ENZYME entry: EC 1.1.1.153
Accepted Name |
Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
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Reaction catalysed |
- L-erythro-7,8-dihydrobiopterin + NADP(+) <=> sepiapterin + NADPH
- L-erythro-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH
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Comment(s) |
- This enzyme catalyzes the final step in the de novo synthesis of
tetrahydrobiopterin from GTP.
- The enzyme, which is found in higher animals and some fungi and
bacteria, produces the erythro form of tetrahydrobiopterin.
- Cf. EC 1.1.1.325.
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Cross-references |
BRENDA | 1.1.1.153 |
EC2PDB | 1.1.1.153 |
ExplorEnz | 1.1.1.153 |
PRIAM enzyme-specific profiles | 1.1.1.153 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.153 |
IUBMB Enzyme Nomenclature | 1.1.1.153 |
IntEnz | 1.1.1.153 |
MEDLINE | Find literature relating to 1.1.1.153 |
MetaCyc | 1.1.1.153 |
UniProtKB/Swiss-Prot |
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