYSJ;  
Q8S919, UBC5B_ORYSJ;  P42749, UBC5_ARATH;  P15732, UBC5_YEAST;  
P42750, UBC6_ARATH;  Q74Z34, UBC6_ASHGO;  Q6FQK7, UBC6_CANGA;  
Q6BYG4, UBC6_DEBHA;  Q6CMG6, UBC6_KLULA;  O42646, UBC6_SCHPO;  
P33296, UBC6_YEAST;  Q42540, UBC7_ARATH;  P34477, UBC7_CAEEL;  
O00102, UBC7_SCHPO;  P25868, UBC7_WHEAT;  Q02159, UBC7_YEAST;  
P52487, UBC84_DROME;  P35131, UBC8_ARATH;  Q9P7R4, UBC8_SCHPO;  
P28263, UBC8_YEAST;  Q94490, UBCB_DICDI;  P25867, UBCD1_DROME;  
P52485, UBCD2_DROME;  P52486, UBCD4_DROME;  P25153, UBCD6_DROME;  
Q86IZ3, UBCX_DICDI;  O60015, UBCX_PICAN;  P49428, UBCX_PICPA;  
P29340, UBCX_YEAST;  P27949, UBC_ASFB7;  P0C8G3, UBC_ASFK5;  
P25869, UBC_ASFM2;  P0C8G4, UBC_ASFP4;  P0C8G5, UBC_ASFWA;  
P49459, UBE2A_HUMAN;  Q9Z255, UBE2A_MOUSE;  Q32P99, UBE2B_BOVIN;  
P63146, UBE2B_HUMAN;  P63147, UBE2B_MOUSE;  P63148, UBE2B_RABIT;  
P63149, UBE2B_RAT;  Q32PA5, UBE2C_BOVIN;  Q54XS6, UBE2C_DICDI;  
Q9VTY6, UBE2C_DROME;  O00762, UBE2C_HUMAN;  Q4R9D1, UBE2C_MACFA;  
Q9D1C1, UBE2C_MOUSE;  Q95044, UBE2C_SPISO;  P56616, UBE2C_XENLA;  
Q32LN1, UBE2H_BOVIN;  P62256, UBE2H_HUMAN;  P62257, UBE2H_MOUSE;  
P61085, UBE2K_BOVIN;  P61086, UBE2K_HUMAN;  P61087, UBE2K_MOUSE;  
Q0P5K3, UBE2N_BOVIN;  Q86K32, UBE2N_DICDI;  P35128, UBE2N_DROME;  
P61088, UBE2N_HUMAN;  Q4R4I1, UBE2N_MACFA;  P61089, UBE2N_MOUSE;  
Q5R7J6, UBE2N_PONAB;  Q9EQX9, UBE2N_RAT;  Q9C0C9, UBE2O_HUMAN;  
Q6ZPJ3, UBE2O_MOUSE;  Q1RML1, UBE2S_BOVIN;  C3Z724, UBE2S_BRAFL;  
Q4V908, UBE2S_DANRE;  Q54I43, UBE2S_DICDI;  B3MQV3, UBE2S_DROAN;  
B3NWW9, UBE2S_DROER;  B4JKB7, UBE2S_DROGR;  Q9VX25, UBE2S_DROME;  
B4L7V4, UBE2S_DROMO;  B4H9W2, UBE2S_DROPE;  B5DKM4, UBE2S_DROPS;  
B4IF39, UBE2S_DROSE;  B4R6G1, UBE2S_DROSI;  B4MA02, UBE2S_DROVI;  
B4N208, UBE2S_DROWI;  B4Q2J2, UBE2S_DROYA;  Q16763, UBE2S_HUMAN;  
C1C3R6, UBE2S_LITCT;  Q921J4, UBE2S_MOUSE;  A7SE05, UBE2S_NEMVE;  
B5DFI8, UBE2S_RAT;  Q28F89, UBE2S_XENTR;  Q32LD2, UBE2T_BOVIN;  
Q08BH7, UBE2T_DANRE;  Q9NPD8, UBE2T_HUMAN;  Q9CQ37, UBE2T_MOUSE;  
Q7ZY08, UBE2T_XENLA;  Q5VVX9, UBE2U_HUMAN;  Q95LM1, UBE2U_MACFA;  
A6H795, UBE2W_BOVIN;  Q55EY8, UBE2W_DICDI;  Q96B02, UBE2W_HUMAN;  
Q8VDW4, UBE2W_MOUSE;  B5DEI4, UBE2W_RAT;  Q28FC1, UBE2W_XENTR;  
Q6DG60, UBE2Z_DANRE;  Q9H832, UBE2Z_HUMAN;  Q3UE37, UBE2Z_MOUSE;  
Q3B7D1, UBE2Z_RAT;  Q6PCF7, UBE2Z_XENLA;  Q66KB0, UBE2Z_XENTR;  
Q8SSK3, Y1A1_ENCCU;  

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