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ENZYME

ENZYME entry: EC 1.1.1.239

Accepted Name
3alpha-(17beta)-hydroxysteroid dehydrogenase (NAD(+))
Alternative Name(s)
17beta-HSD
17-ketoreductase
Reaction catalysed
NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH
Comment(s)
  • Also acts on other 17beta-hydroxysteroids, on the 3alpha-hydroxy group of pregnanes and bile acids.
  • Different from EC 1.1.1.50 or EC 1.1.1.213.
  • Formerly EC 1.1.1.63.
Cross-references
BRENDA1.1.1.239
EC2PDB1.1.1.239
ExplorEnz1.1.1.239
PRIAM enzyme-specific profiles1.1.1.239
KEGG Ligand Database for Enzyme Nomenclature1.1.1.239
IUBMB Enzyme Nomenclature1.1.1.239
IntEnz1.1.1.239
MEDLINEFind literature relating to 1.1.1.239
MetaCyc1.1.1.239
Rhea expert-curated reactions1.1.1.239
UniProtKB/Swiss-Prot
P42330, AK1C3_HUMANQ5R7C9, AK1C3_PONABP37059, DHB2_HUMAN
P51658, DHB2_MOUSEQ62730, DHB2_RATQ9GME3, DHB8_CALJA
Q5TJF5, DHB8_CANLFQ92506, DHB8_HUMANP50171, DHB8_MOUSE
Q9XT00, DHB8_PIGQ6MGB5, DHB8_RATQ3T001, H17B6_BOVIN
O14756, H17B6_HUMANQ9R092, H17B6_MOUSEO54753, H17B6_RAT
O02691, HCD2_BOVINQ99714, HCD2_HUMANO08756, HCD2_MOUSE
O70351, HCD2_RAT

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