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ENZYME entry: EC 1.1.1.239

Accepted Name
3alpha-(17beta)-hydroxysteroid dehydrogenase (NAD(+)).
Alternative Name(s)
17beta-HSD.
17-ketoreductase.
Reaction catalysed
NAD(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADH
Comment(s)
  • Also acts on other 17beta-hydroxysteroids, on the 3alpha-hydroxy group of pregnanes and bile acids.
  • Different from EC 1.1.1.50 or EC 1.1.1.213.
  • Formerly EC 1.1.1.63.
Cross-references
BRENDA1.1.1.239
EC2PDB1.1.1.239
ExplorEnz1.1.1.239
PRIAM enzyme-specific profiles1.1.1.239
KEGG Ligand Database for Enzyme Nomenclature1.1.1.239
IUBMB Enzyme Nomenclature1.1.1.239
IntEnz1.1.1.239
MEDLINEFind literature relating to 1.1.1.239
MetaCyc1.1.1.239
Rhea expert-curated reactions1.1.1.239
UniProtKB/Swiss-Prot
P42330, AK1C3_HUMAN;  Q5R7C9, AK1C3_PONAB;  P37059, DHB2_HUMAN;  
P51658, DHB2_MOUSE;  Q62730, DHB2_RAT;  Q9GME3, DHB8_CALJA;  
Q5TJF5, DHB8_CANLF;  Q92506, DHB8_HUMAN;  P50171, DHB8_MOUSE;  
Q9XT00, DHB8_PIG;  Q6MGB5, DHB8_RAT;  Q3T001, H17B6_BOVIN;  
O14756, H17B6_HUMAN;  Q9R092, H17B6_MOUSE;  O54753, H17B6_RAT;  
O02691, HCD2_BOVIN;  Q99714, HCD2_HUMAN;  O08756, HCD2_MOUSE;  
O70351, HCD2_RAT;  

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