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ENZYME

ENZYME entry: EC 2.7.11.21

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.21
Accepted Name
polo kinase
Alternative Name(s)
PLK
polo-like kinase
polo serine-threonine kinase
Reaction catalysed
  • L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)
  • L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)
Comment(s)
  • The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation.
  • The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.11.21
EC2PDB2.7.11.21
ExplorEnz2.7.11.21
KEGG Ligand Database for Enzyme Nomenclature2.7.11.21
IUBMB Enzyme Nomenclature2.7.11.21
MEDLINEFind literature relating to 2.7.11.21
MetaCyc2.7.11.21
Rhea expert-curated reactions2.7.11.21
UniProtKB/Swiss-Prot
P0C8M8, CCR1_MAIZEQ8SWM6, CDC5_ENCCUP32562, CDC5_YEAST
Q2TA25, PLK1_BOVINP34331, PLK1_CAEELP53350, PLK1_HUMAN
Q07832, PLK1_MOUSEQ62673, PLK1_RATP70032, PLK1_XENLA
P62205, PLK1_XENTRQ9N2L7, PLK2_CAEELQ9NYY3, PLK2_HUMAN
P53351, PLK2_MOUSEQ5R4L1, PLK2_PONABQ9R012, PLK2_RAT
Q20845, PLK3_CAEELQ9H4B4, PLK3_HUMANQ60806, PLK3_MOUSE
Q9R011, PLK3_RATQ16W24, PLK4_AEDAEA2VDZ4, PLK4_BOVIN
B0WAU8, PLK4_CULQUQ7ZVS3, PLK4_DANREB3M6I4, PLK4_DROAN
B3NE99, PLK4_DROERB4J3F1, PLK4_DROGRO97143, PLK4_DROME
B4KYX8, PLK4_DROMOB4HBU3, PLK4_DROPEQ2LYK3, PLK4_DROPS
B4IAQ8, PLK4_DROSEB4QK53, PLK4_DROSIB4LDJ6, PLK4_DROVI
B4MXR8, PLK4_DROWIB4PDM5, PLK4_DROYAO00444, PLK4_HUMAN
Q64702, PLK4_MOUSEA7SNN5, PLK4_NEMVEQ5R9Z7, PLK4_PONAB
B2GUY1, PLK4_RATQ6PAD2, PLK4_XENLAB3DL84, PLK4_XENTR
A8BPK8, PLK_GIAICP50528, PLO1_SCHPOP52304, POLO_DROME

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