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ENZYME entry: EC 4.4.1.22

Accepted Name
S-(hydroxymethyl)glutathione synthase.
Alternative Name(s)
Glutathione-dependent formaldehyde-activating enzyme.
Reaction catalysed
S-(hydroxymethyl)glutathione <=> glutathione + formaldehyde
Comment(s)
  • The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, in the formaldehyde- detoxification pathway.
  • Formerly EC 1.2.1.1.
Cross-references
BRENDA4.4.1.22
EC2PDB4.4.1.22
ExplorEnz4.4.1.22
PRIAM enzyme-specific profiles4.4.1.22
KEGG Ligand Database for Enzyme Nomenclature4.4.1.22
IUBMB Enzyme Nomenclature4.4.1.22
IntEnz4.4.1.22
MEDLINEFind literature relating to 4.4.1.22
MetaCyc4.4.1.22
Rhea expert-curated reactions4.4.1.22
UniProtKB/Swiss-Prot
E1VBT6, GFAL_HALED;  B8NDP1, GFA_ASPFN;  A2QBH6, GFA_ASPNC;  
P0CL54, GFA_ASPOR;  Q0CMY6, GFA_ASPTN;  Q89GX9, GFA_BRADU;  
A5EP16, GFA_BRASB;  A4YZ37, GFA_BRASO;  E3QRY8, GFA_COLGM;  
C8VDQ3, GFA_EMENI;  C7Z147, GFA_FUSV7;  Q51669, GFA_PARDE;  
A1AXY8, GFA_PARDP;  B6HE56, GFA_PENRW;  Q0V314, GFA_PHANO;  
B2ACV0, GFA_PODAN;  B2W9N9, GFA_PYRTR;  E3S405, GFA_PYRTT;  
Q98LU4, GFA_RHILO;  Q92WX6, GFA_RHIME;  Q07HI5, GFA_RHOP5;  
Q21D57, GFA_RHOPB;  D1ZK87, GFA_SORMK;  B6QNA1, GFA_TALMQ;  
C9S7Z6, GFA_VERA1;  Q8PPF1, GFA_XANAC;  Q3BXJ3, GFA_XANC5;  
Q4UYL9, GFA_XANC8;  B0RNW7, GFA_XANCB;  Q8P5F3, GFA_XANCP;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
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