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ENZYME

ENZYME entry: EC 1.1.1.282

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.282
Accepted Name
quinate/shikimate dehydrogenase [NAD(P)(+)]
Alternative Name(s)
quinate/shikimate dehydrogenase
Reaction catalysed
  • L-quinate + NADP(+) = 3-dehydroquinate + NADPH + H(+)
  • L-quinate + NAD(+) = 3-dehydroquinate + NADH + H(+)
  • shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)
  • shikimate + NAD(+) = 3-dehydroshikimate + NADH + H(+)
Comment(s)
  • This is the second shikimate dehydrogenase enzyme found in Escherichia coli.
  • It can use both quinate and shikimate as substrates and either NAD(+) or NADP(+) as acceptor.
  • The low catalytic efficiency with both quinate and shikimate suggests that neither may be the physiological substrate. cf. EC 1.1.1.24, EC 1.1.1.25, and EC 1.1.5.8.
Cross-references
BRENDA1.1.1.282
EC2PDB1.1.1.282
ExplorEnz1.1.1.282
KEGG Ligand Database for Enzyme Nomenclature1.1.1.282
IUBMB Enzyme Nomenclature1.1.1.282
MEDLINEFind literature relating to 1.1.1.282
MetaCyc1.1.1.282
Rhea expert-curated reactions1.1.1.282
UniProtKB/Swiss-Prot
A7ZMF7, YDIB_ECO24B7US31, YDIB_ECO27B7MAQ2, YDIB_ECO45
B7L5P4, YDIB_ECO55Q8X5Y4, YDIB_ECO57B5YPX9, YDIB_ECO5E
B7NTU4, YDIB_ECO7IB7MVG8, YDIB_ECO81B7M0P8, YDIB_ECO8A
C4ZYF4, YDIB_ECOBWB1XG00, YDIB_ECODHA8A0N8, YDIB_ECOHS
A1ABM9, YDIB_ECOK1Q0THD7, YDIB_ECOL5P0A6D6, YDIB_ECOL6
B1IQ64, YDIB_ECOLCP0A6D5, YDIB_ECOLIB7N528, YDIB_ECOLU
B6IBD2, YDIB_ECOSEB1LE44, YDIB_ECOSMQ1RBA4, YDIB_ECOUT
B5F7D6, YDIB_SALA4Q57PS7, YDIB_SALCHB5FJ81, YDIB_SALDC
B5QVU2, YDIB_SALEPB5RAU7, YDIB_SALG2B4TGJ7, YDIB_SALHS
B4T4Q4, YDIB_SALNSA9N158, YDIB_SALPBB4TUS3, YDIB_SALSV
Q8ZPR4, YDIB_SALTYB2U2J6, YDIB_SHIB3P0C2L9, YDIB_SHIBS
Q32GE1, YDIB_SHIDSQ0T479, YDIB_SHIF8Q83RA2, YDIB_SHIFL
Q3Z246, YDIB_SHISS

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