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ENZYME

ENZYME entry: EC 4.4.1.22

PURL: https://purl.expasy.org/enzyme/EC/4.4.1.22
Accepted Name
S-(hydroxymethyl)glutathione synthase
Alternative Name(s)
glutathione-dependent formaldehyde-activating enzyme
Reaction catalysed
S-(hydroxymethyl)glutathione = glutathione + formaldehyde
Comment(s)
  • The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, in the formaldehyde- detoxification pathway.
  • Formerly EC 1.2.1.1.
Cross-references
BRENDA4.4.1.22
EC2PDB4.4.1.22
ExplorEnz4.4.1.22
KEGG Ligand Database for Enzyme Nomenclature4.4.1.22
IUBMB Enzyme Nomenclature4.4.1.22
MEDLINEFind literature relating to 4.4.1.22
MetaCyc4.4.1.22
Rhea expert-curated reactions4.4.1.22
UniProtKB/Swiss-Prot
E1VBT6, GFAL_HALEDB8NDP1, GFA_ASPFNA2QBH6, GFA_ASPNC
P0CL54, GFA_ASPORQ0CMY6, GFA_ASPTNQ89GX9, GFA_BRADU
A5EP16, GFA_BRASBA4YZ37, GFA_BRASOE3QRY8, GFA_COLGM
C8VDQ3, GFA_EMENIC7Z147, GFA_FUSV7Q51669, GFA_PARDE
A1AXY8, GFA_PARDPB6HE56, GFA_PENRWQ0V314, GFA_PHANO
B2ACV0, GFA_PODANB2W9N9, GFA_PYRTRE3S405, GFA_PYRTT
Q98LU4, GFA_RHILOQ92WX6, GFA_RHIMEQ07HI5, GFA_RHOP5
Q21D57, GFA_RHOPBD1ZK87, GFA_SORMKB6QNA1, GFA_TALMQ
C9S7Z6, GFA_VERA1Q8PPF1, GFA_XANACQ4UYL9, GFA_XANC8
B0RNW7, GFA_XANCBQ8P5F3, GFA_XANCPQ3BXJ3, GFA_XANE5

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-