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ENZYME entry: EC 1.1.1.110

Accepted Name
aromatic 2-oxoacid reductase.
Alternative Name(s)
(R)-4-hydroxyphenyllactate dehydrogenase.
(R)-aromatic lactate dehydrogenase.
indole-3-lactate dehydrogenase.
indolelactate dehydrogenase.
Reaction catalysed
  • (R)-3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH
  • (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH
  • 3-(indol-3-yl)lactate + NAD(+) <=> H(+) + indole-3-pyruvate + NADH
Comment(s)
  • The enzymes from anaerobic bacteria such as Clostridium sporogenes participate in the fermentation pathways of L-phenylalanine, L-tyrosine and L-tryptophan.
  • The enzyme from the yeast Candida maltosa has similar activity, but, unlike the bacterial enzyme, requires Mn(2+) and can also use NADPH with lower activity.
  • Formerly EC 1.1.1.222.
Cross-references
BRENDA1.1.1.110
EC2PDB1.1.1.110
ExplorEnz1.1.1.110
PRIAM enzyme-specific profiles1.1.1.110
KEGG Ligand Database for Enzyme Nomenclature1.1.1.110
IUBMB Enzyme Nomenclature1.1.1.110
IntEnz1.1.1.110
MEDLINEFind literature relating to 1.1.1.110
MetaCyc1.1.1.110
Rhea expert-curated reactions1.1.1.110
UniProtKB/Swiss-Prot
J7SHB8, FLDH_CLOS1;  G9EZR6, FLDH_CLOS3;  

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