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ENZYME

ENZYME entry: EC 1.1.1.284

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.284
Accepted Name
S-(hydroxymethyl)glutathione dehydrogenase
Alternative Name(s)
ADH3
chi-ADH
class III alcohol dehydrogenase
FDH
formaldehyde dehydrogenase
formaldehyde dehydrogenase (glutathione)
formic dehydrogenase
GD-FALDH
glutathione-dependent formaldehyde dehydrogenase
GS-FDH
NAD- and glutathione-dependent formaldehyde dehydrogenase
NAD-dependent formaldehyde dehydrogenase
NAD-linked formaldehyde dehydrogenase
Reaction catalysed
  • S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)
  • S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)
Comment(s)
  • The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22.
  • Forms part of the pathway that detoxifies formaldehyde, since the product is hydrolyzed by EC 3.1.2.12.
  • Also specifically reduces S-nitrosylglutathione.
  • Formerly EC 1.2.1.1.
Cross-references
BRENDA1.1.1.284
EC2PDB1.1.1.284
ExplorEnz1.1.1.284
KEGG Ligand Database for Enzyme Nomenclature1.1.1.284
IUBMB Enzyme Nomenclature1.1.1.284
MEDLINEFind literature relating to 1.1.1.284
MetaCyc1.1.1.284
Rhea expert-curated reactions1.1.1.284
UniProtKB/Swiss-Prot
P81600, ADHH_GADMOP72324, ADHI_CERS4P81601, ADHL_GADMO
Q96533, ADHX_ARATHQ3ZC42, ADHX_BOVINQ17335, ADHX_CAEEL
Q54TC2, ADHX_DICDIP46415, ADHX_DROMEP19854, ADHX_HORSE
P11766, ADHX_HUMANP93629, ADHX_MAIZEP28474, ADHX_MOUSE
P80360, ADHX_MYXGLP81431, ADHX_OCTVUA2XAZ3, ADHX_ORYSI
Q0DWH1, ADHX_ORYSJP80572, ADHX_PEAO19053, ADHX_RABIT
P12711, ADHX_RATP80467, ADHX_SAAHAP86884, ADHX_SCYCA
P79896, ADHX_SPAAUP78870, FADH1_SCHPOO74540, FADH2_SCHPO
P0CL53, FADH_ASPORQ06099, FADH_CANMAP47734, FADH_METMR
P45382, FADH_PARDEO74685, FADH_PICPAP32771, FADH_YEAST
A7ZIA4, FRMA_ECO24Q8X5J4, FRMA_ECO57A7ZX04, FRMA_ECOHS
A1A835, FRMA_ECOK1Q0TKS7, FRMA_ECOL5Q8FKG1, FRMA_ECOL6
B1J085, FRMA_ECOLCP25437, FRMA_ECOLIB1LIP1, FRMA_ECOSM
Q1RFI7, FRMA_ECOUTP44557, FRMA_HAEINP39450, FRMA_PHODP
Q3Z550, FRMA_SHISSP73138, FRMA_SYNY3

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