ENZYME entry: EC 1.1.1.325

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.325

Accepted Name

sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)

Reaction catalysed

L-threo-7,8-dihydrobiopterin + NADP(+) = L-sepiapterin + NADPH + H(+)
L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H(+)

Comment(s)

This enzyme, isolated from the bacterium Chlorobium tepidum, catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP. cf. EC 1.1.1.153.

Cross-references

BRENDA

1.1.1.325

EC2PDB

1.1.1.325

ExplorEnz

1.1.1.325

KEGG Ligand Database for Enzyme Nomenclature

1.1.1.325

IUBMB Enzyme Nomenclature

1.1.1.325

MEDLINE

Find literature relating to 1.1.1.325

MetaCyc

1.1.1.325

Rhea expert-curated reactions

1.1.1.325

UniProtKB/Swiss-Prot

Q8KES3, SPRE_CHLTE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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