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ENZYME

ENZYME entry: EC 1.1.1.184

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.184
Accepted Name
carbonyl reductase (NADPH)
Alternative Name(s)
aldehyde reductase I
NADPH-dependent carbonyl reductase
prostaglandin 9-ketoreductase
xenobiotic ketone reductase
Reaction catalysed
a secondary alcohol + NADP(+) = a ketone + NADPH + H(+)
Comment(s)
  • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
  • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
Cross-references
BRENDA1.1.1.184
EC2PDB1.1.1.184
ExplorEnz1.1.1.184
KEGG Ligand Database for Enzyme Nomenclature1.1.1.184
IUBMB Enzyme Nomenclature1.1.1.184
MEDLINEFind literature relating to 1.1.1.184
MetaCyc1.1.1.184
Rhea expert-curated reactions1.1.1.184
UniProtKB/Swiss-Prot
P74308, AKR_SYNY3Q3SZD7, CBR1_BOVINP16152, CBR1_HUMAN
Q8MI29, CBR1_MACFAP48758, CBR1_MOUSEQ28960, CBR1_PIG
Q5RCU5, CBR1_PONABP47844, CBR1_RABITP47727, CBR1_RAT
P08074, CBR2_MOUSEQ29529, CBR2_PIGO75828, CBR3_HUMAN
Q8K354, CBR3_MOUSEB2GV72, CRB3_RATQ8SPU8, DHRS4_BOVIN
G5EGA6, DHRS4_CAEELQ9BTZ2, DHRS4_HUMANQ99LB2, DHRS4_MOUSE
Q8WNV7, DHRS4_PIGQ5RCF8, DHRS4_PONABQ9GKX2, DHRS4_RABIT
Q8VID1, DHRS4_RAT

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