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ENZYME entry: EC 1.1.1.184

Accepted Name
Carbonyl reductase (NADPH).
Alternative Name(s)
Aldehyde reductase I.
NADPH-dependent carbonyl reductase.
Prostaglandin 9-ketoreductase.
Xenobiotic ketone reductase.
Reaction catalysed
R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH
Comment(s)
  • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
  • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.184
EC2PDB1.1.1.184
ExplorEnz1.1.1.184
PRIAM enzyme-specific profiles1.1.1.184
KEGG Ligand Database for Enzyme Nomenclature1.1.1.184
IUBMB Enzyme Nomenclature1.1.1.184
IntEnz1.1.1.184
MEDLINEFind literature relating to 1.1.1.184
MetaCyc1.1.1.184
Rhea expert-curated reactions1.1.1.184
UniProtKB/Swiss-Prot
P74308, AKR_SYNY3;  Q3SZD7, CBR1_BOVIN;  P16152, CBR1_HUMAN;  
Q8MI29, CBR1_MACFA;  P48758, CBR1_MOUSE;  Q28960, CBR1_PIG;  
Q5RCU5, CBR1_PONAB;  P47844, CBR1_RABIT;  P47727, CBR1_RAT;  
P08074, CBR2_MOUSE;  Q29529, CBR2_PIG;  O75828, CBR3_HUMAN;  
Q8K354, CBR3_MOUSE;  Q8SPU8, DHRS4_BOVIN;  G5EGA6, DHRS4_CAEEL;  
Q9BTZ2, DHRS4_HUMAN;  Q99LB2, DHRS4_MOUSE;  Q8WNV7, DHRS4_PIG;  
Q5RCF8, DHRS4_PONAB;  Q9GKX2, DHRS4_RABIT;  Q8VID1, DHRS4_RAT;  

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