A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.1.1.184
| Accepted Name |
|---|
| Carbonyl reductase (NADPH).
|
| Alternative Name(s) |
|---|
| Aldehyde reductase I. |
| NADPH-dependent carbonyl reductase. |
| Prostaglandin 9-ketoreductase. |
| Xenobiotic ketone reductase. |
| Reaction catalysed |
|---|
| R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH |
| Comment(s) |
|---|
- Acts on a wide range of carbonyl compounds, including quinones,
aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins
E and F, reducing them to the corresponding alcohol.
- Si-specific with respect to NADPH (cf. EC 1.1.1.2).
|
| Cross-references |
|---|
| PROSITE | PDOC00060 |
| BRENDA | 1.1.1.184 |
| EC2PDB | 1.1.1.184 |
| ExplorEnz | 1.1.1.184 |
| PRIAM enzyme-specific profiles | 1.1.1.184 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.184 |
| IUBMB Enzyme Nomenclature | 1.1.1.184 |
| IntEnz | 1.1.1.184 |
| MEDLINE | Find literature relating to 1.1.1.184 |
| MetaCyc | 1.1.1.184 |
| UniProtKB/Swiss-Prot |
| P74308, AKR_SYNY3; | Q3SZD7, CBR1_BOVIN; | P16152, CBR1_HUMAN; |
| Q8MI29, CBR1_MACFA; | P48758, CBR1_MOUSE; | Q28960, CBR1_PIG; |
| Q5RCU5, CBR1_PONAB; | P47844, CBR1_RABIT; | P47727, CBR1_RAT; |
| P08074, CBR2_MOUSE; | Q29529, CBR2_PIG; | O75828, CBR3_HUMAN; |
| Q8K354, CBR3_MOUSE; | Q8SPU8, DHRS4_BOVIN; | G5EGA6, DHRS4_CAEEL; |
| Q9BTZ2, DHRS4_HUMAN; | Q99LB2, DHRS4_MOUSE; | Q8WNV7, DHRS4_PIG; |
| Q5RCF8, DHRS4_PONAB; | Q9GKX2, DHRS4_RABIT; | Q8VID1, DHRS4_RAT; |
|
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