| Accepted Name |
|---|
| S-(hydroxymethyl)glutathione dehydrogenase.
|
| Alternative Name(s) |
|---|
| ADH3. |
| chi-ADH. |
| class III alcohol dehydrogenase. |
| FDH. |
| formaldehyde dehydrogenase. |
| formaldehyde dehydrogenase (glutathione). |
| formic dehydrogenase. |
| GD-FALDH. |
| glutathione-dependent formaldehyde dehydrogenase. |
| GS-FDH. |
| NAD- and glutathione-dependent formaldehyde dehydrogenase. |
| NAD-dependent formaldehyde dehydrogenase. |
| NAD-linked formaldehyde dehydrogenase. |
| Reaction catalysed |
|---|
- NADP(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADPH + S-formylglutathione
- NAD(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADH + S-formylglutathione
|
| Comment(s) |
|---|
- The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from
glutathione and formaldehyde; its rate of formation is increased in
some bacteria by the presence of EC 4.4.1.22.
- Forms part of the pathway that detoxifies formaldehyde, since the
product is hydrolyzed by EC 3.1.2.12.
- Also specifically reduces S-nitrosylglutathione.
- Formerly EC 1.2.1.1.
|
| Cross-references |
|---|
| BRENDA | 1.1.1.284 |
| EC2PDB | 1.1.1.284 |
| ExplorEnz | 1.1.1.284 |
| PRIAM enzyme-specific profiles | 1.1.1.284 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.284 |
| IUBMB Enzyme Nomenclature | 1.1.1.284 |
| IntEnz | 1.1.1.284 |
| MEDLINE | Find literature relating to 1.1.1.284 |
| MetaCyc | 1.1.1.284 |
| Rhea expert-curated reactions | 1.1.1.284 |
| UniProtKB/Swiss-Prot |
| P81600, ADHH_GADMO; | P72324, ADHI_CERS4; | P81601, ADHL_GADMO; |
| Q96533, ADHX_ARATH; | Q3ZC42, ADHX_BOVIN; | Q17335, ADHX_CAEEL; |
| Q54TC2, ADHX_DICDI; | P46415, ADHX_DROME; | P19854, ADHX_HORSE; |
| P11766, ADHX_HUMAN; | P93629, ADHX_MAIZE; | P28474, ADHX_MOUSE; |
| P80360, ADHX_MYXGL; | P81431, ADHX_OCTVU; | A2XAZ3, ADHX_ORYSI; |
| Q0DWH1, ADHX_ORYSJ; | P80572, ADHX_PEA; | O19053, ADHX_RABIT; |
| P12711, ADHX_RAT; | P80467, ADHX_SAAHA; | P86884, ADHX_SCYCA; |
| P79896, ADHX_SPAAU; | P78870, FADH1_SCHPO; | O74540, FADH2_SCHPO; |
| P0CL53, FADH_ASPOR; | Q06099, FADH_CANMA; | P47734, FADH_METMR; |
| P45382, FADH_PARDE; | O74685, FADH_PICPA; | P32771, FADH_YEAST; |
| A7ZIA4, FRMA_ECO24; | Q8X5J4, FRMA_ECO57; | A7ZX04, FRMA_ECOHS; |
| A1A835, FRMA_ECOK1; | Q0TKS7, FRMA_ECOL5; | Q8FKG1, FRMA_ECOL6; |
| B1J085, FRMA_ECOLC; | P25437, FRMA_ECOLI; | B1LIP1, FRMA_ECOSM; |
| Q1RFI7, FRMA_ECOUT; | P44557, FRMA_HAEIN; | P39450, FRMA_PHODP; |
| Q3Z550, FRMA_SHISS; | P73138, FRMA_SYNY3; |
|