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ENZYME entry: EC 1.1.1.105

Accepted Name
All-trans-retinol dehydrogenase (NAD(+)).
Reaction catalysed
All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) <=> all-trans-retinal-[cellular-retinol-binding-protein] + NADH
Comment(s)
  • The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors.
  • Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
  • No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315).
  • Also active with 3-alpha-hydroxysteroids.
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.105
EC2PDB1.1.1.105
ExplorEnz1.1.1.105
PRIAM enzyme-specific profiles1.1.1.105
KEGG Ligand Database for Enzyme Nomenclature1.1.1.105
IUBMB Enzyme Nomenclature1.1.1.105
IntEnz1.1.1.105
MEDLINEFind literature relating to 1.1.1.105
MetaCyc1.1.1.105
Rhea expert-curated reactions1.1.1.105
UniProtKB/Swiss-Prot
P00325, ADH1B_HUMAN;  Q5R1W2, ADH1B_PANTR;  P14139, ADH1B_PAPHA;  
P08319, ADH4_HUMAN;  Q9QYY9, ADH4_MOUSE;  Q64563, ADH4_RAT;  
P80468, ADH4_STRCA;  P40394, ADH7_HUMAN;  Q64437, ADH7_MOUSE;  
P41682, ADH7_RAT;  Q8HYR6, DHRS9_BOVIN;  Q9BPW9, DHRS9_HUMAN;  
Q58NB6, DHRS9_MOUSE;  Q8VD48, DHRS9_RAT;  Q1RMJ5, DRS7C_BOVIN;  
A6NNS2, DRS7C_HUMAN;  Q8CHS7, DRS7C_MOUSE;  D3ZGP9, DRS7C_RAT;  
Q3T001, H17B6_BOVIN;  O14756, H17B6_HUMAN;  Q9R092, H17B6_MOUSE;  
O54753, H17B6_RAT;  O75452, RDH16_HUMAN;  O54909, RDH16_MOUSE;  
P50170, RDH16_RAT;  O88451, RDH7_MOUSE;  P55006, RDH7_RAT;  
Q8N3Y7, RDHE2_HUMAN;  Q7TQA3, RDHE2_MOUSE;  

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