ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.1.1.110

Accepted Name
Aromatic 2-oxoacid reductase.
Alternative Name(s)
(R)-4-hydroxyphenyllactate dehydrogenase.
(R)-aromatic lactate dehydrogenase.
Indole-3-lactate dehydrogenase.
Indolelactate dehydrogenase.
Reaction catalysed
(R)-3-(phenyl)lactate + NAD(+) <=> 3-phenyl-2-oxopropanoate + NADH (R)-3-(4-hydroxyphenyl)lactate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + NADH (Indol-3-yl)lactate + NAD(+) <=> (indol-3-yl)pyruvate + NADH
Comment(s)
The enzymes from anaerobic bacteria such as Clostridium sporogenes participate in the fermentation pathways of L-phenylalanine, L-tyrosine and L-tryptophan. The enzyme from the yeast Candida maltosa has similar activity, but, unlike the bacterial enzyme, requires Mn(2+) and can also use NADPH with lower activity. Formerly EC 1.1.1.222.
Cross-references
BRENDA	1.1.1.110
EC2PDB	1.1.1.110
ExplorEnz	1.1.1.110
PRIAM enzyme-specific profiles	1.1.1.110
KEGG Ligand Database for Enzyme Nomenclature	1.1.1.110
IUBMB Enzyme Nomenclature	1.1.1.110
IntEnz	1.1.1.110
MEDLINE	Find literature relating to 1.1.1.110
MetaCyc	1.1.1.110