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ENZYME entry: EC 1.1.1.153

Accepted Name
Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
Reaction catalysed
  • L-erythro-7,8-dihydrobiopterin + NADP(+) <=> sepiapterin + NADPH
  • L-erythro-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH
Comment(s)
  • This enzyme catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP.
  • The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin.
  • Cf. EC 1.1.1.325.
Cross-references
BRENDA1.1.1.153
EC2PDB1.1.1.153
ExplorEnz1.1.1.153
PRIAM enzyme-specific profiles1.1.1.153
KEGG Ligand Database for Enzyme Nomenclature1.1.1.153
IUBMB Enzyme Nomenclature1.1.1.153
IntEnz1.1.1.153
MEDLINEFind literature relating to 1.1.1.153
MetaCyc1.1.1.153
Rhea expert-curated reactions1.1.1.153
UniProtKB/Swiss-Prot
Q17QK8, SPRE_BOVIN;  Q54GP3, SPRE_DICDI;  P35270, SPRE_HUMAN;  
Q8R536, SPRE_MERUN;  Q64105, SPRE_MOUSE;  P18297, SPRE_RAT;  
Q7ZY31, SPRE_XENLA;  B0BML7, SPRE_XENTR;  

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