ENZYME entry: EC 1.1.1.184
Accepted Name |
carbonyl reductase (NADPH).
|
Alternative Name(s) |
aldehyde reductase I. |
NADPH-dependent carbonyl reductase. |
prostaglandin 9-ketoreductase. |
xenobiotic ketone reductase. |
Reaction catalysed |
a secondary alcohol + NADP(+) <=> a ketone + H(+) + NADPH |
Comment(s) |
- Acts on a wide range of carbonyl compounds, including quinones,
aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins
E and F, reducing them to the corresponding alcohol.
- Si-specific with respect to NADPH (cf. EC 1.1.1.2).
|
Cross-references |
BRENDA | 1.1.1.184 |
EC2PDB | 1.1.1.184 |
ExplorEnz | 1.1.1.184 |
PRIAM enzyme-specific profiles | 1.1.1.184 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.184 |
IUBMB Enzyme Nomenclature | 1.1.1.184 |
IntEnz | 1.1.1.184 |
MEDLINE | Find literature relating to 1.1.1.184 |
MetaCyc | 1.1.1.184 |
Rhea expert-curated reactions | 1.1.1.184 |
UniProtKB/Swiss-Prot |
P74308, AKR_SYNY3; | Q3SZD7, CBR1_BOVIN; | P16152, CBR1_HUMAN; |
Q8MI29, CBR1_MACFA; | P48758, CBR1_MOUSE; | Q28960, CBR1_PIG; |
Q5RCU5, CBR1_PONAB; | P47844, CBR1_RABIT; | P47727, CBR1_RAT; |
P08074, CBR2_MOUSE; | Q29529, CBR2_PIG; | O75828, CBR3_HUMAN; |
Q8K354, CBR3_MOUSE; | B2GV72, CRB3_RAT; | Q8SPU8, DHRS4_BOVIN; |
G5EGA6, DHRS4_CAEEL; | Q9BTZ2, DHRS4_HUMAN; | Q99LB2, DHRS4_MOUSE; |
Q8WNV7, DHRS4_PIG; | Q5RCF8, DHRS4_PONAB; | Q9GKX2, DHRS4_RABIT; |
Q8VID1, DHRS4_RAT; |
|
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UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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