ENZYME entry: EC 6.3.4.18

Accepted Name
5-(carboxyamino)imidazole ribonucleotide synthase.
Alternative Name(s)
N(5)-CAIR synthetase.
N(5)-carboxyaminoimidazole ribonucleotide synthetase.
Reaction catalysed
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) <=> ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
Comment(s)
  • In Escherichia coli, this enzyme, along with EC 5.4.99.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates.
  • Carboxyphosphate is the putative acyl phosphate intermediate.
  • Involved in the late stages of purine biosynthesis.
Cross-references
BRENDA6.3.4.18
EC2PDB6.3.4.18
ExplorEnz6.3.4.18
PRIAM enzyme-specific profiles6.3.4.18
KEGG Ligand Database for Enzyme Nomenclature6.3.4.18
IUBMB Enzyme Nomenclature6.3.4.18
IntEnz6.3.4.18
MEDLINEFind literature relating to 6.3.4.18
MetaCyc6.3.4.18
UniProtKB/Swiss-Prot
O66608, PURK_AQUAE;  P12045, PURK_BACSU;  P52559, PURK_BRUME;  
Q44678, PURK_CORAM;  P09029, PURK_ECOLI;  P43850, PURK_HAEIN;  
P65899, PURK_MYCBO;  P46701, PURK_MYCLE;  P65898, PURK_MYCTU;  
P72158, PURK_PSEAE;  Q5HH19, PURK_STAAC;  Q99V32, PURK_STAAM;  
Q7A695, PURK_STAAN;  Q6GI19, PURK_STAAR;  Q6GAE8, PURK_STAAS;  
Q8NX94, PURK_STAAW;  Q5HQA5, PURK_STAEQ;  Q8CPP2, PURK_STAES;  
Q4L574, PURK_STAHJ;  Q49WI9, PURK_STAS1;  O06457, PURK_SULSO;  
Q54975, PURK_SYNE7;  P74724, PURK_SYNY3;  Q9KVT8, PURK_VIBCH;  
Q5E1R3, PURK_VIBF1;  Q87KE0, PURK_VIBPA;  Q8DDD8, PURK_VIBVU;  
Q7MGL1, PURK_VIBVY;  

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