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ENZYME entry: EC 1.1.1.218

Accepted Name
morphine 6-dehydrogenase.
Alternative Name(s)
naloxone reductase.
Reaction catalysed
  • morphine + NAD(+) <=> H(+) + morphinone + NADH
  • morphine + NADP(+) <=> H(+) + morphinone + NADPH
Comment(s)
  • Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine.
  • In the reverse direction, also reduces naloxone to the 6alpha-hydroxy analog.
  • Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol).
Cross-references
BRENDA1.1.1.218
EC2PDB1.1.1.218
ExplorEnz1.1.1.218
PRIAM enzyme-specific profiles1.1.1.218
KEGG Ligand Database for Enzyme Nomenclature1.1.1.218
IUBMB Enzyme Nomenclature1.1.1.218
IntEnz1.1.1.218
MEDLINEFind literature relating to 1.1.1.218
MetaCyc1.1.1.218
Rhea expert-curated reactions1.1.1.218
UniProtKB/Swiss-Prot
P82809, AK1CD_MESAU;  Q02198, MORA_PSEPU;  P82810, MORA_RABIT;  

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