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ENZYME entry: EC 1.1.1.325

Accepted Name
sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming).
Reaction catalysed
  • L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin
  • L-threo-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
Comment(s)
  • This enzyme, isolated from the bacterium Chlorobium tepidum, catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP.
  • Cf. EC 1.1.1.153.
Cross-references
BRENDA1.1.1.325
EC2PDB1.1.1.325
ExplorEnz1.1.1.325
PRIAM enzyme-specific profiles1.1.1.325
KEGG Ligand Database for Enzyme Nomenclature1.1.1.325
IUBMB Enzyme Nomenclature1.1.1.325
IntEnz1.1.1.325
MEDLINEFind literature relating to 1.1.1.325
MetaCyc1.1.1.325
Rhea expert-curated reactions1.1.1.325
UniProtKB/Swiss-Prot
Q8KES3, SPRE_CHLTE

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