ENZYME entry: EC 1.1.1.218
Accepted Name |
Morphine 6-dehydrogenase.
|
Alternative Name(s) |
Naloxone reductase. |
Reaction catalysed |
Morphine + NAD(P)(+) <=> morphinone + NAD(P)H |
Comment(s) |
- Also acts on some other alkaloids, including codeine, normorphine and
ethylmorphine, but only very slowly on 7,8-saturated derivatives such
as dihydromorphine and dihydrocodeine.
- In the reverse direction, also reduces naloxone to the 6-alpha-
hydroxy analog.
- Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol).
|
Cross-references |
PROSITE | PDOC00061 |
BRENDA | 1.1.1.218 |
EC2PDB | 1.1.1.218 |
ExplorEnz | 1.1.1.218 |
PRIAM enzyme-specific profiles | 1.1.1.218 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.218 |
IUBMB Enzyme Nomenclature | 1.1.1.218 |
IntEnz | 1.1.1.218 |
MEDLINE | Find literature relating to 1.1.1.218 |
MetaCyc | 1.1.1.218 |
Rhea expert-curated reactions | 1.1.1.218 |
UniProtKB/Swiss-Prot |
|
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