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ENZYME

ENZYME entry: EC 1.1.1.105

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.105
Accepted Name
all-trans-retinol dehydrogenase (NAD(+))
Reaction catalysed
all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + NADH + H(+)
Comment(s)
  • The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors.
  • Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
  • No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315).
  • Also active with 3alpha-hydroxysteroids.
Cross-references
BRENDA1.1.1.105
EC2PDB1.1.1.105
ExplorEnz1.1.1.105
KEGG Ligand Database for Enzyme Nomenclature1.1.1.105
IUBMB Enzyme Nomenclature1.1.1.105
MEDLINEFind literature relating to 1.1.1.105
MetaCyc1.1.1.105
Rhea expert-curated reactions1.1.1.105
UniProtKB/Swiss-Prot
P00325, ADH1B_HUMANQ5R1W2, ADH1B_PANTRP14139, ADH1B_PAPHA
P08319, ADH4_HUMANQ9QYY9, ADH4_MOUSEQ64563, ADH4_RAT
P80468, ADH4_STRCAP40394, ADH7_HUMANQ64437, ADH7_MOUSE
P41682, ADH7_RATQ7Z5P4, DHB13_HUMANQ8VCR2, DHB13_MOUSE
Q5M875, DHB13_RATQ8HYR6, DHRS9_BOVINQ9BPW9, DHRS9_HUMAN
Q58NB6, DHRS9_MOUSEQ8VD48, DHRS9_RATQ1RMJ5, DRS7C_BOVIN
A6NNS2, DRS7C_HUMANQ8CHS7, DRS7C_MOUSED3ZGP9, DRS7C_RAT
Q3T001, H17B6_BOVINO14756, H17B6_HUMANQ9R092, H17B6_MOUSE
O54753, H17B6_RATO75452, RDH16_HUMANO54909, RDH16_MOUSE
P50170, RDH16_RATO88451, RDH7_MOUSEP55006, RDH7_RAT
Q8N3Y7, RDHE2_HUMANQ7TQA3, RDHE2_MOUSE

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