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ENZYME entry: EC 1.1.1.266

Accepted Name
dTDP-4-dehydro-6-deoxyglucose reductase.
Alternative Name(s)
dTDP-4-keto-6-deoxyglucose reductase.
Reaction catalysed
  • dTDP-alpha-D-fucose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH
  • dTDP-alpha-D-fucose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH
Comment(s)
  • The enzymes from the Gram-negative bacteria Actinobacillus actinomycetemcomitans and Escherichia coli O52 are involved in activation of fucose for incorporation into capsular polysaccharide O-antigens.
  • The enzyme from the Gram-positive bacterium Anoxybacillus tepidamans (Geobacillus tepidamans) is involved in activation of fucose for incorporation into the organism's S-layer.
  • The enzyme from E. coli O52 has a higher catalytic efficiency with NADH than with NADPH.
Cross-references
BRENDA1.1.1.266
EC2PDB1.1.1.266
ExplorEnz1.1.1.266
PRIAM enzyme-specific profiles1.1.1.266
KEGG Ligand Database for Enzyme Nomenclature1.1.1.266
IUBMB Enzyme Nomenclature1.1.1.266
IntEnz1.1.1.266
MEDLINEFind literature relating to 1.1.1.266
MetaCyc1.1.1.266
Rhea expert-curated reactions1.1.1.266
UniProtKB/Swiss-Prot
Q6E7F2, FCF1_ECOLX

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